| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BVF INC/IL | 6,655,128 | 17,503,000 | 26.35% | ||
| 2 | NEA Management Company, LLC | 4,566,666 | 12,010,000 | 18.08% | ||
| 3 | RTW INVESTMENTS, LP | 2,665,643 | 7,011,000 | 10.56% | ||
| 4 | VANGUARD GROUP INC | 1,709,699 | 4,496,000 | 6.77% | ||
| 5 | Camber Capital Management LP | 1,560,000 | 4,103,000 | 6.18% | ||
| 6 | BlackRock Institutional Trust Company, N.A. | 1,143,118 | 3,006,000 | 4.53% | ||
| 7 | D. E. Shaw & Co., Inc. | 736,663 | 1,937,000 | 2.92% | ||
| 8 | Sarissa Capital Management LP | 630,000 | 1,657,000 | 2.49% | ||
| 9 | EcoR1 Capital, LLC | 619,699 | 1,630,000 | 2.45% | ||
| 10 | FRANKLIN RESOURCES INC | 613,234 | 1,613,000 | 2.43% | ||
| 11 | FMR LLC | 531,606 | 1,398,000 | 2.10% | ||
| 12 | DAFNA Capital Management LLC | 465,293 | 1,224,000 | 1.84% | ||
| 13 | DIMENSIONAL FUND ADVISORS LP | 461,706 | 1,214,000 | 1.83% | ||
| 14 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 412,500 | 1,085,000 | 1.63% | ||
| 15 | GEODE CAPITAL MANAGEMENT, LLC | 179,181 | 471,000 | 0.71% | ||
| 16 | MORGAN STANLEY | 173,034 | 455,000 | 0.69% | ||
| 17 | DEUTSCHE BANK AG\ | 172,559 | 452,000 | 0.68% | ||
| 18 | TWO SIGMA ADVISERS, LP | 169,421 | 446,000 | 0.67% | ||
| 19 | RENAISSANCE TECHNOLOGIES LLC | 161,732 | 425,000 | 0.64% | ||
| 20 | TWO SIGMA INVESTMENTS, LP | 137,256 | 361,000 | 0.54% | ||
| 21 | DRW Securities, LLC | 130,000 | 342,000 | 0.51% | ||
| 22 | Bank of New York Mellon Corp | 124,390 | 327,000 | 0.49% | ||
| 23 | Connor, Clark & Lunn Investment Management Ltd. | 104,380 | 275,000 | 0.41% | ||
| 24 | Arbor Investment Advisors, LLC | 104,260 | 274,000 | 0.41% | ||
| 25 | Spark Investment Management LLC | 101,800 | 266,000 | 0.40% | ||
| 26 | GOLDMAN SACHS GROUP INC | 100,972 | 266,000 | 0.40% | ||
| 27 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 94,000 | 239,000 | 0.36% | ||
| 28 | BlackRock Fund Advisors | 87,809 | 231,000 | 0.35% | ||
| 29 | NORTHERN TRUST CORP | 62,044 | 163,000 | 0.25% | ||
| 30 | Nine Chapters Capital Management LLC | 59,700 | 157,000 | 0.24% | ||
| 31 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 58,300 | 153,000 | 0.23% | Call | |
| 32 | Weiss Multi-Strategy Advisers LLC | 55,000 | 145,000 | 0.22% | ||
| 33 | Virtu KCG Holdings LLC | 40,677 | 107,000 | 0.16% | ||
| 34 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 39,171 | 103,000 | 0.16% | ||
| 35 | OAK ASSOCIATES LTD /OH/ | 38,456 | 101,000 | 0.15% | ||
| 36 | BANK OF AMERICA CORP /DE/ | 37,165 | 97,000 | 0.15% | ||
| 37 | TFS CAPITAL LLC | 32,989 | 87,000 | 0.13% | ||
| 38 | OXFORD ASSET MANAGEMENT LLP | 31,997 | 84,000 | 0.13% | ||
| 39 | A.R.T. Advisors, LLC | 31,863 | 83,000 | 0.12% | ||
| 40 | PANAGORA ASSET MANAGEMENT INC | 26,682 | 70,000 | 0.11% | ||
| 41 | STATE STREET CORP | 23,227 | 60,000 | 0.09% | ||
| 42 | UBS Group AG | 22,400 | 59,000 | 0.09% | Call | |
| 43 | MILLENNIUM MANAGEMENT LLC | 19,810 | 52,000 | 0.08% | ||
| 44 | CITADEL ADVISORS LLC | 16,890 | 44,000 | 0.07% | ||
| 45 | Rotella Capital Management, Inc. | 15,631 | 41,000 | 0.06% | ||
| 46 | PDT Partners, LLC | 10,151 | 27,000 | 0.04% | ||
| 47 | Nationwide Fund Advisors | 9,300 | 24,000 | 0.04% | ||
| 48 | BlackRock Investment Management, LLC | 5,648 | 15,000 | 0.02% | ||
| 49 | Invesco Ltd. | 3,236 | 9,000 | 0.01% | ||
| 50 | MUFG Americas Holdings Corp | 3,020 | 8,000 | 0.01% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
