| 1 |
BVF INC/IL |
6,655,128 |
18,568,000 |
25.51% |
|
|
| 2 |
NEA Management Company, LLC |
4,566,666 |
12,741,000 |
17.50% |
|
|
| 3 |
RTW INVESTMENTS, LP |
2,665,643 |
7,437,000 |
10.22% |
|
|
| 4 |
DG Capital Management, LLC |
1,603,612 |
4,474,000 |
6.15% |
|
|
| 5 |
Camber Capital Management LP |
1,560,000 |
4,352,000 |
5.98% |
|
|
| 6 |
VANGUARD GROUP INC |
1,307,539 |
3,648,000 |
5.01% |
|
|
| 7 |
BlackRock Institutional Trust Company, N.A. |
1,153,681 |
3,219,000 |
4.42% |
|
|
| 8 |
D. E. Shaw & Co., Inc. |
757,226 |
2,113,000 |
2.90% |
|
|
| 9 |
Sarissa Capital Management LP |
630,000 |
1,758,000 |
2.42% |
|
|
| 10 |
EcoR1 Capital, LLC |
619,699 |
1,729,000 |
2.38% |
|
|
| 11 |
FRANKLIN RESOURCES INC |
613,234 |
1,711,000 |
2.35% |
|
|
| 12 |
Avoro Capital Advisors LLC |
587,315 |
1,639,000 |
2.25% |
|
|
| 13 |
FMR LLC |
568,343 |
1,586,000 |
2.18% |
|
|
| 14 |
DIMENSIONAL FUND ADVISORS LP |
472,923 |
1,319,000 |
1.81% |
|
|
| 15 |
DAFNA Capital Management LLC |
463,914 |
1,294,000 |
1.78% |
|
SH |
| 16 |
RENAISSANCE TECHNOLOGIES LLC |
332,733 |
928,000 |
1.27% |
|
|
| 17 |
DEUTSCHE BANK AG\ |
214,715 |
598,000 |
0.82% |
|
|
| 18 |
GEODE CAPITAL MANAGEMENT, LLC |
179,465 |
500,000 |
0.69% |
|
|
| 19 |
MORGAN STANLEY |
163,720 |
457,000 |
0.63% |
|
|
| 20 |
Bank of New York Mellon Corp |
129,520 |
362,000 |
0.50% |
|
|
| 21 |
Connor, Clark & Lunn Investment Management Ltd. |
104,380 |
291,000 |
0.40% |
|
|
| 22 |
Arbor Investment Advisors, LLC |
103,260 |
288,000 |
0.40% |
|
|
| 23 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
94,000 |
262,000 |
0.36% |
|
|
| 24 |
GOLDMAN SACHS GROUP INC |
77,372 |
216,000 |
0.30% |
|
|
| 25 |
BlackRock Fund Advisors |
75,987 |
212,000 |
0.29% |
|
|
| 26 |
Spark Investment Management LLC |
65,900 |
181,000 |
0.25% |
|
|
| 27 |
Ancora Advisors LLC |
50,000 |
139,000 |
0.19% |
|
|
| 28 |
Weiss Multi-Strategy Advisers LLC |
46,500 |
130,000 |
0.18% |
|
|
| 29 |
NORTHERN TRUST CORP |
45,935 |
128,000 |
0.18% |
|
|
| 30 |
BANK OF AMERICA CORP /DE/ |
39,501 |
110,000 |
0.15% |
|
|
| 31 |
OAK ASSOCIATES LTD /OH/ |
38,456 |
107,000 |
0.15% |
|
|
| 32 |
PANAGORA ASSET MANAGEMENT INC |
20,336 |
56,000 |
0.08% |
|
|
| 33 |
STATE STREET CORP |
18,027 |
51,000 |
0.07% |
|
|
| 34 |
OXFORD ASSET MANAGEMENT LLP |
13,213 |
37,000 |
0.05% |
|
|
| 35 |
PDT Partners, LLC |
10,151 |
28,000 |
0.04% |
|
|
| 36 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
10,100 |
28,000 |
0.04% |
Call |
|
| 37 |
APIS CAPITAL ADVISORS, LLC |
10,000 |
28,000 |
0.04% |
|
|
| 38 |
Nationwide Fund Advisors |
9,300 |
26,000 |
0.04% |
|
|
| 39 |
BlackRock Investment Management, LLC |
4,561 |
13,000 |
0.02% |
|
|
| 40 |
MUFG Americas Holdings Corp |
3,770 |
11,000 |
0.02% |
|
|
| 41 |
Walleye Trading LLC |
2,300 |
6,000 |
0.01% |
|
|
| 42 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
722 |
2,000 |
0.00% |
|
|
| 43 |
LADENBURG THALMANN FINANCIAL SERVICES INC. |
500 |
1,000 |
0.00% |
|
|
| 44 |
Jolley Asset Management, LLC |
500 |
1,000 |
0.00% |
|
|
| 45 |
GLENMEDE TRUST CO NA |
627 |
1,000 |
0.00% |
|
|
| 46 |
Shamrock Asset Management LLC |
400 |
1,000 |
0.00% |
|
|
| 47 |
ROYAL BANK OF CANADA |
197 |
1,000 |
0.00% |
|
|
| 48 |
SIMPLEX TRADING, LLC |
500 |
1,000 |
0.00% |
|
|
| 49 |
WELLS FARGO & COMPANY/MN |
1 |
0 |
0.00% |
|
|
