| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BVF INC/IL | 6,655,128 | 16,837,000 | 33.44% | ||
| 2 | NEA Management Company, LLC | 4,566,666 | 11,554,000 | 22.95% | ||
| 3 | BlackRock Institutional Trust Company, N.A. | 1,131,409 | 2,862,000 | 5.68% | ||
| 4 | VANGUARD GROUP INC | 1,072,918 | 2,715,000 | 5.39% | ||
| 5 | D. E. Shaw & Co., Inc. | 669,858 | 1,695,000 | 3.37% | ||
| 6 | Sarissa Capital Management LP | 630,000 | 1,594,000 | 3.17% | ||
| 7 | FRANKLIN RESOURCES INC | 613,234 | 1,551,000 | 3.08% | ||
| 8 | JENNISON ASSOCIATES LLC | 554,491 | 1,403,000 | 2.79% | ||
| 9 | DIMENSIONAL FUND ADVISORS LP | 529,766 | 1,340,000 | 2.66% | ||
| 10 | FMR LLC | 519,559 | 1,314,000 | 2.61% | ||
| 11 | TFS CAPITAL LLC | 363,189 | 919,000 | 1.83% | ||
| 12 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 251,300 | 636,000 | 1.26% | ||
| 13 | MORGAN STANLEY | 195,815 | 496,000 | 0.99% | ||
| 14 | GEODE CAPITAL MANAGEMENT, LLC | 178,968 | 452,000 | 0.90% | ||
| 15 | GOLDMAN SACHS GROUP INC | 142,408 | 360,000 | 0.71% | ||
| 16 | DEUTSCHE BANK AG\ | 141,306 | 357,000 | 0.71% | ||
| 17 | TWO SIGMA ADVISERS, LP | 138,521 | 350,000 | 0.70% | ||
| 18 | DAFNA Capital Management LLC | 133,972 | 339,000 | 0.67% | SH | |
| 19 | Bank of New York Mellon Corp | 124,248 | 314,000 | 0.62% | ||
| 20 | Arbor Investment Advisors, LLC | 104,260 | 264,000 | 0.52% | ||
| 21 | Connor, Clark & Lunn Investment Management Ltd. | 94,714 | 240,000 | 0.48% | ||
| 22 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 94,000 | 238,000 | 0.47% | ||
| 23 | TWO SIGMA INVESTMENTS, LP | 87,600 | 222,000 | 0.44% | ||
| 24 | BlackRock Fund Advisors | 81,545 | 206,000 | 0.41% | ||
| 25 | Ancora Advisors LLC | 75,551 | 191,000 | 0.38% | ||
| 26 | Spark Investment Management LLC | 75,900 | 189,000 | 0.38% | ||
| 27 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 68,231 | 173,000 | 0.34% | ||
| 28 | NORTHERN TRUST CORP | 60,776 | 153,000 | 0.30% | ||
| 29 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 55,800 | 141,000 | 0.28% | Call | |
| 30 | Weiss Multi-Strategy Advisers LLC | 55,000 | 139,000 | 0.28% | ||
| 31 | GROUP ONE TRADING LLC | 45,344 | 115,000 | 0.23% | ||
| 32 | Nine Chapters Capital Management LLC | 41,000 | 104,000 | 0.21% | ||
| 33 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 40,354 | 102,000 | 0.20% | ||
| 34 | OAK ASSOCIATES LTD /OH/ | 38,456 | 97,000 | 0.19% | ||
| 35 | BANK OF AMERICA CORP /DE/ | 37,125 | 94,000 | 0.19% | ||
| 36 | RENAISSANCE TECHNOLOGIES LLC | 34,979 | 88,000 | 0.17% | ||
| 37 | UBS AG | 28,800 | 73,000 | 0.14% | Call | |
| 38 | PANAGORA ASSET MANAGEMENT INC | 26,682 | 67,000 | 0.13% | ||
| 39 | STATE STREET CORP | 24,927 | 63,000 | 0.13% | ||
| 40 | A.R.T. Advisors, LLC | 24,088 | 60,000 | 0.12% | ||
| 41 | MILLENNIUM MANAGEMENT LLC | 17,498 | 44,000 | 0.09% | ||
| 42 | PDT Partners, LLC | 15,751 | 40,000 | 0.08% | ||
| 43 | JPMORGAN CHASE & CO | 15,525 | 39,000 | 0.08% | ||
| 44 | JANE STREET GROUP, LLC | 11,450 | 29,000 | 0.06% | ||
| 45 | Nationwide Fund Advisors | 9,300 | 24,000 | 0.05% | ||
| 46 | CITADEL ADVISORS LLC | 8,089 | 20,000 | 0.04% | ||
| 47 | BlackRock Investment Management, LLC | 5,648 | 14,000 | 0.03% | ||
| 48 | BNP PARIBAS FINANCIAL MARKETS | 3,264 | 8,258 | 0.02% | ||
| 49 | Invesco Ltd. | 3,236 | 8,000 | 0.02% | ||
| 50 | UBS AG | 1,861 | 5,000 | 0.01% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
