| 1 |
BVF INC/IL |
6,655,128 |
19,766,000 |
26.30% |
|
|
| 2 |
NEA Management Company, LLC |
4,566,666 |
13,563,000 |
18.04% |
|
|
| 3 |
RTW INVESTMENTS, LP |
2,665,643 |
7,917,000 |
10.53% |
|
|
| 4 |
VANGUARD GROUP INC |
1,794,032 |
5,329,000 |
7.09% |
|
|
| 5 |
Camber Capital Management LP |
1,560,000 |
4,633,000 |
6.16% |
|
|
| 6 |
BlackRock Institutional Trust Company, N.A. |
1,143,893 |
3,397,000 |
4.52% |
|
|
| 7 |
D. E. Shaw & Co., Inc. |
736,252 |
2,186,000 |
2.91% |
|
|
| 8 |
Sarissa Capital Management LP |
630,000 |
1,871,000 |
2.49% |
|
|
| 9 |
EcoR1 Capital, LLC |
619,699 |
1,841,000 |
2.45% |
|
|
| 10 |
FRANKLIN RESOURCES INC |
613,234 |
1,821,000 |
2.42% |
|
|
| 11 |
FMR LLC |
518,606 |
1,540,000 |
2.05% |
|
|
| 12 |
Avoro Capital Advisors LLC |
466,297 |
1,385,000 |
1.84% |
|
|
| 13 |
DAFNA Capital Management LLC |
465,293 |
1,382,000 |
1.84% |
|
SH |
| 14 |
DIMENSIONAL FUND ADVISORS LP |
449,924 |
1,336,000 |
1.78% |
|
|
| 15 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
412,500 |
1,225,000 |
1.63% |
|
|
| 16 |
DEUTSCHE BANK AG\ |
292,598 |
868,000 |
1.15% |
|
|
| 17 |
RENAISSANCE TECHNOLOGIES LLC |
256,322 |
761,000 |
1.01% |
|
|
| 18 |
MORGAN STANLEY |
182,400 |
542,000 |
0.72% |
|
|
| 19 |
GEODE CAPITAL MANAGEMENT, LLC |
179,394 |
532,000 |
0.71% |
|
|
| 20 |
Bank of New York Mellon Corp |
124,249 |
369,000 |
0.49% |
|
|
| 21 |
Connor, Clark & Lunn Investment Management Ltd. |
104,380 |
310,000 |
0.41% |
|
|
| 22 |
Arbor Investment Advisors, LLC |
103,660 |
308,000 |
0.41% |
|
|
| 23 |
BlackRock Fund Advisors |
82,241 |
244,000 |
0.32% |
|
|
| 24 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
94,000 |
239,000 |
0.32% |
|
|
| 25 |
GOLDMAN SACHS GROUP INC |
79,471 |
236,000 |
0.31% |
|
|
| 26 |
Spark Investment Management LLC |
69,600 |
204,000 |
0.27% |
|
|
| 27 |
NORTHERN TRUST CORP |
59,535 |
177,000 |
0.24% |
|
|
| 28 |
Ancora Advisors LLC |
0 |
148,000 |
0.20% |
|
|
| 29 |
Weiss Multi-Strategy Advisers LLC |
46,400 |
138,000 |
0.18% |
|
|
| 30 |
PARAMETRIC PORTFOLIO ASSOCIATES LLC |
39,171 |
116,000 |
0.15% |
|
|
| 31 |
OAK ASSOCIATES LTD /OH/ |
38,456 |
114,000 |
0.15% |
|
|
| 32 |
BANK OF AMERICA CORP /DE/ |
37,125 |
110,000 |
0.15% |
|
|
| 33 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
33,600 |
100,000 |
0.13% |
Call |
|
| 34 |
OXFORD ASSET MANAGEMENT LLP |
29,201 |
87,000 |
0.12% |
|
|
| 35 |
STATE STREET CORP |
23,227 |
69,000 |
0.09% |
|
|
| 36 |
PANAGORA ASSET MANAGEMENT INC |
20,336 |
60,000 |
0.08% |
|
|
| 37 |
Nine Chapters Capital Management LLC |
18,600 |
55,000 |
0.07% |
|
|
| 38 |
THOMPSON DAVIS & CO., INC. |
14,000 |
42,000 |
0.06% |
|
|
| 39 |
CITADEL ADVISORS LLC |
13,752 |
41,000 |
0.05% |
|
|
| 40 |
PDT Partners, LLC |
10,151 |
30,000 |
0.04% |
|
|
| 41 |
Nationwide Fund Advisors |
9,300 |
28,000 |
0.04% |
|
|
| 42 |
BlackRock Investment Management, LLC |
5,648 |
17,000 |
0.02% |
|
|
| 43 |
MUFG Americas Holdings Corp |
3,770 |
11,000 |
0.01% |
|
|
| 44 |
Invesco Ltd. |
3,236 |
10,000 |
0.01% |
|
|
| 45 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
722 |
2,000 |
0.00% |
|
|
| 46 |
AMERICAN INTERNATIONAL GROUP, INC. |
500 |
1,485 |
0.00% |
|
|
| 47 |
Creative Planning |
250 |
1,000 |
0.00% |
|
|
| 48 |
Jolley Asset Management, LLC |
500 |
1,000 |
0.00% |
|
|
| 49 |
GLENMEDE TRUST CO NA |
627 |
1,000 |
0.00% |
|
|
| 50 |
LADENBURG THALMANN FINANCIAL SERVICES INC. |
500 |
1,000 |
0.00% |
|
|
