| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BVF INC/IL | 6,655,128 | 30,015,000 | 28.95% | ||
| 2 | NEA Management Company, LLC | 4,566,666 | 20,596,000 | 19.87% | ||
| 3 | FRANKLIN RESOURCES INC | 2,713,347 | 12,237,000 | 11.80% | ||
| 4 | BlackRock Institutional Trust Company, N.A. | 1,023,278 | 4,615,000 | 4.45% | ||
| 5 | VANGUARD GROUP INC | 973,041 | 4,389,000 | 4.23% | ||
| 6 | TFS CAPITAL LLC | 740,745 | 3,341,000 | 3.22% | ||
| 7 | Sarissa Capital Management LP | 630,000 | 2,841,000 | 2.74% | ||
| 8 | JENNISON ASSOCIATES LLC | 603,322 | 2,721,000 | 2.62% | ||
| 9 | DIMENSIONAL FUND ADVISORS LP | 554,560 | 2,501,000 | 2.41% | ||
| 10 | D. E. Shaw & Co., Inc. | 540,002 | 2,435,000 | 2.35% | ||
| 11 | PACIFIC ALTERNATIVE ASSET MANAGEMENT COMPANY, LLC | 497,700 | 2,245,000 | 2.17% | Call | |
| 12 | FMR LLC | 390,249 | 1,760,000 | 1.70% | ||
| 13 | NORTHERN TRUST CORP | 292,051 | 1,317,000 | 1.27% | ||
| 14 | DEUTSCHE BANK AG\ | 187,393 | 843,000 | 0.81% | ||
| 15 | MORGAN STANLEY | 185,905 | 840,000 | 0.81% | ||
| 16 | GEODE CAPITAL MANAGEMENT, LLC | 173,669 | 783,000 | 0.76% | ||
| 17 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 143,300 | 646,000 | 0.62% | ||
| 18 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 130,200 | 587,000 | 0.57% | Put | |
| 19 | TWO SIGMA ADVISERS, LP | 128,821 | 581,000 | 0.56% | ||
| 20 | Bank of New York Mellon Corp | 124,248 | 560,000 | 0.54% | ||
| 21 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 123,400 | 557,000 | 0.54% | Call | |
| 22 | Paloma Partners Management Co | 119,948 | 541,000 | 0.52% | ||
| 23 | GOLDMAN SACHS GROUP INC | 117,870 | 532,000 | 0.51% | ||
| 24 | Arbor Investment Advisors, LLC | 104,260 | 470,000 | 0.45% | ||
| 25 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 94,000 | 424,000 | 0.41% | ||
| 26 | BANK OF AMERICA CORP /DE/ | 93,520 | 422,000 | 0.41% | ||
| 27 | BlackRock Fund Advisors | 87,461 | 394,000 | 0.38% | ||
| 28 | TWO SIGMA INVESTMENTS, LP | 82,261 | 371,000 | 0.36% | ||
| 29 | COMMONWEALTH OF PENNSYLVANIA PUBLIC SCHOOL EMPLS RETRMT SYS | 79,458 | 358,000 | 0.35% | ||
| 30 | MILLENNIUM MANAGEMENT LLC | 69,047 | 311,000 | 0.30% | ||
| 31 | LMR Partners LLP | 60,417 | 272,000 | 0.26% | ||
| 32 | BARCLAYS PLC | 64,617 | 258,000 | 0.25% | ||
| 33 | GROUP ONE TRADING LLC | 54,704 | 247,000 | 0.24% | ||
| 34 | Weiss Multi-Strategy Advisers LLC | 50,000 | 226,000 | 0.22% | ||
| 35 | CREDIT SUISSE AG/ | 43,189 | 195,000 | 0.19% | ||
| 36 | PANAGORA ASSET MANAGEMENT INC | 39,310 | 177,000 | 0.17% | ||
| 37 | OAK ASSOCIATES LTD /OH/ | 38,456 | 173,000 | 0.17% | ||
| 38 | A.R.T. Advisors, LLC | 37,217 | 167,000 | 0.16% | ||
| 39 | Invesco Ltd. | 35,601 | 161,000 | 0.16% | ||
| 40 | RENAISSANCE TECHNOLOGIES LLC | 29,626 | 134,000 | 0.13% | ||
| 41 | Parkwood LLC | 26,980 | 122,000 | 0.12% | ||
| 42 | Nine Chapters Capital Management LLC | 26,900 | 121,000 | 0.12% | ||
| 43 | VIRGINIA RETIREMENT SYSTEMS ET Al | 25,700 | 116,000 | 0.11% | ||
| 44 | STATE STREET CORP | 24,927 | 114,000 | 0.11% | ||
| 45 | Connor, Clark & Lunn Investment Management Ltd. | 22,600 | 109,000 | 0.11% | ||
| 46 | PACIFIC ALTERNATIVE ASSET MANAGEMENT COMPANY, LLC | 21,850 | 99,000 | 0.10% | ||
| 47 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 21,088 | 95,000 | 0.09% | ||
| 48 | Alpine Global Management, LLC | 20,544 | 93,000 | 0.09% | ||
| 49 | UBS AG | 20,000 | 90,000 | 0.09% | Call | |
| 50 | PRELUDE CAPITAL MANAGEMENT, LLC | 16,700 | 75,000 | 0.07% | Call |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
