| 1 |
Artal Group S.A. |
57,517,978 |
463,019,000 |
59.41% |
|
|
| 2 |
FMR LLC |
14,915,092 |
120,066,000 |
15.41% |
|
|
| 3 |
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
6,473,674 |
52,113,000 |
6.69% |
|
|
| 4 |
Ulys, L.L.C. |
4,321,214 |
34,786,000 |
4.46% |
|
|
| 5 |
VANGUARD GROUP INC |
2,855,629 |
22,988,000 |
2.95% |
|
|
| 6 |
BlackRock Fund Advisors |
2,293,519 |
18,463,000 |
2.37% |
|
|
| 7 |
BlackRock Institutional Trust Company, N.A. |
1,190,631 |
9,585,000 |
1.23% |
|
|
| 8 |
MASTERS CAPITAL MANAGEMENT LLC |
1,129,708 |
9,094,000 |
1.17% |
|
|
| 9 |
TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY |
738,357 |
5,944,000 |
0.76% |
|
|
| 10 |
STATE STREET CORP |
559,383 |
4,504,000 |
0.58% |
|
|
| 11 |
NORTHERN TRUST CORP |
399,258 |
3,214,000 |
0.41% |
|
|
| 12 |
ROYCE & ASSOCIATES LP |
377,074 |
3,035,000 |
0.39% |
|
|
| 13 |
SABBY MANAGEMENT, LLC |
318,775 |
2,566,000 |
0.33% |
|
|
| 14 |
GEODE CAPITAL MANAGEMENT, LLC |
300,150 |
2,416,000 |
0.31% |
|
|
| 15 |
BRIDGER MANAGEMENT, LLC |
259,458 |
2,089,000 |
0.27% |
|
|
| 16 |
Bank of New York Mellon Corp |
229,847 |
1,850,000 |
0.24% |
|
|
| 17 |
Rhenman & Partners Asset Management AB |
170,915 |
1,376,000 |
0.18% |
|
|
| 18 |
RENAISSANCE TECHNOLOGIES LLC |
170,153 |
1,370,000 |
0.18% |
|
|
| 19 |
NORGES BANK |
158,669 |
1,277,000 |
0.16% |
|
|
| 20 |
BlackRock Investment Management, LLC |
144,410 |
1,163,000 |
0.15% |
|
|
| 21 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
141,792 |
1,141,000 |
0.15% |
|
|
| 22 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
131,450 |
1,059,000 |
0.14% |
|
|
| 23 |
CREDIT SUISSE AG/ |
122,080 |
983,000 |
0.13% |
|
|
| 24 |
OXFORD ASSET MANAGEMENT LLP |
104,625 |
842,000 |
0.11% |
|
|
| 25 |
ProShare Advisors LLC |
88,031 |
709,000 |
0.09% |
|
|
| 26 |
MILLENNIUM MANAGEMENT LLC |
84,240 |
678,000 |
0.09% |
|
|
| 27 |
ALLIANCEBERNSTEIN L.P. |
80,989 |
652,000 |
0.08% |
|
|
| 28 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
75,875 |
611,000 |
0.08% |
|
|
| 29 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
66,757 |
537,000 |
0.07% |
|
|
| 30 |
BLACKROCK ADVISORS LLC |
65,974 |
531,000 |
0.07% |
|
|
| 31 |
STIFEL FINANCIAL CORP |
62,296 |
501,000 |
0.06% |
|
|
| 32 |
TEACHERS ADVISORS, LLC |
60,041 |
483,000 |
0.06% |
|
|
| 33 |
RUSSELL FRANK CO/ |
58,505 |
471,000 |
0.06% |
|
|
| 34 |
Swiss National Bank |
58,014 |
467,000 |
0.06% |
|
|
| 35 |
NEW YORK STATE COMMON RETIREMENT FUND |
52,446 |
422,000 |
0.05% |
|
|
| 36 |
HOWARD HUGHES MEDICAL INSTITUTE |
51,520 |
415,000 |
0.05% |
|
|
| 37 |
DekaBank Deutsche Girozentrale |
50,841 |
409,000 |
0.05% |
|
|
| 38 |
RHUMBLINE ADVISERS |
46,807 |
377,000 |
0.05% |
|
|
| 39 |
WILLIAM HARRIS INVESTORS INC |
39,495 |
318,000 |
0.04% |
|
|
| 40 |
AQR CAPITAL MANAGEMENT LLC |
37,868 |
305,000 |
0.04% |
|
|
| 41 |
MORGAN STANLEY |
37,480 |
302,000 |
0.04% |
|
|
| 42 |
FALCON POINT CAPITAL, LLC |
37,039 |
298,000 |
0.04% |
|
|
| 43 |
MANAGED ACCOUNT ADVISORS LLC |
36,837 |
297,000 |
0.04% |
|
|
| 44 |
UNIVERSITY OF TEXAS/TEXAS AM INVESTMENT MANAGEMENT CO |
35,714 |
287,000 |
0.04% |
|
|
| 45 |
CITADEL ADVISORS LLC |
35,213 |
283,000 |
0.04% |
|
|
| 46 |
STEVENS CAPITAL MANAGEMENT LP |
34,048 |
274,000 |
0.04% |
|
|
| 47 |
DIMENSIONAL FUND ADVISORS LP |
33,602 |
270,000 |
0.03% |
|
|
| 48 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
30,641 |
247,000 |
0.03% |
|
|
| 49 |
TFS CAPITAL LLC |
29,307 |
236,000 |
0.03% |
|
|
| 50 |
JACOBS LEVY EQUITY MANAGEMENT, INC |
28,054 |
226,000 |
0.03% |
|
|
