| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Artal Group S.A. | 57,517,977 | 795,474,000 | 51.75% | ||
| 2 | FMR LLC | 15,605,451 | 215,823,000 | 14.04% | ||
| 3 | Ulys, L.L.C. | 4,321,214 | 59,762,000 | 3.89% | ||
| 4 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 4,120,509 | 56,987,000 | 3.71% | ||
| 5 | VANGUARD GROUP INC | 3,583,079 | 49,554,000 | 3.22% | ||
| 6 | BlackRock Fund Advisors | 2,977,143 | 41,174,000 | 2.68% | ||
| 7 | EAGLE ASSET MANAGEMENT INC | 2,866,616 | 39,645,000 | 2.58% | ||
| 8 | NEA Management Company, LLC | 2,382,286 | 32,947,000 | 2.14% | ||
| 9 | STATE STREET CORP | 1,591,365 | 22,008,000 | 1.43% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 1,434,807 | 19,843,000 | 1.29% | ||
| 11 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 1,217,575 | 16,839,000 | 1.10% | ||
| 12 | NORGES BANK | 909,764 | 12,582,000 | 0.82% | ||
| 13 | LOOMIS SAYLES & CO L P | 838,372 | 11,595,000 | 0.75% | ||
| 14 | COLUMBUS CIRCLE INVESTORS | 752,179 | 10,403,000 | 0.68% | ||
| 15 | BALYASNY ASSET MANAGEMENT L.P. | 718,505 | 9,937,000 | 0.65% | ||
| 16 | NORTHERN TRUST CORP | 584,968 | 8,090,000 | 0.53% | ||
| 17 | TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 558,729 | 7,727,000 | 0.50% | ||
| 18 | VOYA INVESTMENT MANAGEMENT LLC | 518,738 | 7,175,000 | 0.47% | ||
| 19 | Invesco Ltd. | 508,590 | 7,034,000 | 0.46% | ||
| 20 | GEODE CAPITAL MANAGEMENT, LLC | 429,279 | 5,936,000 | 0.39% | ||
| 21 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 313,911 | 4,342,000 | 0.28% | ||
| 22 | Jupiter Investment Management Ltd | 304,729 | 4,214,000 | 0.27% | ||
| 23 | JPMORGAN CHASE & CO | 304,210 | 4,207,000 | 0.27% | ||
| 24 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 300,000 | 4,149,000 | 0.27% | Call | |
| 25 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 267,946 | 3,706,000 | 0.24% | ||
| 26 | Bank of New York Mellon Corp | 261,077 | 3,611,000 | 0.23% | ||
| 27 | WELLINGTON MANAGEMENT GROUP LLP | 251,910 | 3,484,000 | 0.23% | ||
| 28 | BANK OF AMERICA CORP /DE/ | 251,876 | 3,483,000 | 0.23% | ||
| 29 | MILLENNIUM MANAGEMENT LLC | 226,852 | 3,137,000 | 0.20% | ||
| 30 | TIAA CREF INVESTMENT MANAGEMENT LLC | 224,648 | 3,107,000 | 0.20% | ||
| 31 | Candriam S.C.A. | 195,000 | 2,697,000 | 0.18% | ||
| 32 | ALLIANCEBERNSTEIN L.P. | 190,572 | 2,636,000 | 0.17% | ||
| 33 | GOLDMAN SACHS GROUP INC | 169,908 | 2,350,000 | 0.15% | ||
| 34 | BlackRock Investment Management, LLC | 155,257 | 2,147,000 | 0.14% | ||
| 35 | CITIGROUP INC | 151,100 | 2,090,000 | 0.14% | ||
| 36 | GSA CAPITAL PARTNERS LLP | 145,336 | 2,010,000 | 0.13% | ||
| 37 | MORGAN STANLEY | 142,489 | 1,971,000 | 0.13% | ||
| 38 | BLACKROCK ADVISORS LLC | 134,794 | 1,864,000 | 0.12% | ||
| 39 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 124,856 | 1,727,000 | 0.11% | ||
| 40 | FIRST TRUST ADVISORS LP | 120,857 | 1,671,000 | 0.11% | ||
| 41 | UBS Group AG | 119,687 | 1,655,000 | 0.11% | ||
| 42 | BANK OF MONTREAL /CAN/ | 107,610 | 1,639,000 | 0.11% | ||
| 43 | WELLS FARGO & COMPANY/MN | 110,584 | 1,529,000 | 0.10% | ||
| 44 | TEACHERS ADVISORS, LLC | 106,890 | 1,478,000 | 0.10% | ||
| 45 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 99,100 | 1,371,000 | 0.09% | Put | |
| 46 | AQR CAPITAL MANAGEMENT LLC | 95,025 | 1,314,000 | 0.09% | ||
| 47 | RUSSELL INVESTMENTS GROUP, LTD. | 89,797 | 1,242,000 | 0.08% | ||
| 48 | D. E. Shaw & Co., Inc. | 87,952 | 1,216,000 | 0.08% | ||
| 49 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 87,127 | 1,205,000 | 0.08% | ||
| 50 | AHL Partners LLP | 85,489 | 1,182,000 | 0.08% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
