| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Artal Group S.A. | 57,517,977 | 1,039,349,000 | 51.79% | ||
| 2 | FMR LLC | 15,579,856 | 281,528,000 | 14.03% | ||
| 3 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 4,790,981 | 86,573,000 | 4.31% | ||
| 4 | Ulys, L.L.C. | 4,321,214 | 78,084,000 | 3.89% | ||
| 5 | VANGUARD GROUP INC | 3,413,649 | 61,685,000 | 3.07% | ||
| 6 | BlackRock Fund Advisors | 2,468,459 | 44,605,000 | 2.22% | ||
| 7 | NEA Management Company, LLC | 2,382,286 | 43,048,000 | 2.15% | ||
| 8 | EAGLE ASSET MANAGEMENT INC | 1,727,954 | 31,224,000 | 1.56% | ||
| 9 | STATE STREET CORP | 1,357,994 | 24,539,000 | 1.22% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 1,275,461 | 23,048,000 | 1.15% | ||
| 11 | COLUMBUS CIRCLE INVESTORS | 1,046,088 | 18,903,000 | 0.94% | ||
| 12 | LOOMIS SAYLES & CO L P | 881,449 | 15,928,000 | 0.79% | ||
| 13 | NORGES BANK | 856,915 | 14,789,000 | 0.74% | ||
| 14 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 809,666 | 14,631,000 | 0.73% | ||
| 15 | TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 738,709 | 13,348,000 | 0.67% | ||
| 16 | D. E. Shaw & Co., Inc. | 667,130 | 12,055,000 | 0.60% | ||
| 17 | Invesco Ltd. | 614,606 | 11,106,000 | 0.55% | ||
| 18 | NORTHERN TRUST CORP | 565,318 | 10,214,000 | 0.51% | ||
| 19 | BALYASNY ASSET MANAGEMENT L.P. | 551,900 | 9,973,000 | 0.50% | ||
| 20 | VOYA INVESTMENT MANAGEMENT LLC | 518,352 | 9,367,000 | 0.47% | ||
| 21 | MILLENNIUM MANAGEMENT LLC | 459,950 | 8,311,000 | 0.41% | ||
| 22 | GEODE CAPITAL MANAGEMENT, LLC | 408,797 | 7,386,000 | 0.37% | ||
| 23 | BRIDGER MANAGEMENT, LLC | 336,966 | 6,089,000 | 0.30% | ||
| 24 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 315,145 | 5,695,000 | 0.28% | ||
| 25 | TIAA CREF INVESTMENT MANAGEMENT LLC | 294,598 | 5,323,000 | 0.27% | ||
| 26 | JPMORGAN CHASE & CO | 290,850 | 5,256,000 | 0.26% | ||
| 27 | TWO SIGMA INVESTMENTS, LP | 283,651 | 5,126,000 | 0.26% | ||
| 28 | OXFORD ASSET MANAGEMENT LLP | 277,954 | 5,023,000 | 0.25% | ||
| 29 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 258,353 | 4,668,000 | 0.23% | ||
| 30 | WELLINGTON MANAGEMENT GROUP LLP | 251,806 | 4,550,000 | 0.23% | ||
| 31 | Bank of New York Mellon Corp | 240,922 | 4,353,000 | 0.22% | ||
| 32 | Jupiter Investment Management Ltd | 215,005 | 3,885,000 | 0.19% | ||
| 33 | WELLS FARGO & COMPANY/MN | 214,057 | 3,868,000 | 0.19% | ||
| 34 | ALLIANCEBERNSTEIN L.P. | 205,542 | 3,714,000 | 0.19% | ||
| 35 | BANK OF AMERICA CORP /DE/ | 196,172 | 3,546,000 | 0.18% | ||
| 36 | Candriam S.C.A. | 195,000 | 3,524,000 | 0.18% | ||
| 37 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 193,300 | 3,493,000 | 0.17% | Put | |
| 38 | DRIEHAUS CAPITAL MANAGEMENT LLC | 184,291 | 3,330,000 | 0.17% | ||
| 39 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 179,100 | 3,236,000 | 0.16% | Call | |
| 40 | TWO SIGMA ADVISERS, LP | 159,503 | 2,882,000 | 0.14% | ||
| 41 | BlackRock Investment Management, LLC | 155,297 | 2,806,000 | 0.14% | ||
| 42 | FIRST TRUST ADVISORS LP | 125,232 | 2,263,000 | 0.11% | ||
| 43 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 124,856 | 2,256,000 | 0.11% | ||
| 44 | GOLDMAN SACHS GROUP INC | 123,327 | 2,229,000 | 0.11% | ||
| 45 | BLACKROCK ADVISORS LLC | 121,822 | 2,201,000 | 0.11% | ||
| 46 | MORGAN STANLEY | 120,780 | 2,183,000 | 0.11% | ||
| 47 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 115,746 | 2,092,000 | 0.10% | ||
| 48 | AQR CAPITAL MANAGEMENT LLC | 114,159 | 2,063,000 | 0.10% | ||
| 49 | CITIGROUP INC | 100,200 | 1,811,000 | 0.09% | Call | |
| 50 | Laurion Capital Management LP | 100,000 | 1,807,000 | 0.09% | Call |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
