| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Artal Group S.A. | 57,517,977 | 687,340,000 | 51.65% | ||
| 2 | FMR LLC | 15,565,448 | 186,007,000 | 13.98% | ||
| 3 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 7,221,718 | 86,299,000 | 6.48% | ||
| 4 | Ulys, L.L.C. | 4,321,214 | 51,639,000 | 3.88% | ||
| 5 | VANGUARD GROUP INC | 3,063,884 | 36,613,000 | 2.75% | ||
| 6 | NEA Management Company, LLC | 2,382,286 | 28,468,000 | 2.14% | ||
| 7 | BlackRock Fund Advisors | 2,322,113 | 27,749,000 | 2.09% | ||
| 8 | EAGLE ASSET MANAGEMENT INC | 1,481,973 | 17,709,000 | 1.33% | ||
| 9 | STATE STREET CORP | 1,209,379 | 14,450,000 | 1.09% | ||
| 10 | LOOMIS SAYLES & CO L P | 1,107,395 | 13,233,000 | 0.99% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 1,107,208 | 13,231,000 | 0.99% | ||
| 12 | MILLENNIUM MANAGEMENT LLC | 1,079,140 | 12,896,000 | 0.97% | ||
| 13 | BRIDGER MANAGEMENT, LLC | 1,029,926 | 12,308,000 | 0.92% | ||
| 14 | TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 933,157 | 11,151,000 | 0.84% | ||
| 15 | Invesco Ltd. | 770,370 | 9,206,000 | 0.69% | ||
| 16 | VOYA INVESTMENT MANAGEMENT LLC | 751,335 | 8,979,000 | 0.67% | ||
| 17 | HANCOCK WHITNEY CORP | 661,745 | 7,908,000 | 0.59% | ||
| 18 | COLUMBUS CIRCLE INVESTORS | 594,342 | 7,102,000 | 0.53% | ||
| 19 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 524,380 | 6,266,000 | 0.47% | ||
| 20 | NORTHERN TRUST CORP | 483,946 | 5,783,000 | 0.43% | ||
| 21 | NORGES BANK | 409,324 | 4,891,000 | 0.37% | ||
| 22 | GEODE CAPITAL MANAGEMENT, LLC | 353,192 | 4,220,000 | 0.32% | ||
| 23 | ROYCE & ASSOCIATES LP | 340,589 | 4,070,000 | 0.31% | ||
| 24 | OXFORD ASSET MANAGEMENT LLP | 326,760 | 3,905,000 | 0.29% | ||
| 25 | FALCON POINT CAPITAL, LLC | 277,993 | 3,322,000 | 0.25% | ||
| 26 | GOLDMAN SACHS GROUP INC | 250,000 | 2,988,000 | 0.22% | Call | |
| 27 | GOLDMAN SACHS GROUP INC | 250,000 | 2,988,000 | 0.22% | Put | |
| 28 | Tekla Capital Management LLC | 197,641 | 2,362,000 | 0.18% | ||
| 29 | Bank of New York Mellon Corp | 196,264 | 2,346,000 | 0.18% | ||
| 30 | BANK OF AMERICA CORP /DE/ | 194,341 | 2,323,000 | 0.17% | ||
| 31 | Gotham Asset Management, LLC | 189,317 | 2,262,000 | 0.17% | ||
| 32 | GOLDMAN SACHS GROUP INC | 187,836 | 2,245,000 | 0.17% | ||
| 33 | RUSSELL FRANK CO/ | 162,369 | 1,941,000 | 0.15% | ||
| 34 | TIAA CREF INVESTMENT MANAGEMENT LLC | 152,774 | 1,826,000 | 0.14% | ||
| 35 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 152,468 | 1,822,000 | 0.14% | ||
| 36 | Candriam S.C.A. | 153,000 | 1,818,000 | 0.14% | ||
| 37 | LAZARD ASSET MANAGEMENT LLC | 147,384 | 1,761,000 | 0.13% | ||
| 38 | BlackRock Investment Management, LLC | 147,003 | 1,757,000 | 0.13% | ||
| 39 | BALYASNY ASSET MANAGEMENT L.P. | 132,044 | 1,578,000 | 0.12% | ||
| 40 | JPMORGAN CHASE & CO | 130,993 | 1,565,000 | 0.12% | ||
| 41 | Airain ltd | 109,686 | 1,311,000 | 0.10% | ||
| 42 | CREDIT SUISSE AG/ | 107,978 | 1,291,000 | 0.10% | ||
| 43 | TFS CAPITAL LLC | 106,319 | 1,271,000 | 0.10% | ||
| 44 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 91,015 | 1,088,000 | 0.08% | ||
| 45 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 88,025 | 1,052,000 | 0.08% | ||
| 46 | D. E. Shaw & Co., Inc. | 84,300 | 1,007,000 | 0.08% | ||
| 47 | Nationwide Fund Advisors | 96,641 | 1,003,000 | 0.08% | ||
| 48 | ProShare Advisors LLC | 81,790 | 977,000 | 0.07% | ||
| 49 | NEW YORK STATE COMMON RETIREMENT FUND | 79,556 | 951,000 | 0.07% | ||
| 50 | Swiss National Bank | 79,614 | 923,000 | 0.07% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
