| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Artal Group S.A. | 57,517,978 | 617,743,000 | 53.78% | ||
| 2 | FMR LLC | 15,541,961 | 166,921,000 | 14.53% | ||
| 3 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 8,389,120 | 90,099,000 | 7.84% | ||
| 4 | Ulys, L.L.C. | 4,321,214 | 46,410,000 | 4.04% | ||
| 5 | VANGUARD GROUP INC | 2,910,082 | 31,255,000 | 2.72% | ||
| 6 | STATE STREET CORP | 2,479,555 | 26,633,000 | 2.32% | ||
| 7 | BlackRock Fund Advisors | 2,435,049 | 26,152,000 | 2.28% | ||
| 8 | BRIDGER MANAGEMENT, LLC | 1,292,368 | 13,880,000 | 1.21% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 1,083,213 | 11,634,000 | 1.01% | ||
| 10 | VOYA INVESTMENT MANAGEMENT LLC | 963,285 | 10,345,000 | 0.90% | ||
| 11 | TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 776,457 | 8,339,000 | 0.73% | ||
| 12 | BALYASNY ASSET MANAGEMENT L.P. | 600,951 | 6,454,000 | 0.56% | ||
| 13 | GOLDMAN SACHS GROUP INC | 533,405 | 5,729,000 | 0.50% | ||
| 14 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 525,000 | 5,639,000 | 0.49% | ||
| 15 | MASTERS CAPITAL MANAGEMENT LLC | 500,000 | 5,370,000 | 0.47% | ||
| 16 | NORTHERN TRUST CORP | 462,527 | 4,968,000 | 0.43% | ||
| 17 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 400,000 | 4,296,000 | 0.37% | Call | |
| 18 | ACUTA CAPITAL PARTNERS, LLC | 400,000 | 4,296,000 | 0.37% | ||
| 19 | Tekla Capital Management LLC | 353,900 | 3,801,000 | 0.33% | Call | |
| 20 | Tekla Capital Management LLC | 353,900 | 3,801,000 | 0.33% | ||
| 21 | ROYCE & ASSOCIATES LP | 334,374 | 3,591,000 | 0.31% | ||
| 22 | MILLENNIUM MANAGEMENT LLC | 319,381 | 3,430,000 | 0.30% | ||
| 23 | GEODE CAPITAL MANAGEMENT, LLC | 302,765 | 3,251,000 | 0.28% | ||
| 24 | SABBY MANAGEMENT, LLC | 261,595 | 2,810,000 | 0.24% | ||
| 25 | DEUTSCHE BANK AG\ | 220,112 | 2,362,000 | 0.21% | ||
| 26 | Bank of New York Mellon Corp | 201,989 | 2,169,000 | 0.19% | ||
| 27 | Rhenman & Partners Asset Management AB | 200,000 | 2,148,000 | 0.19% | ||
| 28 | TIAA CREF INVESTMENT MANAGEMENT LLC | 187,788 | 2,017,000 | 0.18% | ||
| 29 | GOLDMAN SACHS GROUP INC | 182,300 | 1,958,000 | 0.17% | Call | |
| 30 | NORGES BANK | 158,669 | 1,704,000 | 0.15% | ||
| 31 | OXFORD ASSET MANAGEMENT LLP | 147,789 | 1,587,000 | 0.14% | ||
| 32 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 144,755 | 1,555,000 | 0.14% | ||
| 33 | BlackRock Investment Management, LLC | 144,663 | 1,554,000 | 0.14% | ||
| 34 | JPMORGAN CHASE & CO | 137,693 | 1,479,000 | 0.13% | ||
| 35 | Invesco Ltd. | 131,768 | 1,415,000 | 0.12% | ||
| 36 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 93,501 | 1,004,000 | 0.09% | ||
| 37 | ProShare Advisors LLC | 82,992 | 891,000 | 0.08% | ||
| 38 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 76,300 | 819,000 | 0.07% | Put | |
| 39 | ALLIANCEBERNSTEIN L.P. | 76,101 | 817,000 | 0.07% | ||
| 40 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 75,575 | 812,000 | 0.07% | ||
| 41 | STIFEL FINANCIAL CORP | 68,478 | 735,000 | 0.06% | ||
| 42 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 66,756 | 717,000 | 0.06% | ||
| 43 | Swiss National Bank | 66,114 | 710,000 | 0.06% | ||
| 44 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 65,000 | 698,000 | 0.06% | ||
| 45 | Nationwide Fund Advisors | 62,430 | 670,000 | 0.06% | ||
| 46 | TEACHERS ADVISORS, LLC | 60,041 | 645,000 | 0.06% | ||
| 47 | BANK OF AMERICA CORP /DE/ | 59,505 | 639,000 | 0.06% | ||
| 48 | DekaBank Deutsche Girozentrale | 52,141 | 560,000 | 0.05% | ||
| 49 | NEW YORK STATE COMMON RETIREMENT FUND | 52,085 | 559,000 | 0.05% | ||
| 50 | CITIGROUP INC | 51,253 | 550,000 | 0.05% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
