| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Artal Group S.A. | 57,517,977 | 825,383,000 | 51.52% | ||
| 2 | FMR LLC | 15,573,212 | 223,476,000 | 13.95% | ||
| 3 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 6,570,712 | 94,289,000 | 5.88% | ||
| 4 | Ulys, L.L.C. | 4,321,214 | 62,009,000 | 3.87% | ||
| 5 | VANGUARD GROUP INC | 3,366,813 | 48,314,000 | 3.02% | ||
| 6 | NEA Management Company, LLC | 2,382,286 | 34,186,000 | 2.13% | ||
| 7 | BlackRock Fund Advisors | 2,343,999 | 33,636,000 | 2.10% | ||
| 8 | EAGLE ASSET MANAGEMENT INC | 1,678,732 | 24,089,000 | 1.50% | ||
| 9 | STATE STREET CORP | 1,282,614 | 18,406,000 | 1.15% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 1,094,398 | 15,705,000 | 0.98% | ||
| 11 | LOOMIS SAYLES & CO L P | 1,074,204 | 15,415,000 | 0.96% | ||
| 12 | BRIDGER MANAGEMENT, LLC | 1,029,926 | 14,779,000 | 0.92% | ||
| 13 | TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 966,257 | 13,866,000 | 0.87% | ||
| 14 | NORGES BANK | 780,489 | 11,200,000 | 0.70% | ||
| 15 | HANCOCK WHITNEY CORP | 664,025 | 9,529,000 | 0.59% | ||
| 16 | Invesco Ltd. | 616,278 | 8,844,000 | 0.55% | ||
| 17 | NORTHERN TRUST CORP | 535,788 | 7,689,000 | 0.48% | ||
| 18 | VOYA INVESTMENT MANAGEMENT LLC | 532,302 | 7,638,000 | 0.48% | ||
| 19 | COLUMBUS CIRCLE INVESTORS | 494,322 | 7,094,000 | 0.44% | ||
| 20 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 494,380 | 7,094,000 | 0.44% | ||
| 21 | MILLENNIUM MANAGEMENT LLC | 447,199 | 6,417,000 | 0.40% | ||
| 22 | GEODE CAPITAL MANAGEMENT, LLC | 416,357 | 5,974,000 | 0.37% | ||
| 23 | OXFORD ASSET MANAGEMENT LLP | 387,383 | 5,559,000 | 0.35% | ||
| 24 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 305,203 | 4,380,000 | 0.27% | ||
| 25 | Gotham Asset Management, LLC | 295,094 | 4,235,000 | 0.26% | ||
| 26 | FALCON POINT CAPITAL, LLC | 287,809 | 4,130,000 | 0.26% | ||
| 27 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 271,500 | 3,896,000 | 0.24% | Call | |
| 28 | BARCLAYS PLC | 259,000 | 3,717,000 | 0.23% | Put | |
| 29 | EMERALD ACQUISITION LTD. | 242,456 | 3,479,000 | 0.22% | ||
| 30 | WELLINGTON MANAGEMENT GROUP LLP | 239,177 | 3,432,000 | 0.21% | ||
| 31 | TIAA CREF INVESTMENT MANAGEMENT LLC | 212,427 | 3,048,000 | 0.19% | ||
| 32 | BANK OF AMERICA CORP /DE/ | 198,690 | 2,851,000 | 0.18% | ||
| 33 | D. E. Shaw & Co., Inc. | 197,303 | 2,831,000 | 0.18% | ||
| 34 | Bank of New York Mellon Corp | 194,166 | 2,786,000 | 0.17% | ||
| 35 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 188,425 | 2,703,000 | 0.17% | ||
| 36 | BALYASNY ASSET MANAGEMENT L.P. | 181,114 | 2,599,000 | 0.16% | ||
| 37 | BlackRock Investment Management, LLC | 155,715 | 2,235,000 | 0.14% | ||
| 38 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 154,300 | 2,214,000 | 0.14% | Put | |
| 39 | AMERICAN CENTURY COMPANIES INC | 152,914 | 2,194,000 | 0.14% | ||
| 40 | ALLIANCEBERNSTEIN L.P. | 143,260 | 2,056,000 | 0.13% | ||
| 41 | Candriam S.C.A. | 128,000 | 1,837,000 | 0.11% | ||
| 42 | JPMORGAN CHASE & CO | 124,693 | 1,789,000 | 0.11% | ||
| 43 | Convergence Investment Partners, LLC | 114,157 | 1,638,000 | 0.10% | ||
| 44 | GSA CAPITAL PARTNERS LLP | 103,580 | 1,486,000 | 0.09% | ||
| 45 | AQR CAPITAL MANAGEMENT LLC | 103,077 | 1,479,000 | 0.09% | ||
| 46 | GOLDMAN SACHS GROUP INC | 100,000 | 1,435,000 | 0.09% | Call | |
| 47 | GOLDMAN SACHS GROUP INC | 100,000 | 1,435,000 | 0.09% | Put | |
| 48 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 93,039 | 1,335,000 | 0.08% | ||
| 49 | FIRST TRUST ADVISORS LP | 90,926 | 1,305,000 | 0.08% | ||
| 50 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 88,627 | 1,272,000 | 0.08% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
