| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 4,085,600 | 82,733,000 | 20.95% | ||
| 2 | BVF INC/IL | 2,895,251 | 58,629,000 | 14.85% | ||
| 3 | PFM Health Sciences, LP | 1,646,516 | 33,342,000 | 8.44% | ||
| 4 | WELLINGTON MANAGEMENT GROUP LLP | 1,149,078 | 23,270,000 | 5.89% | ||
| 5 | BlackRock Fund Advisors | 871,793 | 17,654,000 | 4.47% | ||
| 6 | FIL Ltd | 803,559 | 16,272,000 | 4.12% | ||
| 7 | RS INVESTMENT MANAGEMENT CO LLC | 777,880 | 15,752,000 | 3.99% | ||
| 8 | DRIEHAUS CAPITAL MANAGEMENT LLC | 760,303 | 15,396,000 | 3.90% | ||
| 9 | BOXER CAPITAL, LLC | 705,159 | 14,279,000 | 3.62% | ||
| 10 | PRICE T ROWE ASSOCIATES INC /MD/ | 594,983 | 12,048,000 | 3.05% | ||
| 11 | VANGUARD GROUP INC | 566,995 | 11,481,000 | 2.91% | ||
| 12 | PUTNAM INVESTMENTS LLC | 488,222 | 9,886,000 | 2.50% | ||
| 13 | PERCEPTIVE ADVISORS LLC | 464,404 | 9,404,000 | 2.38% | ||
| 14 | CASDIN CAPITAL, LLC | 340,000 | 6,885,000 | 1.74% | ||
| 15 | BlackRock Institutional Trust Company, N.A. | 328,630 | 6,655,000 | 1.69% | ||
| 16 | STATE STREET CORP | 325,396 | 6,587,000 | 1.67% | ||
| 17 | EVENTIDE ASSET MANAGEMENT, LLC | 265,000 | 5,366,000 | 1.36% | ||
| 18 | Opaleye Management Inc. | 250,000 | 5,063,000 | 1.28% | ||
| 19 | NORTHERN TRUST CORP | 213,313 | 4,320,000 | 1.09% | ||
| 20 | LORD, ABBETT & CO. LLC | 210,581 | 4,264,000 | 1.08% | ||
| 21 | Alyeska Investment Group, L.P. | 183,740 | 3,721,000 | 0.94% | ||
| 22 | JPMORGAN CHASE & CO | 159,400 | 3,228,000 | 0.82% | ||
| 23 | Spark Investment Management LLC | 144,500 | 2,926,000 | 0.74% | ||
| 24 | Cormorant Asset Management, LP | 101,226 | 2,050,000 | 0.52% | ||
| 25 | GEODE CAPITAL MANAGEMENT, LLC | 96,381 | 1,951,000 | 0.49% | ||
| 26 | BlackRock Investment Management, LLC | 77,036 | 1,560,000 | 0.40% | ||
| 27 | Bank of New York Mellon Corp | 70,750 | 1,433,000 | 0.36% | ||
| 28 | DEUTSCHE BANK AG\ | 66,716 | 1,348,000 | 0.34% | ||
| 29 | TIAA CREF INVESTMENT MANAGEMENT LLC | 64,067 | 1,297,000 | 0.33% | ||
| 30 | HILLHOUSE INVESTMENT MANAGEMENT, LTD. | 52,250 | 1,058,000 | 0.27% | ||
| 31 | PANAGORA ASSET MANAGEMENT INC | 48,067 | 973,000 | 0.25% | ||
| 32 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 43,823 | 888,000 | 0.22% | ||
| 33 | NBW CAPITAL LLC | 42,998 | 871,000 | 0.22% | ||
| 34 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 41,962 | 850,000 | 0.22% | ||
| 35 | TEACHERS ADVISORS, LLC | 32,051 | 649,000 | 0.16% | ||
| 36 | MORGAN STANLEY | 31,366 | 635,000 | 0.16% | ||
| 37 | Swiss National Bank | 30,200 | 612,000 | 0.15% | ||
| 38 | Redmile Group, LLC | 28,353 | 574,000 | 0.15% | ||
| 39 | PICTET ASSET MANAGEMENT LTD | 28,151 | 535,000 | 0.14% | ||
| 40 | CREDIT SUISSE AG/ | 25,588 | 519,000 | 0.13% | ||
| 41 | MACKENZIE FINANCIAL CORP | 23,800 | 482,000 | 0.12% | ||
| 42 | ProShare Advisors LLC | 22,726 | 460,000 | 0.12% | ||
| 43 | AMERICAN CENTURY COMPANIES INC | 22,452 | 455,000 | 0.12% | ||
| 44 | DEERE & CO | 21,635 | 438,000 | 0.11% | ||
| 45 | NEW YORK STATE COMMON RETIREMENT FUND | 20,500 | 415,000 | 0.11% | ||
| 46 | Partner Investment Management, L.P. | 20,049 | 406,000 | 0.10% | ||
| 47 | HAMILTON LANE ADVISORS LLC | 21,034 | 399,000 | 0.10% | ||
| 48 | ALLIANCEBERNSTEIN L.P. | 18,100 | 367,000 | 0.09% | ||
| 49 | TFS CAPITAL LLC | 17,478 | 354,000 | 0.09% | ||
| 50 | RHUMBLINE ADVISERS | 16,241 | 329,000 | 0.08% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
