| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Third Rock Ventures, LLC | 7,393,059 | 195,842,000 | 32.81% | ||
| 2 | FMR LLC | 4,066,710 | 107,727,000 | 18.05% | ||
| 3 | BVF INC/IL | 1,582,408 | 41,918,000 | 7.02% | ||
| 4 | WELLINGTON MANAGEMENT GROUP LLP | 1,140,878 | 30,034,000 | 5.03% | ||
| 5 | Visium Asset Management, LP | 945,000 | 25,033,000 | 4.19% | ||
| 6 | RA CAPITAL MANAGEMENT, L.P. | 878,348 | 23,267,000 | 3.90% | ||
| 7 | PFM Health Sciences, LP | 862,165 | 20,916,000 | 3.50% | ||
| 8 | LORD, ABBETT & CO. LLC | 735,419 | 19,481,000 | 3.26% | ||
| 9 | CITADEL ADVISORS LLC | 683,584 | 18,108,000 | 3.03% | ||
| 10 | PRICE T ROWE ASSOCIATES INC /MD/ | 503,550 | 13,339,000 | 2.23% | ||
| 11 | RS INVESTMENT MANAGEMENT CO LLC | 492,510 | 13,047,000 | 2.19% | ||
| 12 | PERCEPTIVE ADVISORS LLC | 404,404 | 10,712,000 | 1.79% | ||
| 13 | Redmile Group, LLC | 378,235 | 9,671,000 | 1.62% | ||
| 14 | SABBY MANAGEMENT, LLC | 301,804 | 7,995,000 | 1.34% | ||
| 15 | JPMORGAN CHASE & CO | 261,850 | 6,937,000 | 1.16% | ||
| 16 | BlackRock Fund Advisors | 245,255 | 6,497,000 | 1.09% | ||
| 17 | AMERIPRISE FINANCIAL INC | 196,096 | 5,194,000 | 0.87% | ||
| 18 | VANGUARD GROUP INC | 184,871 | 4,897,000 | 0.82% | ||
| 19 | BlackRock Institutional Trust Company, N.A. | 122,260 | 3,239,000 | 0.54% | ||
| 20 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 119,279 | 3,160,000 | 0.53% | ||
| 21 | Cormorant Asset Management, LP | 100,000 | 2,649,000 | 0.44% | ||
| 22 | PUTNAM INVESTMENTS LLC | 99,300 | 2,630,000 | 0.44% | ||
| 23 | MILLENNIUM MANAGEMENT LLC | 80,200 | 2,124,000 | 0.36% | ||
| 24 | ArrowMark Colorado Holdings LLC | 78,612 | 2,082,000 | 0.35% | ||
| 25 | STATE STREET CORP | 76,630 | 2,029,000 | 0.34% | ||
| 26 | Alyeska Investment Group, L.P. | 76,235 | 2,019,000 | 0.34% | ||
| 27 | GLG LLC | 59,979 | 1,589,000 | 0.27% | ||
| 28 | TIAA CREF INVESTMENT MANAGEMENT LLC | 52,066 | 1,379,000 | 0.23% | ||
| 29 | NBW CAPITAL LLC | 47,985 | 1,271,000 | 0.21% | ||
| 30 | ARROWGRASS CAPITAL PARTNERS (US) LP | 42,588 | 1,128,000 | 0.19% | ||
| 31 | D. E. Shaw & Co., Inc. | 34,191 | 906,000 | 0.15% | ||
| 32 | BlackRock Investment Management, LLC | 33,248 | 881,000 | 0.15% | ||
| 33 | Bank of New York Mellon Corp | 33,016 | 874,000 | 0.15% | ||
| 34 | BLACKROCK ADVISORS LLC | 32,578 | 863,000 | 0.14% | ||
| 35 | NORTHERN TRUST CORP | 28,063 | 744,000 | 0.12% | ||
| 36 | GLG Partners LP | 25,587 | 678,000 | 0.11% | ||
| 37 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 22,634 | 600,000 | 0.10% | ||
| 38 | Nuveen Asset Management, LLC | 20,486 | 543,000 | 0.09% | ||
| 39 | NORGES BANK | 20,000 | 530,000 | 0.09% | ||
| 40 | GOLDMAN SACHS GROUP INC | 18,867 | 500,000 | 0.08% | ||
| 41 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 17,109 | 453,000 | 0.08% | ||
| 42 | ALLIANCEBERNSTEIN L.P. | 14,300 | 379,000 | 0.06% | ||
| 43 | TEACHERS ADVISORS, LLC | 13,638 | 361,000 | 0.06% | ||
| 44 | TD ASSET MANAGEMENT INC | 13,000 | 344,000 | 0.06% | ||
| 45 | METROPOLITAN LIFE INSURANCE CO/NY | 8,954 | 237,000 | 0.04% | ||
| 46 | UBS Group AG | 7,825 | 207,000 | 0.03% | ||
| 47 | RHUMBLINE ADVISERS | 7,710 | 204,000 | 0.03% | ||
| 48 | Partner Investment Management, L.P. | 7,350 | 195,000 | 0.03% | ||
| 49 | BlackRock Group LTD | 6,724 | 178,000 | 0.03% | ||
| 50 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 6,640 | 176,000 | 0.03% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
