| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Third Rock Ventures, LLC | 7,393,059 | 157,768,000 | 31.01% | ||
| 2 | FMR LLC | 4,066,818 | 86,786,000 | 17.06% | ||
| 3 | BVF INC/IL | 1,702,654 | 36,335,000 | 7.14% | ||
| 4 | WELLINGTON MANAGEMENT GROUP LLP | 1,265,173 | 26,999,000 | 5.31% | ||
| 5 | Visium Asset Management, LP | 1,020,000 | 21,767,000 | 4.28% | ||
| 6 | PFM Health Sciences, LP | 1,027,553 | 21,030,000 | 4.13% | ||
| 7 | RA CAPITAL MANAGEMENT, L.P. | 878,348 | 18,744,000 | 3.68% | ||
| 8 | LORD, ABBETT & CO. LLC | 643,162 | 13,725,000 | 2.70% | ||
| 9 | RS INVESTMENT MANAGEMENT CO LLC | 630,432 | 13,453,000 | 2.64% | ||
| 10 | DRIEHAUS CAPITAL MANAGEMENT LLC | 586,959 | 12,526,000 | 2.46% | ||
| 11 | CITADEL ADVISORS LLC | 546,991 | 11,673,000 | 2.29% | ||
| 12 | PRICE T ROWE ASSOCIATES INC /MD/ | 498,149 | 10,630,000 | 2.09% | ||
| 13 | PERCEPTIVE ADVISORS LLC | 404,404 | 8,629,000 | 1.70% | ||
| 14 | Redmile Group, LLC | 367,485 | 7,842,000 | 1.54% | ||
| 15 | SABBY MANAGEMENT, LLC | 308,504 | 6,583,000 | 1.29% | ||
| 16 | BlackRock Fund Advisors | 241,810 | 5,160,000 | 1.01% | ||
| 17 | VANGUARD GROUP INC | 215,576 | 4,600,000 | 0.90% | ||
| 18 | DEUTSCHE BANK AG\ | 183,971 | 3,924,000 | 0.77% | ||
| 19 | BlackRock Institutional Trust Company, N.A. | 150,459 | 3,211,000 | 0.63% | ||
| 20 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 134,921 | 2,879,000 | 0.57% | ||
| 21 | Opaleye Management Inc. | 130,000 | 2,774,000 | 0.55% | ||
| 22 | STATE STREET CORP | 116,176 | 2,477,000 | 0.49% | ||
| 23 | EVENTIDE ASSET MANAGEMENT, LLC | 107,000 | 2,283,000 | 0.45% | ||
| 24 | NORTHERN TRUST CORP | 106,315 | 2,269,000 | 0.45% | ||
| 25 | Cormorant Asset Management, LP | 100,000 | 2,134,000 | 0.42% | ||
| 26 | PUTNAM INVESTMENTS LLC | 99,300 | 2,119,000 | 0.42% | ||
| 27 | JPMORGAN CHASE & CO | 91,523 | 1,953,000 | 0.38% | ||
| 28 | AMERIPRISE FINANCIAL INC | 88,607 | 1,883,000 | 0.37% | ||
| 29 | Alyeska Investment Group, L.P. | 83,914 | 1,791,000 | 0.35% | ||
| 30 | CITIGROUP INC | 76,495 | 1,633,000 | 0.32% | ||
| 31 | ArrowMark Colorado Holdings LLC | 73,360 | 1,566,000 | 0.31% | ||
| 32 | GEODE CAPITAL MANAGEMENT, LLC | 68,108 | 1,453,000 | 0.29% | ||
| 33 | NBW CAPITAL LLC | 47,974 | 1,024,000 | 0.20% | ||
| 34 | MILLENNIUM MANAGEMENT LLC | 35,000 | 747,000 | 0.15% | ||
| 35 | BlackRock Investment Management, LLC | 32,525 | 694,000 | 0.14% | ||
| 36 | TIAA CREF INVESTMENT MANAGEMENT LLC | 31,706 | 677,000 | 0.13% | ||
| 37 | BLACKROCK ADVISORS LLC | 31,590 | 674,000 | 0.13% | ||
| 38 | GLG LLC | 30,000 | 640,000 | 0.13% | ||
| 39 | Bank of New York Mellon Corp | 27,530 | 587,000 | 0.12% | ||
| 40 | MORGAN STANLEY | 27,508 | 587,000 | 0.12% | ||
| 41 | GLG Partners LP | 26,858 | 573,000 | 0.11% | ||
| 42 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 24,343 | 520,000 | 0.10% | ||
| 43 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 17,009 | 363,000 | 0.07% | ||
| 44 | ALLIANCEBERNSTEIN L.P. | 15,400 | 329,000 | 0.06% | ||
| 45 | TEACHERS ADVISORS, LLC | 13,638 | 291,000 | 0.06% | ||
| 46 | TD ASSET MANAGEMENT INC | 13,100 | 280,000 | 0.06% | ||
| 47 | NEW YORK STATE COMMON RETIREMENT FUND | 10,300 | 220,000 | 0.04% | ||
| 48 | Partner Investment Management, L.P. | 10,154 | 217,000 | 0.04% | ||
| 49 | Virtu KCG Holdings LLC | 9,922 | 212,000 | 0.04% | ||
| 50 | GOLDMAN SACHS GROUP INC | 9,620 | 205,000 | 0.04% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
