| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 3,878,140 | 108,782,000 | 14.88% | ||
| 2 | BVF INC/IL | 3,255,280 | 91,311,000 | 12.49% | ||
| 3 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,842,415 | 51,680,000 | 7.07% | ||
| 4 | WELLINGTON MANAGEMENT GROUP LLP | 1,271,961 | 35,678,000 | 4.88% | ||
| 5 | LORD, ABBETT & CO. LLC | 1,080,574 | 30,310,000 | 4.15% | ||
| 6 | DRIEHAUS CAPITAL MANAGEMENT LLC | 1,061,625 | 29,779,000 | 4.07% | ||
| 7 | BlackRock Fund Advisors | 1,025,225 | 28,758,000 | 3.93% | ||
| 8 | VANGUARD GROUP INC | 907,265 | 25,448,000 | 3.48% | ||
| 9 | Opaleye Management Inc. | 880,000 | 24,684,000 | 3.38% | ||
| 10 | Cormorant Asset Management, LP | 841,752 | 23,611,000 | 3.23% | ||
| 11 | PFM Health Sciences, LP | 799,951 | 22,439,000 | 3.07% | ||
| 12 | PRICE T ROWE ASSOCIATES INC /MD/ | 739,502 | 20,743,000 | 2.84% | ||
| 13 | BOXER CAPITAL, LLC | 705,159 | 19,780,000 | 2.71% | ||
| 14 | SANDIA HOLDINGS, LLC | 700,991 | 19,663,000 | 2.69% | ||
| 15 | STATE STREET CORP | 681,891 | 19,125,000 | 2.62% | ||
| 16 | VICTORY CAPITAL MANAGEMENT INC | 660,150 | 18,517,000 | 2.53% | ||
| 17 | BlackRock Institutional Trust Company, N.A. | 573,342 | 16,082,000 | 2.20% | ||
| 18 | HILLHOUSE INVESTMENT MANAGEMENT, LTD. | 482,455 | 13,533,000 | 1.85% | ||
| 19 | PICTET ASSET MANAGEMENT LTD | 391,173 | 10,972,000 | 1.50% | ||
| 20 | FORESITE CAPITAL MANAGEMENT III, LLC | 300,000 | 8,415,000 | 1.15% | ||
| 21 | PERCEPTIVE ADVISORS LLC | 273,820 | 7,680,000 | 1.05% | ||
| 22 | EVENTIDE ASSET MANAGEMENT, LLC | 265,000 | 7,433,000 | 1.02% | ||
| 23 | FIL Ltd | 256,997 | 7,209,000 | 0.99% | ||
| 24 | CASDIN CAPITAL, LLC | 244,500 | 6,858,000 | 0.94% | ||
| 25 | NORTHERN TRUST CORP | 244,493 | 6,858,000 | 0.94% | ||
| 26 | GEODE CAPITAL MANAGEMENT, LLC | 227,898 | 6,392,000 | 0.87% | ||
| 27 | FRANKLIN RESOURCES INC | 200,000 | 5,610,000 | 0.77% | ||
| 28 | JPMORGAN CHASE & CO | 166,893 | 4,681,000 | 0.64% | ||
| 29 | Alyeska Investment Group, L.P. | 100,000 | 2,805,000 | 0.38% | ||
| 30 | PUTNAM INVESTMENTS LLC | 98,700 | 2,769,000 | 0.38% | ||
| 31 | MORGAN STANLEY | 94,493 | 2,651,000 | 0.36% | ||
| 32 | Bank of New York Mellon Corp | 93,473 | 2,622,000 | 0.36% | ||
| 33 | GOLDMAN SACHS GROUP INC | 93,309 | 2,617,000 | 0.36% | ||
| 34 | Spark Investment Management LLC | 91,900 | 2,577,000 | 0.35% | ||
| 35 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 84,152 | 2,361,000 | 0.32% | ||
| 36 | MONASHEE INVESTMENT MANAGEMENT LLC | 80,000 | 2,244,000 | 0.31% | ||
| 37 | BlackRock Investment Management, LLC | 77,162 | 2,164,000 | 0.30% | ||
| 38 | CITADEL ADVISORS LLC | 74,711 | 2,096,000 | 0.29% | ||
| 39 | DAFNA Capital Management LLC | 72,500 | 2,034,000 | 0.28% | ||
| 40 | CITIGROUP INC | 65,854 | 1,847,000 | 0.25% | ||
| 41 | Laurion Capital Management LP | 60,106 | 1,686,000 | 0.23% | ||
| 42 | NBW CAPITAL LLC | 59,582 | 1,671,000 | 0.23% | ||
| 43 | TIAA CREF INVESTMENT MANAGEMENT LLC | 57,633 | 1,617,000 | 0.22% | ||
| 44 | TUDOR INVESTMENT CORP ET AL | 42,559 | 1,194,000 | 0.16% | ||
| 45 | Swiss National Bank | 41,300 | 1,158,000 | 0.16% | ||
| 46 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 41,262 | 1,157,000 | 0.16% | ||
| 47 | D. E. Shaw & Co., Inc. | 38,097 | 1,069,000 | 0.15% | ||
| 48 | Foundry Partners, LLC | 37,616 | 1,055,000 | 0.14% | ||
| 49 | Allianz Asset Management GmbH | 37,533 | 1,053,000 | 0.14% | ||
| 50 | TEACHERS ADVISORS, LLC | 32,932 | 924,000 | 0.13% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
