| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 3,516,473 | 92,624,000 | 19.10% | ||
| 2 | BVF INC/IL | 2,278,459 | 60,015,000 | 12.37% | ||
| 3 | Visium Asset Management, LP | 1,020,000 | 26,867,000 | 5.54% | ||
| 4 | PFM Health Sciences, LP | 1,008,232 | 26,557,000 | 5.48% | ||
| 5 | RA CAPITAL MANAGEMENT, L.P. | 878,348 | 23,136,000 | 4.77% | ||
| 6 | FIL Ltd | 803,559 | 21,166,000 | 4.36% | ||
| 7 | LORD, ABBETT & CO. LLC | 751,715 | 19,800,000 | 4.08% | ||
| 8 | RS INVESTMENT MANAGEMENT CO LLC | 740,310 | 19,500,000 | 4.02% | ||
| 9 | DRIEHAUS CAPITAL MANAGEMENT LLC | 680,160 | 17,915,000 | 3.69% | ||
| 10 | BlackRock Fund Advisors | 570,657 | 15,031,000 | 3.10% | ||
| 11 | PRICE T ROWE ASSOCIATES INC /MD/ | 533,848 | 14,062,000 | 2.90% | ||
| 12 | VANGUARD GROUP INC | 504,456 | 13,287,000 | 2.74% | ||
| 13 | WELLINGTON MANAGEMENT GROUP LLP | 473,001 | 12,459,000 | 2.57% | ||
| 14 | CASDIN CAPITAL, LLC | 412,500 | 10,865,000 | 2.24% | ||
| 15 | PERCEPTIVE ADVISORS LLC | 404,404 | 10,652,000 | 2.20% | ||
| 16 | PUTNAM INVESTMENTS LLC | 343,777 | 9,055,000 | 1.87% | ||
| 17 | BOXER CAPITAL, LLC | 313,626 | 8,261,000 | 1.70% | ||
| 18 | GOLDMAN SACHS GROUP INC | 300,000 | 7,902,000 | 1.63% | Call | |
| 19 | Redmile Group, LLC | 276,687 | 7,288,000 | 1.50% | ||
| 20 | Opaleye Management Inc. | 275,000 | 7,244,000 | 1.49% | ||
| 21 | EVENTIDE ASSET MANAGEMENT, LLC | 246,500 | 6,493,000 | 1.34% | ||
| 22 | BlackRock Institutional Trust Company, N.A. | 214,416 | 5,648,000 | 1.16% | ||
| 23 | CITADEL ADVISORS LLC | 137,303 | 3,617,000 | 0.75% | ||
| 24 | STATE STREET CORP | 129,306 | 3,407,000 | 0.70% | ||
| 25 | Spot Trading L.L.C | 125,000 | 3,293,000 | 0.68% | Call | |
| 26 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 124,431 | 3,278,000 | 0.68% | ||
| 27 | DEUTSCHE BANK AG\ | 118,247 | 3,112,000 | 0.64% | ||
| 28 | AMERIPRISE FINANCIAL INC | 111,752 | 2,943,000 | 0.61% | ||
| 29 | NORTHERN TRUST CORP | 110,542 | 2,912,000 | 0.60% | ||
| 30 | Cormorant Asset Management, LP | 100,000 | 2,634,000 | 0.54% | ||
| 31 | GOLDMAN SACHS GROUP INC | 93,719 | 2,469,000 | 0.51% | ||
| 32 | CITIGROUP INC | 85,163 | 2,243,000 | 0.46% | ||
| 33 | JPMORGAN CHASE & CO | 79,250 | 2,088,000 | 0.43% | ||
| 34 | Alyeska Investment Group, L.P. | 74,281 | 1,957,000 | 0.40% | ||
| 35 | GEODE CAPITAL MANAGEMENT, LLC | 69,802 | 1,838,000 | 0.38% | ||
| 36 | NBW CAPITAL LLC | 44,620 | 1,175,000 | 0.24% | ||
| 37 | Bank of New York Mellon Corp | 40,417 | 1,064,000 | 0.22% | ||
| 38 | BlackRock Investment Management, LLC | 32,708 | 862,000 | 0.18% | ||
| 39 | TIAA CREF INVESTMENT MANAGEMENT LLC | 31,706 | 835,000 | 0.17% | ||
| 40 | MORGAN STANLEY | 30,697 | 809,000 | 0.17% | ||
| 41 | Trexquant Investment LP | 28,914 | 762,000 | 0.16% | ||
| 42 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 24,993 | 659,000 | 0.14% | ||
| 43 | A.R.T. Advisors, LLC | 24,491 | 645,000 | 0.13% | ||
| 44 | ProShare Advisors LLC | 23,157 | 610,000 | 0.13% | ||
| 45 | Partner Investment Management, L.P. | 18,052 | 475,000 | 0.10% | ||
| 46 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 17,371 | 458,000 | 0.09% | ||
| 47 | ALLIANCEBERNSTEIN L.P. | 20,600 | 440,000 | 0.09% | ||
| 48 | MACKENZIE FINANCIAL CORP | 14,500 | 382,000 | 0.08% | ||
| 49 | Swiss National Bank | 14,200 | 374,000 | 0.08% | ||
| 50 | TEACHERS ADVISORS, LLC | 13,638 | 359,000 | 0.07% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
