| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 4,069,985 | 73,463,000 | 22.33% | ||
| 2 | BVF INC/IL | 2,640,251 | 47,657,000 | 14.49% | ||
| 3 | PFM Health Sciences, LP | 1,420,511 | 25,640,000 | 7.79% | ||
| 4 | Visium Asset Management, LP | 1,265,025 | 22,834,000 | 6.94% | ||
| 5 | FIL Ltd | 803,559 | 14,504,000 | 4.41% | ||
| 6 | RS INVESTMENT MANAGEMENT CO LLC | 787,401 | 14,213,000 | 4.32% | ||
| 7 | BOXER CAPITAL, LLC | 705,159 | 12,728,000 | 3.87% | ||
| 8 | DRIEHAUS CAPITAL MANAGEMENT LLC | 661,717 | 11,944,000 | 3.63% | ||
| 9 | BlackRock Fund Advisors | 594,012 | 10,722,000 | 3.26% | ||
| 10 | WELLINGTON MANAGEMENT GROUP LLP | 536,416 | 9,682,000 | 2.94% | ||
| 11 | VANGUARD GROUP INC | 527,742 | 9,526,000 | 2.90% | ||
| 12 | PRICE T ROWE ASSOCIATES INC /MD/ | 511,808 | 9,238,000 | 2.81% | ||
| 13 | PUTNAM INVESTMENTS LLC | 462,997 | 8,357,000 | 2.54% | ||
| 14 | PERCEPTIVE ADVISORS LLC | 404,404 | 7,299,000 | 2.22% | ||
| 15 | CASDIN CAPITAL, LLC | 321,300 | 5,799,000 | 1.76% | ||
| 16 | GOLDMAN SACHS GROUP INC | 300,000 | 5,415,000 | 1.65% | Call | |
| 17 | EVENTIDE ASSET MANAGEMENT, LLC | 246,500 | 4,449,000 | 1.35% | ||
| 18 | BlackRock Institutional Trust Company, N.A. | 231,869 | 4,185,000 | 1.27% | ||
| 19 | Opaleye Management Inc. | 220,000 | 3,971,000 | 1.21% | ||
| 20 | STATE STREET CORP | 134,258 | 2,427,000 | 0.74% | ||
| 21 | LORD, ABBETT & CO. LLC | 126,904 | 2,291,000 | 0.70% | ||
| 22 | NORTHERN TRUST CORP | 112,789 | 2,036,000 | 0.62% | ||
| 23 | Alyeska Investment Group, L.P. | 91,837 | 1,658,000 | 0.50% | ||
| 24 | Spark Investment Management LLC | 85,700 | 1,546,000 | 0.47% | ||
| 25 | JPMORGAN CHASE & CO | 80,175 | 1,447,000 | 0.44% | ||
| 26 | GEODE CAPITAL MANAGEMENT, LLC | 71,813 | 1,296,000 | 0.39% | ||
| 27 | DEUTSCHE BANK AG\ | 65,165 | 1,174,000 | 0.36% | ||
| 28 | RA CAPITAL MANAGEMENT, L.P. | 56,442 | 1,019,000 | 0.31% | ||
| 29 | Bank of New York Mellon Corp | 47,506 | 857,000 | 0.26% | ||
| 30 | GOLDMAN SACHS GROUP INC | 47,238 | 853,000 | 0.26% | ||
| 31 | AMERIPRISE FINANCIAL INC | 47,014 | 849,000 | 0.26% | ||
| 32 | NBW CAPITAL LLC | 44,079 | 796,000 | 0.24% | ||
| 33 | BlackRock Investment Management, LLC | 33,202 | 599,000 | 0.18% | ||
| 34 | TIAA CREF INVESTMENT MANAGEMENT LLC | 31,706 | 572,000 | 0.17% | ||
| 35 | Spot Trading L.L.C | 30,000 | 542,000 | 0.16% | Call | |
| 36 | SABBY MANAGEMENT, LLC | 29,624 | 535,000 | 0.16% | ||
| 37 | Swiss National Bank | 30,200 | 527,000 | 0.16% | ||
| 38 | MORGAN STANLEY | 28,888 | 521,000 | 0.16% | ||
| 39 | Redmile Group, LLC | 27,055 | 488,000 | 0.15% | ||
| 40 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 25,503 | 461,000 | 0.14% | ||
| 41 | Trexquant Investment LP | 22,216 | 401,000 | 0.12% | ||
| 42 | MACKENZIE FINANCIAL CORP | 22,100 | 399,000 | 0.12% | ||
| 43 | ProShare Advisors LLC | 21,206 | 383,000 | 0.12% | ||
| 44 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 19,853 | 358,000 | 0.11% | ||
| 45 | Partner Investment Management, L.P. | 18,788 | 339,000 | 0.10% | ||
| 46 | ALLIANCEBERNSTEIN L.P. | 16,400 | 296,000 | 0.09% | ||
| 47 | TEACHERS ADVISORS, LLC | 13,638 | 246,000 | 0.07% | ||
| 48 | TD ASSET MANAGEMENT INC | 12,300 | 222,000 | 0.07% | ||
| 49 | DekaBank Deutsche Girozentrale | 12,600 | 218,000 | 0.07% | ||
| 50 | CITIGROUP INC | 11,351 | 205,000 | 0.06% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
