| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 1,471,553 | 11,478,000 | 12.85% | ||
| 2 | INTERWEST VENTURE MANAGEMENT CO | 1,356,813 | 10,583,000 | 11.85% | ||
| 3 | FRAZIER MANAGEMENT LLC | 1,312,258 | 10,236,000 | 11.46% | ||
| 4 | BB BIOTECH AG | 1,043,824 | 8,142,000 | 9.12% | ||
| 5 | Aisling Capital LLC | 1,021,148 | 7,965,000 | 8.92% | ||
| 6 | PERCEPTIVE ADVISORS LLC | 826,369 | 6,445,000 | 7.22% | ||
| 7 | BlackRock Finance, Inc. | 579,949 | 4,525,000 | 5.07% | ||
| 8 | Broadfin Capital, LLC | 562,875 | 4,390,000 | 4.92% | ||
| 9 | Omega Fund Management, LLC | 444,965 | 3,471,000 | 3.89% | ||
| 10 | VANGUARD GROUP INC | 343,184 | 2,677,000 | 3.00% | ||
| 11 | Rock Springs Capital Management LP | 300,000 | 2,340,000 | 2.62% | ||
| 12 | Tekla Capital Management LLC | 286,472 | 2,234,000 | 2.50% | ||
| 13 | EVENTIDE ASSET MANAGEMENT, LLC | 264,000 | 2,059,000 | 2.31% | ||
| 14 | MILLENNIUM MANAGEMENT LLC | 215,284 | 1,679,000 | 1.88% | ||
| 15 | DAFNA Capital Management LLC | 208,458 | 1,626,000 | 1.82% | ||
| 16 | SABBY MANAGEMENT, LLC | 177,600 | 1,385,000 | 1.55% | ||
| 17 | STATE STREET CORP | 124,518 | 970,000 | 1.09% | ||
| 18 | Opaleye Management Inc. | 122,500 | 955,000 | 1.07% | ||
| 19 | NORTHERN TRUST CORP | 112,536 | 878,000 | 0.98% | ||
| 20 | West Family Investments, Inc. | 100,000 | 780,000 | 0.87% | ||
| 21 | Alyeska Investment Group, L.P. | 98,836 | 771,000 | 0.86% | ||
| 22 | GEODE CAPITAL MANAGEMENT, LLC | 69,547 | 542,000 | 0.61% | ||
| 23 | Bank of New York Mellon Corp | 42,350 | 330,000 | 0.37% | ||
| 24 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 40,000 | 312,000 | 0.35% | ||
| 25 | TIAA CREF INVESTMENT MANAGEMENT LLC | 39,065 | 305,000 | 0.34% | ||
| 26 | RENAISSANCE TECHNOLOGIES LLC | 35,500 | 277,000 | 0.31% | ||
| 27 | Spark Investment Management LLC | 29,200 | 227,000 | 0.25% | ||
| 28 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 25,991 | 203,000 | 0.23% | ||
| 29 | JPMORGAN CHASE & CO | 25,639 | 200,000 | 0.22% | ||
| 30 | CAXTON CORP | 20,802 | 162,000 | 0.18% | ||
| 31 | TEACHERS ADVISORS, LLC | 20,021 | 156,000 | 0.17% | ||
| 32 | MORGAN STANLEY | 18,648 | 145,000 | 0.16% | ||
| 33 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 17,159 | 134,000 | 0.15% | ||
| 34 | RHUMBLINE ADVISERS | 13,893 | 108,000 | 0.12% | ||
| 35 | NEW YORK STATE COMMON RETIREMENT FUND | 13,601 | 106,000 | 0.12% | ||
| 36 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 12,433 | 97,000 | 0.11% | ||
| 37 | Zurcher Kantonalbank (Zurich Cantonalbank) | 9,500 | 74,000 | 0.08% | ||
| 38 | WELLS FARGO & COMPANY/MN | 9,027 | 70,000 | 0.08% | ||
| 39 | Nationwide Fund Advisors | 6,609 | 52,000 | 0.06% | ||
| 40 | AMERICAN INTERNATIONAL GROUP, INC. | 6,675 | 52,000 | 0.06% | ||
| 41 | STRS OHIO | 5,800 | 45,000 | 0.05% | ||
| 42 | DEUTSCHE BANK AG\ | 3,163 | 24,000 | 0.03% | ||
| 43 | BANK OF AMERICA CORP /DE/ | 2,282 | 18,000 | 0.02% | ||
| 44 | VICTORY CAPITAL MANAGEMENT INC | 2,169 | 17,000 | 0.02% | ||
| 45 | PRELUDE CAPITAL MANAGEMENT, LLC | 1,626 | 13,000 | 0.01% | ||
| 46 | Legal & General Group Plc | 1,483 | 12,000 | 0.01% | ||
| 47 | UBS Group AG | 1,315 | 10,000 | 0.01% | ||
| 48 | Ameritas Investment Partners, Inc. | 1,075 | 8,000 | 0.01% | ||
| 49 | MEEDER ASSET MANAGEMENT INC | 625 | 5,000 | 0.01% | ||
| 50 | ROYAL BANK OF CANADA | 504 | 4,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
