| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 1,471,553 | 15,304,000 | 12.91% | ||
| 2 | INTERWEST VENTURE MANAGEMENT CO | 1,356,813 | 14,111,000 | 11.91% | ||
| 3 | FRAZIER MANAGEMENT LLC | 1,312,258 | 13,647,000 | 11.52% | ||
| 4 | BB BIOTECH AG | 1,043,824 | 10,856,000 | 9.16% | ||
| 5 | Aisling Capital LLC | 1,021,148 | 10,620,000 | 8.96% | ||
| 6 | PERCEPTIVE ADVISORS LLC | 773,369 | 8,043,000 | 6.79% | ||
| 7 | Broadfin Capital, LLC | 562,875 | 5,854,000 | 4.94% | ||
| 8 | Omega Fund Management, LLC | 495,050 | 5,149,000 | 4.34% | ||
| 9 | BlackRock Fund Advisors | 426,851 | 4,439,000 | 3.75% | ||
| 10 | VANGUARD GROUP INC | 332,472 | 3,457,000 | 2.92% | ||
| 11 | Rock Springs Capital Management LP | 300,000 | 3,120,000 | 2.63% | ||
| 12 | SABBY MANAGEMENT, LLC | 292,398 | 3,041,000 | 2.57% | ||
| 13 | EVENTIDE ASSET MANAGEMENT, LLC | 264,000 | 2,746,000 | 2.32% | ||
| 14 | AWM Investment Company, Inc. | 262,655 | 2,732,000 | 2.31% | ||
| 15 | DAFNA Capital Management LLC | 159,918 | 1,663,000 | 1.40% | ||
| 16 | Tekla Capital Management LLC | 132,472 | 1,378,000 | 1.16% | ||
| 17 | STATE STREET CORP | 109,830 | 1,142,000 | 0.96% | ||
| 18 | NORTHERN TRUST CORP | 105,922 | 1,101,000 | 0.93% | ||
| 19 | Alyeska Investment Group, L.P. | 100,000 | 1,040,000 | 0.88% | ||
| 20 | BlackRock Institutional Trust Company, N.A. | 98,117 | 1,020,000 | 0.86% | ||
| 21 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 80,000 | 832,000 | 0.70% | ||
| 22 | PUTNAM INVESTMENTS LLC | 76,900 | 800,000 | 0.68% | ||
| 23 | GEODE CAPITAL MANAGEMENT, LLC | 69,420 | 721,000 | 0.61% | ||
| 24 | MILLENNIUM MANAGEMENT LLC | 65,789 | 684,000 | 0.58% | ||
| 25 | RENAISSANCE TECHNOLOGIES LLC | 49,900 | 519,000 | 0.44% | ||
| 26 | BlackRock Investment Management, LLC | 44,776 | 466,000 | 0.39% | ||
| 27 | Bank of New York Mellon Corp | 39,703 | 413,000 | 0.35% | ||
| 28 | MORGAN STANLEY | 39,246 | 408,000 | 0.34% | ||
| 29 | TIAA CREF INVESTMENT MANAGEMENT LLC | 37,225 | 387,000 | 0.33% | ||
| 30 | TURNER INVESTMENTS LLC | 29,451 | 306,000 | 0.26% | ||
| 31 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 26,591 | 277,000 | 0.23% | ||
| 32 | CAXTON CORP | 20,358 | 212,000 | 0.18% | ||
| 33 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 20,213 | 210,000 | 0.18% | ||
| 34 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 17,159 | 179,000 | 0.15% | ||
| 35 | RUSSELL INVESTMENTS GROUP, LTD. | 16,108 | 173,000 | 0.15% | ||
| 36 | TEACHERS ADVISORS, LLC | 16,524 | 172,000 | 0.15% | ||
| 37 | NEW YORK STATE COMMON RETIREMENT FUND | 13,600 | 141,000 | 0.12% | ||
| 38 | RHUMBLINE ADVISERS | 13,285 | 138,000 | 0.12% | ||
| 39 | OXFORD ASSET MANAGEMENT LLP | 12,821 | 133,000 | 0.11% | ||
| 40 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 11,353 | 118,000 | 0.10% | ||
| 41 | WELLS FARGO & COMPANY/MN | 9,027 | 94,000 | 0.08% | ||
| 42 | BlackRock Finance, Inc. | 8,910 | 93,000 | 0.08% | ||
| 43 | DEUTSCHE BANK AG\ | 8,092 | 82,000 | 0.07% | ||
| 44 | UBS Group AG | 7,116 | 74,000 | 0.06% | ||
| 45 | Nationwide Fund Advisors | 6,609 | 69,000 | 0.06% | ||
| 46 | AMERICAN INTERNATIONAL GROUP, INC. | 6,166 | 64,000 | 0.05% | ||
| 47 | STRS OHIO | 5,800 | 60,000 | 0.05% | ||
| 48 | BLACKROCK ADVISORS LLC | 5,368 | 56,000 | 0.05% | ||
| 49 | JPMORGAN CHASE & CO | 4,615 | 48,000 | 0.04% | ||
| 50 | CITIGROUP INC | 2,251 | 23,000 | 0.02% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
