| 1 |
FMR LLC |
1,966,401 |
33,743,000 |
22.00% |
|
|
| 2 |
FRAZIER MANAGEMENT LLC |
1,312,258 |
22,518,000 |
14.68% |
|
|
| 3 |
RA CAPITAL MANAGEMENT, L.P. |
1,174,219 |
20,150,000 |
13.14% |
|
|
| 4 |
Aisling Capital LLC |
1,019,455 |
17,494,000 |
11.41% |
|
|
| 5 |
PERCEPTIVE ADVISORS LLC |
742,858 |
12,747,000 |
8.31% |
|
|
| 6 |
GOLDMAN SACHS GROUP INC |
545,804 |
9,366,000 |
6.11% |
|
|
| 7 |
BB BIOTECH AG |
466,679 |
8,008,000 |
5.22% |
|
|
| 8 |
EVENTIDE ASSET MANAGEMENT, LLC |
264,000 |
4,530,000 |
2.95% |
|
|
| 9 |
Rock Springs Capital Management LP |
250,000 |
4,290,000 |
2.80% |
|
|
| 10 |
Broadfin Capital, LLC |
166,875 |
2,864,000 |
1.87% |
|
|
| 11 |
AWM Investment Company, Inc. |
150,000 |
2,574,000 |
1.68% |
|
|
| 12 |
VANGUARD GROUP INC |
134,541 |
2,309,000 |
1.51% |
|
|
| 13 |
BlackRock Fund Advisors |
130,256 |
2,235,000 |
1.46% |
|
|
| 14 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
119,456 |
2,050,000 |
1.34% |
|
|
| 15 |
PUTNAM INVESTMENTS LLC |
100,000 |
1,716,000 |
1.12% |
|
|
| 16 |
Tekla Capital Management LLC |
52,500 |
901,000 |
0.59% |
|
|
| 17 |
NORTHERN TRUST CORP |
50,143 |
860,000 |
0.56% |
|
|
| 18 |
BlackRock Institutional Trust Company, N.A. |
35,799 |
614,000 |
0.40% |
|
|
| 19 |
STATE STREET CORP |
33,987 |
582,000 |
0.38% |
|
|
| 20 |
Spark Investment Management LLC |
32,900 |
564,000 |
0.37% |
|
|
| 21 |
GEODE CAPITAL MANAGEMENT, LLC |
26,448 |
453,000 |
0.30% |
|
|
| 22 |
OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) |
20,000 |
343,000 |
0.22% |
|
|
| 23 |
Nationwide Fund Advisors |
17,070 |
293,000 |
0.19% |
|
|
| 24 |
BlackRock Investment Management, LLC |
16,935 |
291,000 |
0.19% |
|
|
| 25 |
A.R.T. Advisors, LLC |
16,925 |
290,000 |
0.19% |
|
|
| 26 |
Bank of New York Mellon Corp |
16,349 |
280,000 |
0.18% |
|
|
| 27 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
15,388 |
264,000 |
0.17% |
|
|
| 28 |
BAILARD, INC. |
14,000 |
240,000 |
0.16% |
|
|
| 29 |
CAXTON CORP |
12,812 |
220,000 |
0.14% |
|
|
| 30 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
8,898 |
153,000 |
0.10% |
|
|
| 31 |
TEACHERS ADVISORS, LLC |
6,929 |
119,000 |
0.08% |
|
|
| 32 |
NEW YORK STATE COMMON RETIREMENT FUND |
4,400 |
76,000 |
0.05% |
|
|
| 33 |
AMERICAN INTERNATIONAL GROUP, INC. |
2,820 |
48,000 |
0.03% |
|
|
| 34 |
MORGAN STANLEY |
2,057 |
36,000 |
0.02% |
|
|
| 35 |
CITIGROUP INC |
1,454 |
25,000 |
0.02% |
|
|
| 36 |
STRS OHIO |
1,500 |
25,000 |
0.02% |
|
|
| 37 |
BLACKROCK ADVISORS LLC |
1,291 |
22,000 |
0.01% |
|
|
| 38 |
DEUTSCHE BANK AG\ |
1,191 |
20,000 |
0.01% |
|
|
| 39 |
Tower Research Capital LLC (TRC) |
716 |
12,000 |
0.01% |
|
|
| 40 |
BNP PARIBAS FINANCIAL MARKETS |
456 |
7,825 |
0.01% |
|
|
| 41 |
PRELUDE CAPITAL MANAGEMENT, LLC |
178 |
3,000 |
0.00% |
|
|
| 42 |
BANK OF AMERICA CORP /DE/ |
116 |
2,000 |
0.00% |
|
|
| 43 |
BANK OF MONTREAL /CAN/ |
97 |
2,000 |
0.00% |
|
|
| 44 |
MSI Financial Services Inc |
115 |
2,000 |
0.00% |
|
|
| 45 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
85 |
1,000 |
0.00% |
|
|
| 46 |
WELLS FARGO & COMPANY/MN |
23 |
0 |
0.00% |
|
|
