| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 1,396,553 | 15,991,000 | 17.73% | ||
| 2 | FRAZIER MANAGEMENT LLC | 1,312,258 | 15,025,000 | 16.66% | ||
| 3 | Aisling Capital LLC | 1,021,148 | 11,692,000 | 12.96% | ||
| 4 | PERCEPTIVE ADVISORS LLC | 773,369 | 8,855,000 | 9.82% | ||
| 5 | BB BIOTECH AG | 746,824 | 8,551,000 | 9.48% | ||
| 6 | BlackRock Fund Advisors | 301,434 | 3,451,000 | 3.83% | ||
| 7 | EVENTIDE ASSET MANAGEMENT, LLC | 264,000 | 3,023,000 | 3.35% | ||
| 8 | AWM Investment Company, Inc. | 262,655 | 3,007,000 | 3.33% | ||
| 9 | Rock Springs Capital Management LP | 250,000 | 2,863,000 | 3.17% | ||
| 10 | SABBY MANAGEMENT, LLC | 190,358 | 2,180,000 | 2.42% | ||
| 11 | VANGUARD GROUP INC | 185,575 | 2,125,000 | 2.36% | ||
| 12 | Broadfin Capital, LLC | 166,875 | 1,911,000 | 2.12% | ||
| 13 | Tekla Capital Management LLC | 132,472 | 1,517,000 | 1.68% | ||
| 14 | PUTNAM INVESTMENTS LLC | 100,000 | 1,145,000 | 1.27% | ||
| 15 | NORTHERN TRUST CORP | 95,764 | 1,096,000 | 1.21% | ||
| 16 | STATE STREET CORP | 91,698 | 1,047,000 | 1.16% | ||
| 17 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 80,000 | 916,000 | 1.02% | ||
| 18 | BlackRock Institutional Trust Company, N.A. | 75,925 | 869,000 | 0.96% | ||
| 19 | RENAISSANCE TECHNOLOGIES LLC | 43,500 | 498,000 | 0.55% | ||
| 20 | BlackRock Investment Management, LLC | 43,089 | 493,000 | 0.55% | ||
| 21 | GEODE CAPITAL MANAGEMENT, LLC | 38,110 | 436,000 | 0.48% | ||
| 22 | TIAA CREF INVESTMENT MANAGEMENT LLC | 35,777 | 410,000 | 0.45% | ||
| 23 | TURNER INVESTMENTS LLC | 27,451 | 314,000 | 0.35% | ||
| 24 | Bank of New York Mellon Corp | 26,181 | 300,000 | 0.33% | ||
| 25 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 22,691 | 260,000 | 0.29% | ||
| 26 | CREDIT SUISSE AG/ | 20,082 | 229,000 | 0.25% | ||
| 27 | CAXTON CORP | 18,425 | 211,000 | 0.23% | ||
| 28 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 17,159 | 197,000 | 0.22% | ||
| 29 | RHUMBLINE ADVISERS | 16,510 | 189,000 | 0.21% | ||
| 30 | EMERALD ACQUISITION LTD. | 16,108 | 185,000 | 0.21% | ||
| 31 | Spark Investment Management LLC | 15,100 | 172,000 | 0.19% | ||
| 32 | TEACHERS ADVISORS, LLC | 14,066 | 161,000 | 0.18% | ||
| 33 | NEW YORK STATE COMMON RETIREMENT FUND | 13,600 | 156,000 | 0.17% | ||
| 34 | BlackRock Finance, Inc. | 8,910 | 102,000 | 0.11% | ||
| 35 | Nationwide Fund Advisors | 6,609 | 76,000 | 0.08% | ||
| 36 | AMERICAN INTERNATIONAL GROUP, INC. | 6,183 | 70,795 | 0.08% | ||
| 37 | STRS OHIO | 5,800 | 66,000 | 0.07% | ||
| 38 | BLACKROCK ADVISORS LLC | 5,549 | 64,000 | 0.07% | ||
| 39 | TLP GROUP LLC | 5,430 | 62,000 | 0.07% | ||
| 40 | JPMORGAN CHASE & CO | 5,267 | 60,000 | 0.07% | ||
| 41 | WELLS FARGO & COMPANY/MN | 5,001 | 57,000 | 0.06% | ||
| 42 | MORGAN STANLEY | 3,669 | 42,000 | 0.05% | ||
| 43 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 3,127 | 36,000 | 0.04% | ||
| 44 | UBS Group AG | 2,664 | 31,000 | 0.03% | ||
| 45 | DEUTSCHE BANK AG\ | 1,763 | 20,000 | 0.02% | ||
| 46 | CITIGROUP INC | 1,200 | 14,000 | 0.02% | ||
| 47 | BlackRock Japan Co. Ltd | 1,165 | 13,000 | 0.01% | ||
| 48 | BNP PARIBAS FINANCIAL MARKETS | 730 | 8,359 | 0.01% | ||
| 49 | BANK OF AMERICA CORP /DE/ | 686 | 8,000 | 0.01% | ||
| 50 | Tower Research Capital LLC (TRC) | 212 | 2,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
