| 1 |
FMR LLC |
2,021,217 |
25,710,000 |
26.60% |
|
|
| 2 |
RA CAPITAL MANAGEMENT, L.P. |
1,180,570 |
15,017,000 |
15.54% |
|
|
| 3 |
Aisling Capital LLC |
1,019,458 |
12,967,000 |
13.41% |
|
|
| 4 |
PERCEPTIVE ADVISORS LLC |
742,858 |
9,449,000 |
9.78% |
|
|
| 5 |
GOLDMAN SACHS GROUP INC |
331,472 |
4,216,000 |
4.36% |
|
|
| 6 |
SABBY MANAGEMENT, LLC |
306,044 |
3,893,000 |
4.03% |
|
|
| 7 |
Rock Springs Capital Management LP |
275,000 |
3,498,000 |
3.62% |
|
|
| 8 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
237,583 |
3,022,000 |
3.13% |
|
|
| 9 |
EVENTIDE ASSET MANAGEMENT, LLC |
175,400 |
2,231,000 |
2.31% |
|
|
| 10 |
Broadfin Capital, LLC |
166,875 |
2,123,000 |
2.20% |
|
|
| 11 |
AWM Investment Company, Inc. |
132,400 |
1,684,000 |
1.74% |
|
|
| 12 |
BlackRock Fund Advisors |
129,126 |
1,642,000 |
1.70% |
|
|
| 13 |
Alyeska Investment Group, L.P. |
121,445 |
1,545,000 |
1.60% |
|
|
| 14 |
VANGUARD GROUP INC |
100,173 |
1,275,000 |
1.32% |
|
|
| 15 |
PUTNAM INVESTMENTS LLC |
100,000 |
1,272,000 |
1.32% |
|
|
| 16 |
MILLENNIUM MANAGEMENT LLC |
59,508 |
757,000 |
0.78% |
|
|
| 17 |
ACUTA CAPITAL PARTNERS, LLC |
59,127 |
752,000 |
0.78% |
|
|
| 18 |
BLACKROCK ADVISORS LLC |
51,069 |
649,000 |
0.67% |
|
|
| 19 |
Tekla Capital Management LLC |
50,000 |
636,000 |
0.66% |
|
|
| 20 |
NORTHERN TRUST CORP |
47,029 |
599,000 |
0.62% |
|
|
| 21 |
BlackRock Institutional Trust Company, N.A. |
33,862 |
431,000 |
0.45% |
|
|
| 22 |
OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) |
33,112 |
421,000 |
0.44% |
|
|
| 23 |
STATE STREET CORP |
30,087 |
383,000 |
0.40% |
|
|
| 24 |
BlackRock Group LTD |
29,386 |
374,000 |
0.39% |
|
|
| 25 |
CITADEL ADVISORS LLC |
24,391 |
310,000 |
0.32% |
|
|
| 26 |
GEODE CAPITAL MANAGEMENT, LLC |
21,687 |
275,000 |
0.28% |
|
|
| 27 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
20,458 |
260,000 |
0.27% |
|
|
| 28 |
BlackRock Investment Management, LLC |
19,874 |
253,000 |
0.26% |
|
|
| 29 |
Nationwide Fund Advisors |
17,070 |
217,000 |
0.22% |
|
|
| 30 |
Bank of New York Mellon Corp |
14,517 |
184,000 |
0.19% |
|
|
| 31 |
BlackRock Finance, Inc. |
8,872 |
113,000 |
0.12% |
|
|
| 32 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
8,798 |
112,000 |
0.12% |
|
|
| 33 |
SEI INVESTMENTS CO |
8,214 |
104,000 |
0.11% |
|
|
| 34 |
TEACHERS ADVISORS, LLC |
6,929 |
88,000 |
0.09% |
|
|
| 35 |
NEW YORK STATE COMMON RETIREMENT FUND |
4,400 |
56,000 |
0.06% |
|
|
| 36 |
AMERICAN INTERNATIONAL GROUP, INC. |
2,825 |
36,000 |
0.04% |
|
|
| 37 |
MORGAN STANLEY |
2,637 |
33,000 |
0.03% |
|
|
| 38 |
STRS OHIO |
1,500 |
19,000 |
0.02% |
|
|
| 39 |
DEUTSCHE BANK AG\ |
1,326 |
16,000 |
0.02% |
|
|
| 40 |
BNP PARIBAS FINANCIAL MARKETS |
995 |
12,656 |
0.01% |
|
|
| 41 |
UBS Group AG |
978 |
12,000 |
0.01% |
|
|
| 42 |
Stevens First Principles Investment Advisors |
800 |
10,000 |
0.01% |
|
|
| 43 |
ROYAL BANK OF CANADA |
294 |
4,000 |
0.00% |
|
|
| 44 |
Tower Research Capital LLC (TRC) |
274 |
3,000 |
0.00% |
|
|
| 45 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
85 |
1,000 |
0.00% |
|
|
| 46 |
BARCLAYS PLC |
25 |
0 |
0.00% |
|
|
| 47 |
WELLS FARGO & COMPANY/MN |
22 |
0 |
0.00% |
|
|
| 48 |
BANK OF AMERICA CORP /DE/ |
16 |
0 |
0.00% |
|
|
