| 1 |
FMR LLC |
2,021,217 |
28,337,000 |
34.04% |
|
|
| 2 |
RA CAPITAL MANAGEMENT, L.P. |
1,141,333 |
16,001,000 |
19.22% |
|
|
| 3 |
GOLDMAN SACHS GROUP INC |
327,124 |
4,586,000 |
5.51% |
|
|
| 4 |
PERCEPTIVE ADVISORS LLC |
300,000 |
4,206,000 |
5.05% |
|
|
| 5 |
SABBY MANAGEMENT, LLC |
294,982 |
4,136,000 |
4.97% |
|
|
| 6 |
Rock Springs Capital Management LP |
250,000 |
3,505,000 |
4.21% |
|
|
| 7 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
237,583 |
3,331,000 |
4.00% |
|
|
| 8 |
Broadfin Capital, LLC |
150,000 |
2,103,000 |
2.53% |
|
|
| 9 |
ACUTA CAPITAL PARTNERS, LLC |
130,000 |
1,823,000 |
2.19% |
|
|
| 10 |
BlackRock Fund Advisors |
128,143 |
1,797,000 |
2.16% |
|
|
| 11 |
EVENTIDE ASSET MANAGEMENT, LLC |
122,628 |
1,719,000 |
2.06% |
|
|
| 12 |
MILLENNIUM MANAGEMENT LLC |
117,409 |
1,646,000 |
1.98% |
|
|
| 13 |
Alyeska Investment Group, L.P. |
111,811 |
1,568,000 |
1.88% |
|
|
| 14 |
PUTNAM INVESTMENTS LLC |
100,000 |
1,402,000 |
1.68% |
|
|
| 15 |
VANGUARD GROUP INC |
86,246 |
1,210,000 |
1.45% |
|
|
| 16 |
BLACKROCK ADVISORS LLC |
51,269 |
719,000 |
0.86% |
|
|
| 17 |
AWM Investment Company, Inc. |
50,075 |
702,000 |
0.84% |
|
|
| 18 |
Tekla Capital Management LLC |
50,000 |
701,000 |
0.84% |
|
|
| 19 |
OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) |
33,112 |
464,000 |
0.56% |
|
|
| 20 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
32,959 |
462,000 |
0.55% |
|
|
| 21 |
BlackRock Group LTD |
29,386 |
412,000 |
0.49% |
|
|
| 22 |
BlackRock Institutional Trust Company, N.A. |
29,370 |
412,000 |
0.49% |
|
|
| 23 |
CITADEL ADVISORS LLC |
23,207 |
325,000 |
0.39% |
|
|
| 24 |
STATE STREET CORP |
22,721 |
318,000 |
0.38% |
|
|
| 25 |
BlackRock Investment Management, LLC |
20,176 |
283,000 |
0.34% |
|
|
| 26 |
Bank of New York Mellon Corp |
12,200 |
171,000 |
0.21% |
|
|
| 27 |
Nationwide Fund Advisors |
10,070 |
141,000 |
0.17% |
|
|
| 28 |
NORGES BANK |
10,000 |
140,000 |
0.17% |
|
|
| 29 |
BlackRock Finance, Inc. |
8,872 |
124,000 |
0.15% |
|
|
| 30 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
8,798 |
123,000 |
0.15% |
|
|
| 31 |
BANK OF MONTREAL /CAN/ |
8,000 |
112,000 |
0.13% |
|
|
| 32 |
TEACHERS ADVISORS, LLC |
6,929 |
97,000 |
0.12% |
|
|
| 33 |
AMERICAN INTERNATIONAL GROUP, INC. |
2,822 |
39,564 |
0.05% |
|
|
| 34 |
MORGAN STANLEY |
2,703 |
38,000 |
0.05% |
|
|
| 35 |
NEW YORK STATE COMMON RETIREMENT FUND |
2,540 |
36,000 |
0.04% |
|
|
| 36 |
STRS OHIO |
1,500 |
21,000 |
0.03% |
|
|
| 37 |
DEUTSCHE BANK AG\ |
1,157 |
16,000 |
0.02% |
|
|
| 38 |
ROYAL BANK OF CANADA |
329 |
5,000 |
0.01% |
|
|
| 39 |
Invesco Ltd. |
366 |
5,000 |
0.01% |
|
|
| 40 |
WELLS FARGO & COMPANY/MN |
241 |
3,000 |
0.00% |
|
|
| 41 |
CITIGROUP INC |
125 |
2,000 |
0.00% |
|
|
| 42 |
BANK OF AMERICA CORP /DE/ |
132 |
2,000 |
0.00% |
|
|
| 43 |
BARCLAYS PLC |
92 |
1,000 |
0.00% |
|
|
| 44 |
Tower Research Capital LLC (TRC) |
59 |
1,000 |
0.00% |
|
|
| 45 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
85 |
1,000 |
0.00% |
|
|
| 46 |
UBS Group AG |
19 |
0 |
0.00% |
|
|
