| 1 |
FMR LLC |
1,724,850 |
21,906,000 |
19.56% |
|
|
| 2 |
FRAZIER MANAGEMENT LLC |
1,312,258 |
16,666,000 |
14.88% |
|
|
| 3 |
RA CAPITAL MANAGEMENT, L.P. |
1,174,219 |
14,913,000 |
13.32% |
|
|
| 4 |
Aisling Capital LLC |
1,019,455 |
12,947,000 |
11.56% |
|
|
| 5 |
BB BIOTECH AG |
746,824 |
9,485,000 |
8.47% |
|
|
| 6 |
PERCEPTIVE ADVISORS LLC |
742,858 |
9,434,000 |
8.42% |
|
|
| 7 |
GOLDMAN SACHS GROUP INC |
274,629 |
3,488,000 |
3.11% |
|
|
| 8 |
AWM Investment Company, Inc. |
265,000 |
3,365,000 |
3.00% |
|
|
| 9 |
EVENTIDE ASSET MANAGEMENT, LLC |
264,000 |
3,353,000 |
2.99% |
|
|
| 10 |
Rock Springs Capital Management LP |
250,000 |
3,175,000 |
2.84% |
|
|
| 11 |
Broadfin Capital, LLC |
166,875 |
2,119,000 |
1.89% |
|
|
| 12 |
VANGUARD GROUP INC |
162,252 |
2,061,000 |
1.84% |
|
|
| 13 |
BlackRock Fund Advisors |
123,125 |
1,564,000 |
1.40% |
|
|
| 14 |
PUTNAM INVESTMENTS LLC |
100,000 |
1,270,000 |
1.13% |
|
|
| 15 |
Tekla Capital Management LLC |
72,500 |
921,000 |
0.82% |
|
|
| 16 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
68,779 |
873,000 |
0.78% |
|
|
| 17 |
NORTHERN TRUST CORP |
50,217 |
638,000 |
0.57% |
|
|
| 18 |
SABBY MANAGEMENT, LLC |
40,277 |
512,000 |
0.46% |
|
|
| 19 |
STATE STREET CORP |
37,477 |
475,000 |
0.42% |
|
|
| 20 |
BlackRock Institutional Trust Company, N.A. |
34,429 |
437,000 |
0.39% |
|
|
| 21 |
GEODE CAPITAL MANAGEMENT, LLC |
27,025 |
343,000 |
0.31% |
|
|
| 22 |
OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) |
20,000 |
254,000 |
0.23% |
|
|
| 23 |
BlackRock Investment Management, LLC |
17,272 |
219,000 |
0.20% |
|
|
| 24 |
Nationwide Fund Advisors |
17,070 |
217,000 |
0.19% |
|
|
| 25 |
Bank of New York Mellon Corp |
16,414 |
208,000 |
0.19% |
|
|
| 26 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
15,388 |
195,000 |
0.17% |
|
|
| 27 |
CAXTON CORP |
12,812 |
163,000 |
0.15% |
|
|
| 28 |
Spark Investment Management LLC |
11,600 |
147,000 |
0.13% |
|
|
| 29 |
A.R.T. Advisors, LLC |
11,325 |
143,000 |
0.13% |
|
|
| 30 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
10,266 |
130,000 |
0.12% |
|
|
| 31 |
TEACHERS ADVISORS, LLC |
6,929 |
88,000 |
0.08% |
|
|
| 32 |
CITIGROUP INC |
5,213 |
67,000 |
0.06% |
|
|
| 33 |
NEW YORK STATE COMMON RETIREMENT FUND |
4,400 |
56,000 |
0.05% |
|
|
| 34 |
AMERICAN INTERNATIONAL GROUP, INC. |
2,820 |
36,000 |
0.03% |
|
|
| 35 |
BLACKROCK ADVISORS LLC |
2,380 |
30,000 |
0.03% |
|
|
| 36 |
MORGAN STANLEY |
2,048 |
25,000 |
0.02% |
|
|
| 37 |
STRS OHIO |
1,500 |
19,000 |
0.02% |
|
|
| 38 |
BlackRock Japan Co. Ltd |
1,249 |
16,000 |
0.01% |
|
|
| 39 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
1,275 |
14,000 |
0.01% |
|
|
| 40 |
DEUTSCHE BANK AG\ |
721 |
9,000 |
0.01% |
|
|
| 41 |
WELLS FARGO & COMPANY/MN |
360 |
4,000 |
0.00% |
|
|
| 42 |
JPMORGAN CHASE & CO |
111 |
1,000 |
0.00% |
|
|
| 43 |
BANK OF MONTREAL /CAN/ |
97 |
1,000 |
0.00% |
|
|
| 44 |
BlackRock Finance, Inc. |
79 |
1,000 |
0.00% |
|
|
| 45 |
Tower Research Capital LLC (TRC) |
50 |
1,000 |
0.00% |
|
|
