| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | NEA Management Company, LLC | 9,880,999 | 80,333,000 | 30.99% | ||
| 2 | FMR LLC | 7,078,480 | 57,549,000 | 22.20% | ||
| 3 | Capital World Investors | 4,601,000 | 37,406,000 | 14.43% | ||
| 4 | Foresite Capital Management II, LLC | 1,761,567 | 14,322,000 | 5.53% | ||
| 5 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,150,000 | 9,350,000 | 3.61% | ||
| 6 | MILLENNIUM MANAGEMENT LLC | 916,622 | 7,452,000 | 2.87% | ||
| 7 | QVT Financial LP | 783,645 | 6,371,000 | 2.46% | ||
| 8 | Rock Springs Capital Management LP | 765,001 | 6,219,000 | 2.40% | ||
| 9 | FIL Ltd | 753,740 | 6,128,000 | 2.36% | ||
| 10 | WELLINGTON MANAGEMENT GROUP LLP | 533,643 | 4,339,000 | 1.67% | ||
| 11 | ORBIMED ADVISORS LLC | 438,784 | 3,567,000 | 1.38% | ||
| 12 | BAILLIE GIFFORD & CO | 429,700 | 3,493,000 | 1.35% | ||
| 13 | JENNISON ASSOCIATES LLC | 402,967 | 3,276,000 | 1.26% | ||
| 14 | Tekla Capital Management LLC | 296,934 | 2,414,000 | 0.93% | ||
| 15 | Iguana Healthcare Management, LLC | 250,000 | 2,033,000 | 0.78% | ||
| 16 | Abingworth LLP | 250,000 | 2,028,000 | 0.78% | ||
| 17 | Rathbones Group PLC | 200,525 | 1,630,000 | 0.63% | ||
| 18 | Opaleye Management Inc. | 175,300 | 1,425,000 | 0.55% | ||
| 19 | RENAISSANCE TECHNOLOGIES LLC | 113,200 | 920,000 | 0.35% | ||
| 20 | Weiss Multi-Strategy Advisers LLC | 110,000 | 894,000 | 0.34% | ||
| 21 | Zurcher Kantonalbank (Zurich Cantonalbank) | 105,476 | 858,000 | 0.33% | ||
| 22 | BAKER BROS. ADVISORS LP | 100,000 | 813,000 | 0.31% | ||
| 23 | DAFNA Capital Management LLC | 88,100 | 716,000 | 0.28% | ||
| 24 | STATE STREET CORP | 65,800 | 535,000 | 0.21% | ||
| 25 | RS INVESTMENT MANAGEMENT CO LLC | 62,980 | 512,000 | 0.20% | ||
| 26 | ESSEX INVESTMENT MANAGEMENT CO LLC | 60,575 | 492,000 | 0.19% | ||
| 27 | Compagnie Lombard Odier SCmA | 57,560 | 468,000 | 0.18% | ||
| 28 | PUTNAM INVESTMENTS LLC | 51,481 | 419,000 | 0.16% | ||
| 29 | Polar Capital LLP | 50,000 | 407,000 | 0.16% | ||
| 30 | Ghost Tree Capital, LLC | 50,000 | 407,000 | 0.16% | ||
| 31 | ASCEND CAPITAL, LLC | 50,000 | 406,000 | 0.16% | ||
| 32 | Creative Planning | 32,500 | 264,000 | 0.10% | ||
| 33 | VIRTUS ETF ADVISERS LLC | 28,182 | 229,000 | 0.09% | ||
| 34 | Cormorant Asset Management, LP | 25,000 | 203,000 | 0.08% | ||
| 35 | PRELUDE CAPITAL MANAGEMENT, LLC | 24,900 | 202,000 | 0.08% | ||
| 36 | State of New Jersey Common Pension Fund D | 24,000 | 195,000 | 0.08% | ||
| 37 | FRED ALGER MANAGEMENT, LLC | 23,045 | 187,000 | 0.07% | ||
| 38 | A.R.T. Advisors, LLC | 21,600 | 175,000 | 0.07% | ||
| 39 | NJ State Employees Deferred Compensation Plan | 16,000 | 151,000 | 0.06% | ||
| 40 | Vident Investment Advisory, LLC | 1,147,030 | 142,000 | 0.05% | ||
| 41 | D. E. Shaw & Co., Inc. | 11,832 | 96,000 | 0.04% | ||
| 42 | MORGAN STANLEY | 9,631 | 78,000 | 0.03% | ||
| 43 | RTW INVESTMENTS, LP | 7,691 | 63,000 | 0.02% | ||
| 44 | GLENMEDE TRUST CO NA | 3,100 | 25,000 | 0.01% | ||
| 45 | OGOREK ANTHONY JOSEPH /NY/ /ADV | 1,000 | 8,000 | 0.00% | ||
| 46 | D.A. DAVIDSON & CO. | 1,000 | 8,000 | 0.00% | ||
| 47 | WELLS FARGO & COMPANY/MN | 800 | 7,000 | 0.00% | ||
| 48 | BANK OF AMERICA CORP /DE/ | 353 | 3,000 | 0.00% | ||
| 49 | CITIGROUP INC | 1 | 0 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
