| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 865 | 3,000 | 0.01% | ||
| 2 | BlackRock Investment Management, LLC | 1,024 | 4,000 | 0.01% | ||
| 3 | Creative Planning | 1,000 | 4,000 | 0.01% | ||
| 4 | Tower Research Capital LLC (TRC) | 1,443 | 5,000 | 0.01% | ||
| 5 | CITIGROUP INC | 2,621 | 9,000 | 0.02% | ||
| 6 | MORGAN STANLEY | 9,499 | 35,000 | 0.08% | ||
| 7 | GOLDMAN SACHS GROUP INC | 12,711 | 46,000 | 0.11% | ||
| 8 | FT OPTIONS LLC | 17,736 | 64,000 | 0.15% | ||
| 9 | BlackRock Fund Advisors | 18,108 | 65,000 | 0.15% | ||
| 10 | GILDER GAGNON HOWE & CO LLC | 22,445 | 81,000 | 0.19% | ||
| 11 | GEODE CAPITAL MANAGEMENT, LLC | 33,211 | 119,000 | 0.28% | ||
| 12 | FRED ALGER MANAGEMENT, LLC | 44,282 | 160,000 | 0.38% | ||
| 13 | Rhenman & Partners Asset Management AB | 100,000 | 361,000 | 0.86% | ||
| 14 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 101,347 | 366,000 | 0.87% | ||
| 15 | FEDERATED HERMES, INC. | 160,000 | 578,000 | 1.37% | ||
| 16 | Alyeska Investment Group, L.P. | 223,885 | 808,000 | 1.92% | ||
| 17 | VANGUARD GROUP INC | 224,325 | 810,000 | 1.92% | ||
| 18 | WELLINGTON MANAGEMENT GROUP LLP | 281,327 | 1,016,000 | 2.41% | ||
| 19 | SPHERA FUNDS MANAGEMENT LTD. | 387,943 | 1,400,000 | 3.32% | ||
| 20 | GREAT POINT PARTNERS LLC | 556,537 | 2,009,000 | 4.77% | ||
| 21 | DEERFIELD MANAGEMENT COMPANY, L.P. | 682,940 | 2,465,000 | 5.85% | ||
| 22 | Cormorant Asset Management, LP | 800,000 | 2,888,000 | 6.85% | ||
| 23 | Camber Capital Management LP | 1,000,000 | 3,610,000 | 8.57% | ||
| 24 | FMR LLC | 1,377,298 | 4,972,000 | 11.80% | ||
| 25 | Clarus Ventures, LLC | 2,752,488 | 9,937,000 | 23.59% | ||
| 26 | SV Health Investors, LLC | 2,857,667 | 10,315,000 | 24.48% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
