| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Capital Research Global Investors | 20,216,215 | 1,870,404,000 | 11.88% | ||
| 2 | VANGUARD GROUP INC | 12,230,286 | 1,131,547,000 | 7.19% | ||
| 3 | SANDS CAPITAL MANAGEMENT, LLC | 10,221,282 | 945,673,000 | 6.01% | ||
| 4 | FMR LLC | 10,079,541 | 932,559,000 | 5.92% | ||
| 5 | JENNISON ASSOCIATES LLC | 9,702,200 | 897,648,000 | 5.70% | ||
| 6 | PRIMECAP MANAGEMENT CO/CA/ | 7,108,129 | 657,644,000 | 4.18% | ||
| 7 | BAKER BROS. ADVISORS LP | 4,806,483 | 444,696,000 | 2.82% | ||
| 8 | BlackRock Institutional Trust Company, N.A. | 4,131,259 | 382,224,000 | 2.43% | ||
| 9 | BlackRock Fund Advisors | 4,049,472 | 374,657,000 | 2.38% | ||
| 10 | JPMORGAN CHASE & CO | 3,701,061 | 342,548,000 | 2.18% | ||
| 11 | STATE STREET CORP | 3,620,028 | 334,931,000 | 2.13% | ||
| 12 | Temasek Holdings (Private) Ltd | 3,472,712 | 321,295,000 | 2.04% | ||
| 13 | Invesco Ltd. | 3,059,368 | 283,054,000 | 1.80% | ||
| 14 | PRICE T ROWE ASSOCIATES INC /MD/ | 2,587,129 | 239,361,000 | 1.52% | ||
| 15 | WELLS FARGO & COMPANY/MN | 2,381,816 | 220,366,000 | 1.40% | ||
| 16 | OppenheimerFunds, Inc. | 2,164,153 | 200,228,000 | 1.27% | ||
| 17 | Bank of New York Mellon Corp | 2,092,523 | 193,600,000 | 1.23% | ||
| 18 | Palo Alto Investors LP | 1,790,899 | 165,694,000 | 1.05% | ||
| 19 | BANK OF AMERICA CORP /DE/ | 1,649,287 | 152,593,000 | 0.97% | ||
| 20 | FRANKLIN RESOURCES INC | 1,646,896 | 152,374,000 | 0.97% | ||
| 21 | FRED ALGER MANAGEMENT, LLC | 1,644,829 | 152,180,000 | 0.97% | ||
| 22 | DEUTSCHE BANK AG\ | 1,550,912 | 143,484,000 | 0.91% | ||
| 23 | AMERIPRISE FINANCIAL INC | 1,511,704 | 139,857,000 | 0.89% | ||
| 24 | TIAA CREF INVESTMENT MANAGEMENT LLC | 1,387,191 | 128,343,000 | 0.82% | ||
| 25 | GOLDMAN SACHS GROUP INC | 1,331,800 | 123,218,000 | 0.78% | ||
| 26 | NORTHERN TRUST CORP | 1,294,318 | 119,750,000 | 0.76% | ||
| 27 | VICTORY CAPITAL MANAGEMENT INC | 1,268,066 | 117,321,000 | 0.75% | ||
| 28 | WADDELL & REED FINANCIAL INC | 1,177,946 | 108,983,000 | 0.69% | ||
| 29 | WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 1,176,075 | 108,810,000 | 0.69% | ||
| 30 | ORBIMED ADVISORS LLC | 1,151,900 | 106,574,000 | 0.68% | ||
| 31 | TCW GROUP INC | 1,149,018 | 106,308,000 | 0.68% | ||
| 32 | GEODE CAPITAL MANAGEMENT, LLC | 1,138,621 | 105,303,000 | 0.67% | ||
| 33 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,081,092 | 100,024,000 | 0.64% | ||
| 34 | BlackRock Group LTD | 1,040,015 | 96,221,000 | 0.61% | ||
| 35 | CITADEL ADVISORS LLC | 973,285 | 90,048,000 | 0.57% | ||
| 36 | NORGES BANK | 987,380 | 87,251,000 | 0.55% | ||
| 37 | PICTET ASSET MANAGEMENT LTD | 894,843 | 82,791,000 | 0.53% | ||
| 38 | Senator Investment Group LP | 850,000 | 78,642,000 | 0.50% | ||
| 39 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 815,068 | 75,410,000 | 0.48% | ||
| 40 | Alyeska Investment Group, L.P. | 808,248 | 74,779,000 | 0.47% | ||
| 41 | Blue Ridge Capital, L.L.C. | 800,000 | 74,016,000 | 0.47% | ||
| 42 | Clearbridge Investments, LLC | 725,445 | 67,118,000 | 0.43% | ||
| 43 | PFM Health Sciences, LP | 722,738 | 66,868,000 | 0.42% | ||
| 44 | Tekla Capital Management LLC | 710,145 | 65,703,000 | 0.42% | ||
| 45 | FRONTIER CAPITAL MANAGEMENT CO LLC | 700,388 | 64,800,000 | 0.41% | ||
| 46 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 645,500 | 59,722,000 | 0.38% | Put | |
| 47 | Legal & General Group Plc | 644,337 | 59,614,000 | 0.38% | ||
| 48 | Allianz Asset Management GmbH | 633,614 | 58,689,000 | 0.37% | ||
| 49 | PUTNAM INVESTMENTS LLC | 625,121 | 57,836,000 | 0.37% | ||
| 50 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 625,000 | 57,825,000 | 0.37% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
