| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 6,087,235 | 154,129,000 | 27.98% | ||
| 2 | Foresite Capital Management II, LLC | 4,087,900 | 103,506,000 | 18.79% | ||
| 3 | Aisling Capital LLC | 2,820,000 | 71,402,000 | 12.96% | ||
| 4 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,241,400 | 31,423,000 | 5.70% | ||
| 5 | PFM Health Sciences, LP | 996,112 | 25,222,000 | 4.58% | ||
| 6 | SECTORAL ASSET MANAGEMENT INC | 792,638 | 20,070,000 | 3.64% | ||
| 7 | RA CAPITAL MANAGEMENT, L.P. | 790,200 | 20,008,000 | 3.63% | ||
| 8 | RS INVESTMENT MANAGEMENT CO LLC | 715,963 | 18,128,000 | 3.29% | ||
| 9 | ALLIANCEBERNSTEIN L.P. | 606,029 | 15,345,000 | 2.79% | ||
| 10 | VANGUARD GROUP INC | 562,924 | 14,254,000 | 2.59% | ||
| 11 | PRICE T ROWE ASSOCIATES INC /MD/ | 441,638 | 11,182,000 | 2.03% | ||
| 12 | Palo Alto Investors LP | 325,599 | 8,244,000 | 1.50% | ||
| 13 | BlackRock Fund Advisors | 265,713 | 6,728,000 | 1.22% | ||
| 14 | BAKER BROS. ADVISORS LP | 250,000 | 6,330,000 | 1.15% | ||
| 15 | JENNISON ASSOCIATES LLC | 200,503 | 5,077,000 | 0.92% | ||
| 16 | Rock Springs Capital Management LP | 200,000 | 5,064,000 | 0.92% | ||
| 17 | FRED ALGER MANAGEMENT, LLC | 148,299 | 3,755,000 | 0.68% | ||
| 18 | STATE STREET CORP | 121,537 | 3,077,000 | 0.56% | ||
| 19 | BlackRock Institutional Trust Company, N.A. | 103,915 | 2,631,000 | 0.48% | ||
| 20 | AMERICAN CENTURY COMPANIES INC | 82,292 | 2,084,000 | 0.38% | ||
| 21 | PICTET ASSET MANAGEMENT LTD | 76,600 | 1,940,000 | 0.35% | ||
| 22 | FRANKLIN RESOURCES INC | 68,413 | 1,732,000 | 0.31% | ||
| 23 | GEODE CAPITAL MANAGEMENT, LLC | 66,746 | 1,690,000 | 0.31% | ||
| 24 | CREDIT SUISSE AG/ | 65,924 | 1,669,000 | 0.30% | ||
| 25 | DRIEHAUS CAPITAL MANAGEMENT LLC | 64,315 | 1,628,000 | 0.30% | ||
| 26 | Alyeska Investment Group, L.P. | 50,000 | 1,266,000 | 0.23% | ||
| 27 | FEDERATED HERMES, INC. | 50,000 | 1,266,000 | 0.23% | ||
| 28 | LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 47,700 | 1,208,000 | 0.22% | ||
| 29 | MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 41,900 | 1,061,000 | 0.19% | ||
| 30 | EMERALD ADVISERS, LLC | 41,140 | 1,042,000 | 0.19% | ||
| 31 | EMERALD MUTUAL FUND ADVISERS TRUST | 40,280 | 1,020,000 | 0.19% | ||
| 32 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 38,373 | 972,000 | 0.18% | ||
| 33 | BlackRock Investment Management, LLC | 37,101 | 939,000 | 0.17% | ||
| 34 | TIAA CREF INVESTMENT MANAGEMENT LLC | 33,579 | 850,000 | 0.15% | ||
| 35 | NORTHERN TRUST CORP | 31,958 | 809,000 | 0.15% | ||
| 36 | Bank of New York Mellon Corp | 26,343 | 667,000 | 0.12% | ||
| 37 | Partner Investment Management, L.P. | 22,796 | 577,000 | 0.10% | ||
| 38 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 20,300 | 514,000 | 0.09% | ||
| 39 | GOLDMAN SACHS GROUP INC | 15,482 | 392,000 | 0.07% | ||
| 40 | TEACHERS ADVISORS, LLC | 11,294 | 286,000 | 0.05% | ||
| 41 | Geduld E E | 10,200 | 258,000 | 0.05% | ||
| 42 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 10,072 | 256,000 | 0.05% | ||
| 43 | JANE STREET GROUP, LLC | 9,943 | 252,000 | 0.05% | ||
| 44 | BANK OF AMERICA CORP /DE/ | 8,619 | 218,000 | 0.04% | ||
| 45 | BLACKROCK ADVISORS LLC | 5,292 | 134,000 | 0.02% | ||
| 46 | Tower Research Capital LLC (TRC) | 3,964 | 100,000 | 0.02% | ||
| 47 | STRS OHIO | 3,600 | 91,000 | 0.02% | ||
| 48 | DEUTSCHE BANK AG\ | 3,074 | 77,000 | 0.01% | ||
| 49 | WELLS FARGO & COMPANY/MN | 2,839 | 71,000 | 0.01% | ||
| 50 | Nationwide Fund Advisors | 2,730 | 69,000 | 0.01% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
