| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 6,337,414 | 116,925,000 | 24.35% | ||
| 2 | Foresite Capital Management II, LLC | 4,087,900 | 75,422,000 | 15.71% | ||
| 3 | Aisling Capital LLC | 2,990,000 | 55,166,000 | 11.49% | ||
| 4 | TLP GROUP LLC | 2,781,259 | 51,314,000 | 10.69% | ||
| 5 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,141,400 | 21,059,000 | 4.39% | ||
| 6 | SECTORAL ASSET MANAGEMENT INC | 982,133 | 18,120,000 | 3.77% | ||
| 7 | ALLIANCEBERNSTEIN L.P. | 675,050 | 17,092,000 | 3.56% | ||
| 8 | EAGLE ASSET MANAGEMENT INC | 856,082 | 15,794,000 | 3.29% | ||
| 9 | RS INVESTMENT MANAGEMENT CO LLC | 804,143 | 14,836,000 | 3.09% | ||
| 10 | RA CAPITAL MANAGEMENT, L.P. | 790,200 | 14,579,000 | 3.04% | ||
| 11 | VANGUARD GROUP INC | 696,808 | 12,856,000 | 2.68% | ||
| 12 | PRICE T ROWE ASSOCIATES INC /MD/ | 490,448 | 9,049,000 | 1.88% | ||
| 13 | FORESITE CAPITAL MANAGEMENT III, LLC | 355,020 | 6,550,000 | 1.36% | ||
| 14 | Palo Alto Investors LP | 325,599 | 6,007,000 | 1.25% | ||
| 15 | EMERALD MUTUAL FUND ADVISERS TRUST | 282,355 | 5,209,000 | 1.08% | ||
| 16 | BlackRock Fund Advisors | 280,954 | 5,184,000 | 1.08% | ||
| 17 | EMERALD ADVISERS, LLC | 270,358 | 4,988,000 | 1.04% | ||
| 18 | Rock Springs Capital Management LP | 259,646 | 4,790,000 | 1.00% | ||
| 19 | BAKER BROS. ADVISORS LP | 250,000 | 4,613,000 | 0.96% | ||
| 20 | STATE STREET CORP | 145,748 | 2,690,000 | 0.56% | ||
| 21 | BlackRock Institutional Trust Company, N.A. | 119,295 | 2,201,000 | 0.46% | ||
| 22 | NORTHERN TRUST CORP | 118,168 | 2,180,000 | 0.45% | ||
| 23 | PICTET ASSET MANAGEMENT LTD | 92,500 | 1,707,000 | 0.36% | ||
| 24 | AMERICAN CENTURY COMPANIES INC | 90,205 | 1,664,000 | 0.35% | ||
| 25 | GEODE CAPITAL MANAGEMENT, LLC | 72,471 | 1,337,000 | 0.28% | ||
| 26 | ALPS ADVISORS INC | 55,657 | 1,027,000 | 0.21% | ||
| 27 | TIAA CREF INVESTMENT MANAGEMENT LLC | 50,789 | 937,000 | 0.20% | ||
| 28 | FEDERATED HERMES, INC. | 50,000 | 923,000 | 0.19% | ||
| 29 | Bank of New York Mellon Corp | 44,549 | 822,000 | 0.17% | ||
| 30 | BlackRock Investment Management, LLC | 37,590 | 694,000 | 0.14% | ||
| 31 | Numeric Investors LLC | 34,800 | 642,000 | 0.13% | ||
| 32 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 26,257 | 485,000 | 0.10% | ||
| 33 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 20,593 | 380,000 | 0.08% | ||
| 34 | FRED ALGER MANAGEMENT, LLC | 17,250 | 318,000 | 0.07% | ||
| 35 | TEACHERS ADVISORS, LLC | 16,771 | 309,000 | 0.06% | ||
| 36 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 16,277 | 300,000 | 0.06% | ||
| 37 | BANK OF AMERICA CORP /DE/ | 15,578 | 287,000 | 0.06% | ||
| 38 | TD ASSET MANAGEMENT INC | 14,300 | 264,000 | 0.05% | ||
| 39 | Swiss National Bank | 13,300 | 245,000 | 0.05% | ||
| 40 | NEW YORK STATE COMMON RETIREMENT FUND | 10,700 | 197,000 | 0.04% | ||
| 41 | METROPOLITAN LIFE INSURANCE CO/NY | 8,820 | 163,000 | 0.03% | ||
| 42 | Nationwide Fund Advisors | 7,434 | 137,000 | 0.03% | ||
| 43 | WELLS FARGO & COMPANY/MN | 6,707 | 124,000 | 0.03% | ||
| 44 | PANAGORA ASSET MANAGEMENT INC | 6,375 | 118,000 | 0.02% | ||
| 45 | MORGAN STANLEY | 4,827 | 89,000 | 0.02% | ||
| 46 | CITIGROUP INC | 4,823 | 89,000 | 0.02% | ||
| 47 | BLACKROCK ADVISORS LLC | 3,684 | 68,000 | 0.01% | ||
| 48 | STRS OHIO | 3,600 | 66,000 | 0.01% | ||
| 49 | DEUTSCHE BANK AG\ | 2,774 | 50,000 | 0.01% | ||
| 50 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 1,920 | 35,000 | 0.01% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
