| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 4,911,827 | 73,677,000 | 16.22% | ||
| 2 | Foresite Capital Management II, LLC | 3,967,900 | 59,519,000 | 13.10% | ||
| 3 | Aisling Capital LLC | 2,990,000 | 44,850,000 | 9.87% | ||
| 4 | TLP GROUP LLC | 2,904,185 | 43,563,000 | 9.59% | ||
| 5 | EAGLE ASSET MANAGEMENT INC | 2,136,090 | 32,041,000 | 7.05% | ||
| 6 | VANGUARD GROUP INC | 1,520,568 | 22,809,000 | 5.02% | ||
| 7 | RA CAPITAL MANAGEMENT, L.P. | 1,292,940 | 19,394,000 | 4.27% | ||
| 8 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,162,530 | 17,438,000 | 3.84% | ||
| 9 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,116,400 | 16,746,000 | 3.69% | ||
| 10 | FORESITE CAPITAL MANAGEMENT III, LLC | 935,020 | 14,025,000 | 3.09% | ||
| 11 | VIVO CAPITAL, LLC | 763,009 | 11,445,000 | 2.52% | ||
| 12 | ALLIANCEBERNSTEIN L.P. | 691,242 | 10,369,000 | 2.28% | ||
| 13 | BAKER BROS. ADVISORS LP | 673,908 | 10,109,000 | 2.23% | ||
| 14 | BlackRock Fund Advisors | 664,746 | 9,971,000 | 2.20% | ||
| 15 | EMERALD ADVISERS, LLC | 464,364 | 6,965,000 | 1.53% | ||
| 16 | EMERALD MUTUAL FUND ADVISERS TRUST | 418,214 | 6,273,000 | 1.38% | ||
| 17 | STATE STREET CORP | 382,875 | 5,752,000 | 1.27% | ||
| 18 | Palo Alto Investors LP | 379,727 | 5,696,000 | 1.25% | ||
| 19 | BlackRock Institutional Trust Company, N.A. | 309,722 | 4,646,000 | 1.02% | ||
| 20 | Rock Springs Capital Management LP | 293,000 | 4,395,000 | 0.97% | ||
| 21 | NORTHERN TRUST CORP | 279,649 | 4,195,000 | 0.92% | ||
| 22 | MORGAN STANLEY | 236,430 | 3,547,000 | 0.78% | ||
| 23 | GEODE CAPITAL MANAGEMENT, LLC | 190,721 | 2,860,000 | 0.63% | ||
| 24 | JPMORGAN CHASE & CO | 182,650 | 2,740,000 | 0.60% | ||
| 25 | BANK OF AMERICA CORP /DE/ | 136,447 | 2,046,000 | 0.45% | ||
| 26 | AMERICAN CENTURY COMPANIES INC | 102,033 | 1,530,000 | 0.34% | ||
| 27 | BlackRock Investment Management, LLC | 95,795 | 1,437,000 | 0.32% | ||
| 28 | Bank of New York Mellon Corp | 90,663 | 1,360,000 | 0.30% | ||
| 29 | TIAA CREF INVESTMENT MANAGEMENT LLC | 83,728 | 1,256,000 | 0.28% | ||
| 30 | DEUTSCHE BANK AG\ | 81,937 | 1,227,000 | 0.27% | ||
| 31 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 77,957 | 1,170,000 | 0.26% | ||
| 32 | COLUMBUS CIRCLE INVESTORS | 61,198 | 918,000 | 0.20% | ||
| 33 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 55,515 | 833,000 | 0.18% | ||
| 34 | WELLS FARGO & COMPANY/MN | 54,933 | 824,000 | 0.18% | ||
| 35 | ALPS ADVISORS INC | 53,867 | 808,000 | 0.18% | ||
| 36 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 48,546 | 728,000 | 0.16% | ||
| 37 | TEACHERS ADVISORS, LLC | 42,204 | 633,000 | 0.14% | ||
| 38 | VICTORY CAPITAL MANAGEMENT INC | 38,570 | 579,000 | 0.13% | ||
| 39 | J.P. Morgan Private Wealth Advisors LLC | 37,050 | 556,000 | 0.12% | ||
| 40 | Swiss National Bank | 31,474 | 472,000 | 0.10% | ||
| 41 | TD ASSET MANAGEMENT INC | 31,478 | 472,000 | 0.10% | ||
| 42 | NEW YORK STATE COMMON RETIREMENT FUND | 26,900 | 404,000 | 0.09% | ||
| 43 | RHUMBLINE ADVISERS | 25,607 | 384,000 | 0.08% | ||
| 44 | CREDIT SUISSE AG/ | 21,966 | 329,000 | 0.07% | ||
| 45 | METROPOLITAN LIFE INSURANCE CO/NY | 20,796 | 312,000 | 0.07% | ||
| 46 | VIRTUS ETF ADVISERS LLC | 19,501 | 293,000 | 0.06% | ||
| 47 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 19,136 | 287,000 | 0.06% | ||
| 48 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 17,394 | 261,000 | 0.06% | ||
| 49 | RAYMOND JAMES & ASSOCIATES | 17,134 | 257,000 | 0.06% | ||
| 50 | CITADEL ADVISORS LLC | 16,944 | 254,000 | 0.06% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
