| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 4,949,027 | 101,207,000 | 14.94% | ||
| 2 | Foresite Capital Management II, LLC | 3,835,830 | 78,443,000 | 11.58% | ||
| 3 | Aisling Capital LLC | 2,990,000 | 61,146,000 | 9.03% | ||
| 4 | TLP GROUP LLC | 2,467,976 | 50,470,000 | 7.45% | ||
| 5 | EAGLE ASSET MANAGEMENT INC | 2,147,151 | 43,909,000 | 6.48% | ||
| 6 | VANGUARD GROUP INC | 1,686,055 | 34,479,000 | 5.09% | ||
| 7 | BlackRock Fund Advisors | 1,360,818 | 27,829,000 | 4.11% | ||
| 8 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,141,400 | 23,342,000 | 3.45% | ||
| 9 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,086,151 | 22,212,000 | 3.28% | ||
| 10 | FORESITE CAPITAL MANAGEMENT III, LLC | 903,890 | 18,485,000 | 2.73% | ||
| 11 | EMERALD ADVISERS, LLC | 772,995 | 15,808,000 | 2.33% | ||
| 12 | VIVO CAPITAL, LLC | 763,009 | 15,604,000 | 2.30% | ||
| 13 | ALLIANCEBERNSTEIN L.P. | 715,727 | 14,637,000 | 2.16% | ||
| 14 | RA CAPITAL MANAGEMENT, L.P. | 677,663 | 13,858,000 | 2.05% | ||
| 15 | BAKER BROS. ADVISORS LP | 673,908 | 13,781,000 | 2.03% | ||
| 16 | BlackRock Institutional Trust Company, N.A. | 638,472 | 13,057,000 | 1.93% | ||
| 17 | EMERALD MUTUAL FUND ADVISERS TRUST | 607,256 | 12,418,000 | 1.83% | ||
| 18 | STATE STREET CORP | 576,147 | 11,782,000 | 1.74% | ||
| 19 | Point72 Asset Management, L.P. | 407,700 | 8,337,000 | 1.23% | ||
| 20 | Palo Alto Investors LP | 379,727 | 7,765,000 | 1.15% | ||
| 21 | MORGAN STANLEY | 328,611 | 6,720,000 | 0.99% | ||
| 22 | WELLINGTON MANAGEMENT GROUP LLP | 312,530 | 6,391,000 | 0.94% | ||
| 23 | JPMORGAN CHASE & CO | 296,187 | 6,057,000 | 0.89% | ||
| 24 | Rock Springs Capital Management LP | 293,000 | 5,992,000 | 0.88% | ||
| 25 | NORTHERN TRUST CORP | 288,373 | 5,898,000 | 0.87% | ||
| 26 | GEODE CAPITAL MANAGEMENT, LLC | 196,749 | 4,023,000 | 0.59% | ||
| 27 | Employees Retirement System of Texas | 194,804 | 3,984,000 | 0.59% | ||
| 28 | Informed Momentum Co LLC | 165,625 | 3,387,000 | 0.50% | ||
| 29 | BANK OF AMERICA CORP /DE/ | 144,507 | 2,955,000 | 0.44% | ||
| 30 | Bank of New York Mellon Corp | 136,238 | 2,786,000 | 0.41% | ||
| 31 | AMERICAN CENTURY COMPANIES INC | 108,692 | 2,223,000 | 0.33% | ||
| 32 | DEUTSCHE BANK AG\ | 104,283 | 2,131,000 | 0.31% | ||
| 33 | RENAISSANCE TECHNOLOGIES LLC | 102,700 | 2,100,000 | 0.31% | ||
| 34 | PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO | 97,403 | 1,992,000 | 0.29% | ||
| 35 | BlackRock Investment Management, LLC | 95,666 | 1,956,000 | 0.29% | ||
| 36 | RUSSELL INVESTMENTS GROUP, LTD. | 83,336 | 1,711,000 | 0.25% | ||
| 37 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 82,269 | 1,683,000 | 0.25% | ||
| 38 | Artal Group S.A. | 81,600 | 1,669,000 | 0.25% | ||
| 39 | TIAA CREF INVESTMENT MANAGEMENT LLC | 79,218 | 1,620,000 | 0.24% | ||
| 40 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 73,279 | 1,499,000 | 0.22% | ||
| 41 | WELLS FARGO & COMPANY/MN | 63,688 | 1,302,000 | 0.19% | ||
| 42 | NORGES BANK | 61,500 | 1,258,000 | 0.19% | ||
| 43 | AMERIPRISE FINANCIAL INC | 55,773 | 1,141,000 | 0.17% | ||
| 44 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 54,215 | 1,109,000 | 0.16% | ||
| 45 | CITIGROUP INC | 49,307 | 1,008,000 | 0.15% | ||
| 46 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 45,094 | 922,000 | 0.14% | ||
| 47 | TEACHERS ADVISORS, LLC | 43,229 | 884,000 | 0.13% | ||
| 48 | GOLDMAN SACHS GROUP INC | 42,216 | 863,000 | 0.13% | ||
| 49 | ALPS ADVISORS INC | 40,730 | 833,000 | 0.12% | ||
| 50 | PENN MUTUAL LIFE INSURANCE CO | 39,000 | 797,000 | 0.12% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
