| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 5,156,977 | 69,928,000 | 18.71% | ||
| 2 | Foresite Capital Management II, LLC | 4,087,900 | 55,432,000 | 14.83% | ||
| 3 | Aisling Capital LLC | 2,990,000 | 40,544,000 | 10.85% | ||
| 4 | TLP GROUP LLC | 2,816,285 | 38,189,000 | 10.22% | ||
| 5 | EAGLE ASSET MANAGEMENT INC | 1,760,995 | 23,879,000 | 6.39% | ||
| 6 | RA CAPITAL MANAGEMENT, L.P. | 1,292,940 | 17,532,000 | 4.69% | ||
| 7 | VANGUARD GROUP INC | 1,230,390 | 16,685,000 | 4.47% | ||
| 8 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,141,400 | 15,477,000 | 4.14% | ||
| 9 | SECTORAL ASSET MANAGEMENT INC | 982,133 | 13,318,000 | 3.56% | ||
| 10 | RS INVESTMENT MANAGEMENT CO LLC | 831,940 | 11,281,000 | 3.02% | ||
| 11 | ALLIANCEBERNSTEIN L.P. | 636,971 | 8,637,000 | 2.31% | ||
| 12 | EcoR1 Capital, LLC | 521,366 | 7,070,000 | 1.89% | ||
| 13 | PRICE T ROWE ASSOCIATES INC /MD/ | 488,398 | 6,623,000 | 1.77% | ||
| 14 | FORESITE CAPITAL MANAGEMENT III, LLC | 355,020 | 4,814,000 | 1.29% | ||
| 15 | EMERALD MUTUAL FUND ADVISERS TRUST | 328,655 | 4,457,000 | 1.19% | ||
| 16 | Palo Alto Investors LP | 325,599 | 4,415,000 | 1.18% | ||
| 17 | Rock Springs Capital Management LP | 293,000 | 3,973,000 | 1.06% | ||
| 18 | EMERALD ADVISERS, LLC | 270,060 | 3,662,000 | 0.98% | ||
| 19 | BlackRock Fund Advisors | 266,606 | 3,615,000 | 0.97% | ||
| 20 | BAKER BROS. ADVISORS LP | 250,000 | 3,390,000 | 0.91% | ||
| 21 | STATE STREET CORP | 158,344 | 2,146,000 | 0.57% | ||
| 22 | BANK OF AMERICA CORP /DE/ | 145,420 | 1,972,000 | 0.53% | ||
| 23 | NORTHERN TRUST CORP | 119,429 | 1,620,000 | 0.43% | ||
| 24 | BlackRock Institutional Trust Company, N.A. | 116,601 | 1,581,000 | 0.42% | ||
| 25 | PICTET ASSET MANAGEMENT LTD | 92,500 | 1,480,000 | 0.40% | ||
| 26 | AMERICAN CENTURY COMPANIES INC | 94,060 | 1,275,000 | 0.34% | ||
| 27 | GEODE CAPITAL MANAGEMENT, LLC | 92,923 | 1,260,000 | 0.34% | ||
| 28 | WELLS FARGO & COMPANY/MN | 54,692 | 741,000 | 0.20% | ||
| 29 | Bank of New York Mellon Corp | 51,416 | 697,000 | 0.19% | ||
| 30 | FEDERATED HERMES, INC. | 50,000 | 678,000 | 0.18% | ||
| 31 | ALPS ADVISORS INC | 47,514 | 644,000 | 0.17% | ||
| 32 | JPMORGAN CHASE & CO | 42,300 | 574,000 | 0.15% | ||
| 33 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 39,114 | 530,000 | 0.14% | ||
| 34 | BlackRock Investment Management, LLC | 38,578 | 523,000 | 0.14% | ||
| 35 | TIAA CREF INVESTMENT MANAGEMENT LLC | 33,579 | 455,000 | 0.12% | ||
| 36 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 26,716 | 363,000 | 0.10% | ||
| 37 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 23,560 | 319,000 | 0.09% | ||
| 38 | TFS CAPITAL LLC | 23,302 | 316,000 | 0.08% | ||
| 39 | MORGAN STANLEY | 22,639 | 307,000 | 0.08% | ||
| 40 | Swiss National Bank | 22,274 | 292,000 | 0.08% | ||
| 41 | CREDIT SUISSE AG/ | 18,775 | 255,000 | 0.07% | ||
| 42 | Dynamic Technology Lab Private Ltd | 16,873 | 229,000 | 0.06% | ||
| 43 | TEACHERS ADVISORS, LLC | 16,771 | 227,000 | 0.06% | ||
| 44 | GOLDMAN SACHS GROUP INC | 15,639 | 212,000 | 0.06% | ||
| 45 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 13,795 | 188,000 | 0.05% | ||
| 46 | VIRTUS ETF ADVISERS LLC | 13,666 | 185,000 | 0.05% | ||
| 47 | TD ASSET MANAGEMENT INC | 13,300 | 180,000 | 0.05% | ||
| 48 | RAYMOND JAMES & ASSOCIATES | 12,356 | 168,000 | 0.04% | ||
| 49 | Laurion Capital Management LP | 11,000 | 149,000 | 0.04% | ||
| 50 | NEW YORK STATE COMMON RETIREMENT FUND | 10,700 | 145,000 | 0.04% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
