| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 4,876,567 | 52,765,000 | 16.56% | ||
| 2 | Foresite Capital Management II, LLC | 3,967,900 | 42,933,000 | 13.48% | ||
| 3 | Aisling Capital LLC | 2,990,000 | 32,352,000 | 10.15% | ||
| 4 | TLP GROUP LLC | 2,833,285 | 30,656,000 | 9.62% | ||
| 5 | EAGLE ASSET MANAGEMENT INC | 1,988,434 | 21,514,000 | 6.75% | ||
| 6 | VANGUARD GROUP INC | 1,339,847 | 14,497,000 | 4.55% | ||
| 7 | RA CAPITAL MANAGEMENT, L.P. | 1,292,940 | 13,990,000 | 4.39% | ||
| 8 | PICTET ASSET MANAGEMENT LTD | 831,093 | 12,757,000 | 4.00% | ||
| 9 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,116,400 | 12,079,000 | 3.79% | ||
| 10 | VIVO CAPITAL, LLC | 763,009 | 8,256,000 | 2.59% | ||
| 11 | ALLIANCEBERNSTEIN L.P. | 742,217 | 8,031,000 | 2.52% | ||
| 12 | BAKER BROS. ADVISORS LP | 673,908 | 7,292,000 | 2.29% | ||
| 13 | BlackRock Fund Advisors | 622,563 | 6,736,000 | 2.11% | ||
| 14 | PRICE T ROWE ASSOCIATES INC /MD/ | 604,098 | 6,536,000 | 2.05% | ||
| 15 | RS INVESTMENT MANAGEMENT CO LLC | 538,230 | 5,824,000 | 1.83% | ||
| 16 | STATE STREET CORP | 354,062 | 3,831,000 | 1.20% | ||
| 17 | EMERALD MUTUAL FUND ADVISERS TRUST | 332,625 | 3,599,000 | 1.13% | ||
| 18 | Palo Alto Investors LP | 325,599 | 3,523,000 | 1.11% | ||
| 19 | Rock Springs Capital Management LP | 293,000 | 3,170,000 | 0.99% | ||
| 20 | EMERALD ADVISERS, LLC | 270,510 | 2,927,000 | 0.92% | ||
| 21 | BlackRock Institutional Trust Company, N.A. | 257,509 | 2,786,000 | 0.87% | ||
| 22 | FORESITE CAPITAL MANAGEMENT III, LLC | 235,020 | 2,543,000 | 0.80% | ||
| 23 | MORGAN STANLEY | 199,969 | 2,164,000 | 0.68% | ||
| 24 | NORTHERN TRUST CORP | 138,598 | 1,500,000 | 0.47% | ||
| 25 | BANK OF AMERICA CORP /DE/ | 134,280 | 1,453,000 | 0.46% | ||
| 26 | GEODE CAPITAL MANAGEMENT, LLC | 112,106 | 1,212,000 | 0.38% | ||
| 27 | JPMORGAN CHASE & CO | 105,975 | 1,147,000 | 0.36% | ||
| 28 | AMERICAN CENTURY COMPANIES INC | 98,261 | 1,063,000 | 0.33% | ||
| 29 | BlackRock Investment Management, LLC | 96,041 | 1,039,000 | 0.33% | ||
| 30 | TIAA CREF INVESTMENT MANAGEMENT LLC | 84,098 | 910,000 | 0.29% | ||
| 31 | Bank of New York Mellon Corp | 82,661 | 895,000 | 0.28% | ||
| 32 | DEUTSCHE BANK AG\ | 74,895 | 809,000 | 0.25% | ||
| 33 | ALPS ADVISORS INC | 59,351 | 642,000 | 0.20% | ||
| 34 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 55,115 | 596,000 | 0.19% | ||
| 35 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 51,994 | 563,000 | 0.18% | ||
| 36 | WELLS FARGO & COMPANY/MN | 51,479 | 558,000 | 0.18% | ||
| 37 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 48,270 | 522,000 | 0.16% | ||
| 38 | J.P. Morgan Private Wealth Advisors LLC | 45,750 | 495,000 | 0.16% | ||
| 39 | TEACHERS ADVISORS, LLC | 42,204 | 457,000 | 0.14% | ||
| 40 | Swiss National Bank | 31,474 | 341,000 | 0.11% | ||
| 41 | NEW YORK STATE COMMON RETIREMENT FUND | 26,900 | 291,000 | 0.09% | ||
| 42 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 21,271 | 230,000 | 0.07% | ||
| 43 | RHUMBLINE ADVISERS | 21,200 | 229,000 | 0.07% | ||
| 44 | METROPOLITAN LIFE INSURANCE CO/NY | 20,796 | 225,000 | 0.07% | ||
| 45 | D. E. Shaw & Co., Inc. | 19,849 | 215,000 | 0.07% | ||
| 46 | VIRTUS ETF ADVISERS LLC | 19,501 | 211,000 | 0.07% | ||
| 47 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 19,164 | 207,000 | 0.06% | ||
| 48 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 19,047 | 206,000 | 0.06% | ||
| 49 | CITADEL ADVISORS LLC | 17,223 | 186,000 | 0.06% | ||
| 50 | Nationwide Fund Advisors | 16,929 | 183,000 | 0.06% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
