| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Artal Group S.A. | 114,987,547 | 2,059,427,000 | 72.43% | ||
| 2 | FMR LLC | 3,201,241 | 57,334,000 | 2.02% | ||
| 3 | TIAA CREF INVESTMENT MANAGEMENT LLC | 3,107,047 | 55,647,000 | 1.96% | ||
| 4 | WADDELL & REED FINANCIAL INC | 2,927,876 | 52,438,000 | 1.84% | ||
| 5 | VANGUARD GROUP INC | 2,294,755 | 41,099,000 | 1.45% | ||
| 6 | LORD, ABBETT & CO. LLC | 2,281,922 | 40,869,000 | 1.44% | ||
| 7 | PRICE T ROWE ASSOCIATES INC /MD/ | 2,266,200 | 40,588,000 | 1.43% | ||
| 8 | Capital Research Global Investors | 2,248,110 | 40,264,000 | 1.42% | ||
| 9 | GOLDMAN SACHS GROUP INC | 1,990,537 | 35,651,000 | 1.25% | ||
| 10 | ALLIANCEBERNSTEIN L.P. | 1,478,967 | 26,488,000 | 0.93% | ||
| 11 | FEDERATED HERMES, INC. | 1,049,000 | 18,788,000 | 0.66% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 1,033,858 | 18,516,000 | 0.65% | ||
| 13 | Select Equity Group, L.P. | 1,023,658 | 18,333,715 | 0.64% | ||
| 14 | TimesSquare Capital Management, LLC | 945,300 | 16,930,000 | 0.60% | ||
| 15 | RS INVESTMENT MANAGEMENT CO LLC | 872,070 | 15,619,000 | 0.55% | ||
| 16 | SIRIOS CAPITAL MANAGEMENT L P | 825,898 | 14,792,000 | 0.52% | ||
| 17 | TEACHERS ADVISORS, LLC | 759,449 | 13,602,000 | 0.48% | ||
| 18 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 708,861 | 12,696,000 | 0.45% | ||
| 19 | Gotham Asset Management, LLC | 708,152 | 12,683,000 | 0.45% | ||
| 20 | PRIMECAP MANAGEMENT CO/CA/ | 699,100 | 12,521,000 | 0.44% | ||
| 21 | BALYASNY ASSET MANAGEMENT L.P. | 639,152 | 11,447,000 | 0.40% | ||
| 22 | CITADEL ADVISORS LLC | 639,078 | 11,445,000 | 0.40% | ||
| 23 | JANA PARTNERS LLC | 600,000 | 10,746,000 | 0.38% | ||
| 24 | COLUMBUS CIRCLE INVESTORS | 589,796 | 10,563,000 | 0.37% | ||
| 25 | Hitchwood Capital Management LP | 500,000 | 8,955,000 | 0.31% | ||
| 26 | Omega Advisors Inc. | 500,000 | 8,955,000 | 0.31% | ||
| 27 | Lomas Capital Management, LLC | 465,000 | 8,328,000 | 0.29% | ||
| 28 | GILDER GAGNON HOWE & CO LLC | 419,621 | 7,515,000 | 0.26% | ||
| 29 | Alyeska Investment Group, L.P. | 399,863 | 7,162,000 | 0.25% | ||
| 30 | BLACKROCK ADVISORS LLC | 350,793 | 6,283,000 | 0.22% | ||
| 31 | MORGAN STANLEY | 334,968 | 6,000,000 | 0.21% | ||
| 32 | BANK OF AMERICA CORP /DE/ | 333,715 | 5,977,000 | 0.21% | ||
| 33 | DEUTSCHE BANK AG\ | 326,637 | 5,846,000 | 0.21% | ||
| 34 | PUTNAM INVESTMENTS LLC | 321,418 | 5,757,000 | 0.20% | ||
| 35 | RENAISSANCE TECHNOLOGIES LLC | 319,842 | 5,728,000 | 0.20% | ||
| 36 | BlackRock Fund Advisors | 311,515 | 5,579,000 | 0.20% | ||
| 37 | Allianz Asset Management GmbH | 283,310 | 5,074,000 | 0.18% | ||
| 38 | BAMCO INC /NY/ | 278,061 | 4,980,000 | 0.18% | ||
| 39 | BlackRock Group LTD | 277,460 | 4,969,000 | 0.17% | ||
| 40 | GEODE CAPITAL MANAGEMENT, LLC | 266,022 | 4,764,000 | 0.17% | ||
| 41 | Invesco Ltd. | 258,610 | 4,632,000 | 0.16% | ||
| 42 | JPMORGAN CHASE & CO | 254,500 | 4,559,000 | 0.16% | ||
| 43 | MARSICO CAPITAL MANAGEMENT LLC | 250,000 | 4,477,000 | 0.16% | ||
| 44 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 238,247 | 4,267,000 | 0.15% | ||
| 45 | STATE STREET CORP | 234,000 | 4,191,000 | 0.15% | ||
| 46 | MOORE CAPITAL MANAGEMENT, LP | 225,000 | 4,030,000 | 0.14% | ||
| 47 | OppenheimerFunds, Inc. | 202,450 | 3,626,000 | 0.13% | ||
| 48 | AMERIPRISE FINANCIAL INC | 194,614 | 3,486,000 | 0.12% | ||
| 49 | STEADFAST CAPITAL MANAGEMENT LP | 191,915 | 3,437,000 | 0.12% | ||
| 50 | BTG Pactual Global Asset Management Ltd | 191,700 | 3,433,000 | 0.12% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
