| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Artal Group S.A. | 114,987,547 | 2,683,809,000 | 64.72% | ||
| 2 | VANGUARD GROUP INC | 5,299,211 | 123,683,000 | 2.98% | ||
| 3 | GOLDMAN SACHS GROUP INC | 4,792,458 | 111,856,000 | 2.70% | ||
| 4 | Hitchwood Capital Management LP | 3,600,000 | 84,024,000 | 2.03% | ||
| 5 | WADDELL & REED FINANCIAL INC | 3,127,846 | 73,004,000 | 1.76% | ||
| 6 | Capital Research Global Investors | 2,899,910 | 67,684,000 | 1.63% | ||
| 7 | Neuberger Berman Group LLC | 2,593,167 | 60,525,000 | 1.46% | ||
| 8 | LORD, ABBETT & CO. LLC | 2,457,872 | 57,367,000 | 1.38% | ||
| 9 | CITADEL ADVISORS LLC | 2,445,140 | 57,070,000 | 1.38% | ||
| 10 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,926,538 | 44,965,000 | 1.08% | ||
| 11 | Bank of New York Mellon Corp | 1,886,140 | 44,021,000 | 1.06% | ||
| 12 | AMERICAN CENTURY COMPANIES INC | 1,654,589 | 38,618,000 | 0.93% | ||
| 13 | BlackRock Institutional Trust Company, N.A. | 1,451,799 | 33,885,000 | 0.82% | ||
| 14 | Clearbridge Investments, LLC | 1,367,663 | 31,921,000 | 0.77% | ||
| 15 | TimesSquare Capital Management, LLC | 1,288,500 | 30,074,000 | 0.73% | ||
| 16 | AMERIPRISE FINANCIAL INC | 1,284,600 | 29,983,000 | 0.72% | ||
| 17 | FMR LLC | 1,206,376 | 28,157,000 | 0.68% | ||
| 18 | FEDERATED HERMES, INC. | 1,052,995 | 24,577,000 | 0.59% | ||
| 19 | COLUMBUS CIRCLE INVESTORS | 991,243 | 23,136,000 | 0.56% | ||
| 20 | VOYA INVESTMENT MANAGEMENT LLC | 895,650 | 20,904,000 | 0.50% | ||
| 21 | ALLIANCEBERNSTEIN L.P. | 866,572 | 20,226,000 | 0.49% | ||
| 22 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 857,572 | 20,016,000 | 0.48% | ||
| 23 | PRIMECAP MANAGEMENT CO/CA/ | 805,717 | 18,805,000 | 0.45% | ||
| 24 | EATON VANCE MANAGEMENT | 707,776 | 16,519,000 | 0.40% | ||
| 25 | MILLENNIUM MANAGEMENT LLC | 700,467 | 16,349,000 | 0.39% | ||
| 26 | J. Goldman & Co LP | 683,601 | 15,955,000 | 0.38% | ||
| 27 | BALYASNY ASSET MANAGEMENT L.P. | 647,462 | 15,112,000 | 0.36% | ||
| 28 | STATE STREET CORP | 546,047 | 12,747,000 | 0.31% | ||
| 29 | BlackRock Fund Advisors | 533,948 | 12,462,000 | 0.30% | ||
| 30 | NORGES BANK | 507,653 | 11,849,000 | 0.29% | ||
| 31 | Invesco Ltd. | 500,631 | 11,684,000 | 0.28% | ||
| 32 | BANK OF AMERICA CORP /DE/ | 450,948 | 10,525,000 | 0.25% | ||
| 33 | CREDIT SUISSE AG/ | 415,669 | 9,702,000 | 0.23% | ||
| 34 | Laurion Capital Management LP | 400,000 | 9,336,000 | 0.23% | ||
| 35 | DEUTSCHE BANK AG\ | 400,105 | 9,336,000 | 0.23% | ||
| 36 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 385,620 | 9,001,000 | 0.22% | ||
| 37 | CITIGROUP INC | 357,552 | 8,346,000 | 0.20% | ||
| 38 | MORGAN STANLEY | 344,520 | 8,041,000 | 0.19% | ||
| 39 | HALSEY ASSOCIATES INC/CT | 343,962 | 8,028,000 | 0.19% | ||
| 40 | GEODE CAPITAL MANAGEMENT, LLC | 338,626 | 7,903,000 | 0.19% | ||
| 41 | PRUDENTIAL FINANCIAL INC | 320,000 | 7,469,000 | 0.18% | ||
| 42 | MARSHALL WACE, LLP | 319,200 | 7,450,000 | 0.18% | ||
| 43 | AMUNDI ASSET MANAGEMENT US, INC. | 319,152 | 7,449,000 | 0.18% | ||
| 44 | TWO SIGMA INVESTMENTS, LP | 318,470 | 7,433,000 | 0.18% | ||
| 45 | D. E. Shaw & Co., Inc. | 301,928 | 7,047,000 | 0.17% | ||
| 46 | RENAISSANCE TECHNOLOGIES LLC | 271,200 | 6,330,000 | 0.15% | ||
| 47 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 247,700 | 5,781,000 | 0.14% | ||
| 48 | BRANT POINT INVESTMENT MANAGEMENT LLC | 235,000 | 5,485,000 | 0.13% | ||
| 49 | NORTHERN TRUST CORP | 228,318 | 5,329,000 | 0.13% | ||
| 50 | Pier Capital, LLC | 221,966 | 5,181,000 | 0.12% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
