| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Artal Group S.A. | 87,460,875 | 2,078,070,000 | 51.79% | ||
| 2 | PRICE T ROWE ASSOCIATES INC /MD/ | 9,535,697 | 226,568,000 | 5.65% | ||
| 3 | VANGUARD GROUP INC | 6,455,241 | 153,377,000 | 3.82% | ||
| 4 | GOLDMAN SACHS GROUP INC | 5,473,177 | 130,042,000 | 3.24% | ||
| 5 | Hitchwood Capital Management LP | 3,600,000 | 85,536,000 | 2.13% | ||
| 6 | WADDELL & REED FINANCIAL INC | 2,916,375 | 69,293,000 | 1.73% | ||
| 7 | Capital Research Global Investors | 2,899,910 | 68,902,000 | 1.72% | ||
| 8 | Neuberger Berman Group LLC | 2,575,713 | 61,199,000 | 1.53% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 2,439,087 | 57,953,000 | 1.44% | ||
| 10 | AMERICAN CENTURY COMPANIES INC | 2,106,551 | 50,052,000 | 1.25% | ||
| 11 | Bank of New York Mellon Corp | 2,010,132 | 47,762,000 | 1.19% | ||
| 12 | CITADEL ADVISORS LLC | 1,774,099 | 42,153,000 | 1.05% | ||
| 13 | LORD, ABBETT & CO. LLC | 1,594,041 | 37,874,000 | 0.94% | ||
| 14 | Clearbridge Investments, LLC | 1,556,496 | 36,982,000 | 0.92% | ||
| 15 | TimesSquare Capital Management, LLC | 1,501,100 | 35,666,000 | 0.89% | ||
| 16 | FEDERATED HERMES, INC. | 1,341,613 | 31,876,000 | 0.79% | ||
| 17 | FRONTIER CAPITAL MANAGEMENT CO LLC | 1,323,408 | 31,444,000 | 0.78% | ||
| 18 | EATON VANCE MANAGEMENT | 1,305,455 | 31,018,000 | 0.77% | ||
| 19 | AMERIPRISE FINANCIAL INC | 1,292,404 | 30,692,000 | 0.76% | ||
| 20 | Alyeska Investment Group, L.P. | 1,121,134 | 26,638,000 | 0.66% | ||
| 21 | RENAISSANCE TECHNOLOGIES LLC | 1,087,600 | 25,841,000 | 0.64% | ||
| 22 | MORGAN STANLEY | 1,055,520 | 25,079,000 | 0.63% | ||
| 23 | VOYA INVESTMENT MANAGEMENT LLC | 994,456 | 23,628,000 | 0.59% | ||
| 24 | FMR LLC | 913,050 | 21,694,000 | 0.54% | ||
| 25 | BALYASNY ASSET MANAGEMENT L.P. | 878,514 | 20,874,000 | 0.52% | ||
| 26 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 854,911 | 20,313,000 | 0.51% | ||
| 27 | NORGES BANK | 857,653 | 19,463,000 | 0.49% | ||
| 28 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 814,070 | 19,343,000 | 0.48% | ||
| 29 | MILLENNIUM MANAGEMENT LLC | 811,375 | 19,278,000 | 0.48% | ||
| 30 | STATE STREET CORP | 704,969 | 16,747,000 | 0.42% | ||
| 31 | COLUMBUS CIRCLE INVESTORS | 678,677 | 16,125,000 | 0.40% | ||
| 32 | GEODE CAPITAL MANAGEMENT, LLC | 651,741 | 15,484,000 | 0.39% | ||
| 33 | PRIMECAP MANAGEMENT CO/CA/ | 627,500 | 14,909,000 | 0.37% | ||
| 34 | BlackRock Fund Advisors | 577,531 | 13,722,000 | 0.34% | ||
| 35 | Invesco Ltd. | 566,137 | 13,451,000 | 0.34% | ||
| 36 | J. Goldman & Co LP | 535,598 | 12,726,000 | 0.32% | ||
| 37 | WELLS FARGO & COMPANY/MN | 507,431 | 12,056,000 | 0.30% | ||
| 38 | Connor, Clark & Lunn Investment Management Ltd. | 460,700 | 10,946,000 | 0.27% | ||
| 39 | BANK OF AMERICA CORP /DE/ | 448,237 | 10,650,000 | 0.27% | ||
| 40 | BOSTON ADVISORS LLC | 442,994 | 10,526,000 | 0.26% | ||
| 41 | DEUTSCHE BANK AG\ | 400,950 | 9,524,000 | 0.24% | ||
| 42 | NORTHERN TRUST CORP | 398,335 | 9,465,000 | 0.24% | ||
| 43 | CREDIT SUISSE AG/ | 389,726 | 9,260,000 | 0.23% | ||
| 44 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 389,483 | 9,254,000 | 0.23% | ||
| 45 | TIAA CREF INVESTMENT MANAGEMENT LLC | 379,483 | 9,017,000 | 0.22% | ||
| 46 | DIMENSIONAL FUND ADVISORS LP | 360,332 | 8,562,000 | 0.21% | ||
| 47 | HALSEY ASSOCIATES INC/CT | 358,395 | 8,515,000 | 0.21% | ||
| 48 | BARCLAYS PLC | 341,074 | 8,105,000 | 0.20% | ||
| 49 | VIRTUS CAPITAL ADVISERS, LLC | 339,777 | 8,073,000 | 0.20% | ||
| 50 | Nationwide Fund Advisors | 329,950 | 7,840,000 | 0.20% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
