| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Artal Group S.A. | 114,987,547 | 2,950,580,000 | 69.85% | ||
| 2 | GOLDMAN SACHS GROUP INC | 4,840,082 | 124,196,000 | 2.94% | ||
| 3 | Hitchwood Capital Management LP | 3,500,000 | 89,810,000 | 2.13% | ||
| 4 | WADDELL & REED FINANCIAL INC | 3,135,170 | 80,449,000 | 1.90% | ||
| 5 | Capital Research Global Investors | 2,899,910 | 74,412,000 | 1.76% | ||
| 6 | VANGUARD GROUP INC | 2,731,544 | 70,091,000 | 1.66% | ||
| 7 | LORD, ABBETT & CO. LLC | 2,547,586 | 65,371,000 | 1.55% | ||
| 8 | Neuberger Berman Group LLC | 2,513,164 | 64,488,000 | 1.53% | ||
| 9 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,923,138 | 49,348,000 | 1.17% | ||
| 10 | CITADEL ADVISORS LLC | 1,690,527 | 43,379,000 | 1.03% | ||
| 11 | ALLIANCEBERNSTEIN L.P. | 1,673,966 | 42,954,000 | 1.02% | ||
| 12 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 1,664,375 | 42,707,000 | 1.01% | ||
| 13 | Clearbridge Investments, LLC | 1,310,105 | 33,617,000 | 0.80% | ||
| 14 | TimesSquare Capital Management, LLC | 1,250,300 | 32,083,000 | 0.76% | ||
| 15 | BlackRock Institutional Trust Company, N.A. | 1,095,026 | 28,098,000 | 0.67% | ||
| 16 | PRIMECAP MANAGEMENT CO/CA/ | 982,400 | 25,208,000 | 0.60% | ||
| 17 | AMERIPRISE FINANCIAL INC | 960,537 | 24,644,000 | 0.58% | ||
| 18 | FMR LLC | 922,676 | 23,676,000 | 0.56% | ||
| 19 | COLUMBUS CIRCLE INVESTORS | 884,698 | 22,701,000 | 0.54% | ||
| 20 | BALYASNY ASSET MANAGEMENT L.P. | 802,588 | 20,594,000 | 0.49% | ||
| 21 | VOYA INVESTMENT MANAGEMENT LLC | 791,417 | 20,307,000 | 0.48% | ||
| 22 | FEDERATED HERMES, INC. | 774,500 | 19,874,000 | 0.47% | ||
| 23 | EATON VANCE MANAGEMENT | 743,486 | 19,078,000 | 0.45% | ||
| 24 | BANK OF AMERICA CORP /DE/ | 486,635 | 12,487,000 | 0.30% | ||
| 25 | Invesco Ltd. | 466,677 | 11,975,000 | 0.28% | ||
| 26 | STATE STREET CORP | 453,795 | 11,647,000 | 0.28% | ||
| 27 | Jupiter Investment Management Ltd | 385,511 | 9,892,000 | 0.23% | ||
| 28 | TWO SIGMA INVESTMENTS, LP | 374,671 | 9,614,000 | 0.23% | ||
| 29 | MORGAN STANLEY | 351,923 | 9,031,000 | 0.21% | ||
| 30 | HALSEY ASSOCIATES INC/CT | 335,587 | 8,611,000 | 0.20% | ||
| 31 | BlackRock Fund Advisors | 334,892 | 8,593,000 | 0.20% | ||
| 32 | AMUNDI ASSET MANAGEMENT US, INC. | 319,663 | 8,203,000 | 0.19% | ||
| 33 | GEODE CAPITAL MANAGEMENT, LLC | 317,262 | 8,140,000 | 0.19% | ||
| 34 | CREDIT SUISSE AG/ | 313,946 | 8,056,000 | 0.19% | ||
| 35 | Allianz Asset Management GmbH | 285,591 | 7,328,000 | 0.17% | ||
| 36 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 254,430 | 6,528,000 | 0.15% | ||
| 37 | Pier Capital, LLC | 228,021 | 5,851,000 | 0.14% | ||
| 38 | DEUTSCHE BANK AG\ | 227,800 | 5,843,000 | 0.14% | ||
| 39 | BlueCrest Capital Management Ltd | 197,817 | 5,076,000 | 0.12% | ||
| 40 | STEADFAST CAPITAL MANAGEMENT LP | 191,915 | 4,925,000 | 0.12% | ||
| 41 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 189,600 | 4,865,000 | 0.12% | ||
| 42 | GUGGENHEIM CAPITAL LLC | 171,638 | 4,404,000 | 0.10% | ||
| 43 | NORGES BANK | 166,554 | 4,274,000 | 0.10% | ||
| 44 | NORTHERN TRUST CORP | 160,198 | 4,111,000 | 0.10% | ||
| 45 | SEI INVESTMENTS CO | 157,400 | 4,039,000 | 0.10% | ||
| 46 | MILLENNIUM MANAGEMENT LLC | 148,697 | 3,816,000 | 0.09% | ||
| 47 | Engineers Gate Manager LP | 145,082 | 3,723,000 | 0.09% | ||
| 48 | State of New Jersey Common Pension Fund D | 145,000 | 3,721,000 | 0.09% | ||
| 49 | VIRTUS CAPITAL ADVISERS, LLC | 143,333 | 3,678,000 | 0.09% | ||
| 50 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 125,900 | 3,231,000 | 0.08% | Call |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
