| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Artal Group S.A. | 87,460,875 | 2,102,559,000 | 51.78% | ||
| 2 | PRICE T ROWE ASSOCIATES INC /MD/ | 8,827,299 | 212,208,000 | 5.23% | ||
| 3 | VANGUARD GROUP INC | 6,768,202 | 162,707,000 | 4.01% | ||
| 4 | GOLDMAN SACHS GROUP INC | 5,174,278 | 124,390,000 | 3.06% | ||
| 5 | Neuberger Berman Group LLC | 4,424,948 | 106,376,000 | 2.62% | ||
| 6 | Bank of New York Mellon Corp | 3,474,724 | 83,531,000 | 2.06% | ||
| 7 | Artisan Partners Limited Partnership | 3,359,713 | 80,767,000 | 1.99% | ||
| 8 | Hitchwood Capital Management LP | 3,300,000 | 79,332,000 | 1.95% | ||
| 9 | WADDELL & REED FINANCIAL INC | 2,993,138 | 71,955,000 | 1.77% | ||
| 10 | Capital Research Global Investors | 2,899,910 | 69,714,000 | 1.72% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 2,405,410 | 57,826,000 | 1.42% | ||
| 12 | AMERICAN CENTURY COMPANIES INC | 2,405,021 | 57,817,000 | 1.42% | ||
| 13 | WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 2,233,215 | 53,686,000 | 1.32% | ||
| 14 | Clearbridge Investments, LLC | 2,075,336 | 49,891,000 | 1.23% | ||
| 15 | TimesSquare Capital Management, LLC | 1,637,650 | 39,369,000 | 0.97% | ||
| 16 | FRONTIER CAPITAL MANAGEMENT CO LLC | 1,418,718 | 34,106,000 | 0.84% | ||
| 17 | AMERIPRISE FINANCIAL INC | 1,368,873 | 32,907,000 | 0.81% | ||
| 18 | FEDERATED HERMES, INC. | 1,330,831 | 31,993,000 | 0.79% | ||
| 19 | EATON VANCE MANAGEMENT | 1,248,091 | 30,004,000 | 0.74% | ||
| 20 | RENAISSANCE TECHNOLOGIES LLC | 1,181,000 | 28,391,000 | 0.70% | ||
| 21 | VOYA INVESTMENT MANAGEMENT LLC | 1,114,605 | 26,794,000 | 0.66% | ||
| 22 | NORGES BANK | 963,226 | 23,156,000 | 0.57% | ||
| 23 | WELLS FARGO & COMPANY/MN | 886,018 | 21,301,000 | 0.52% | ||
| 24 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 864,467 | 20,782,000 | 0.51% | ||
| 25 | FMR LLC | 811,750 | 19,514,000 | 0.48% | ||
| 26 | STATE STREET CORP | 747,772 | 17,981,000 | 0.44% | ||
| 27 | FIRST TRUST ADVISORS LP | 703,423 | 16,910,000 | 0.42% | ||
| 28 | GEODE CAPITAL MANAGEMENT, LLC | 677,825 | 16,294,000 | 0.40% | ||
| 29 | MORGAN STANLEY | 675,034 | 16,227,000 | 0.40% | ||
| 30 | Invesco Ltd. | 642,149 | 15,437,000 | 0.38% | ||
| 31 | PRIMECAP MANAGEMENT CO/CA/ | 627,000 | 15,073,000 | 0.37% | ||
| 32 | Connor, Clark & Lunn Investment Management Ltd. | 612,950 | 14,735,000 | 0.36% | ||
| 33 | DIMENSIONAL FUND ADVISORS LP | 603,176 | 14,500,000 | 0.36% | ||
| 34 | BlackRock Fund Advisors | 596,223 | 14,333,000 | 0.35% | ||
| 35 | Allianz Asset Management GmbH | 531,111 | 12,768,000 | 0.31% | ||
| 36 | TIAA CREF INVESTMENT MANAGEMENT LLC | 469,356 | 11,283,000 | 0.28% | ||
| 37 | BOSTON ADVISORS LLC | 447,379 | 10,755,000 | 0.26% | ||
| 38 | NORTHERN TRUST CORP | 417,961 | 10,048,000 | 0.25% | ||
| 39 | CREDIT SUISSE AG/ | 404,907 | 9,734,000 | 0.24% | ||
| 40 | HALSEY ASSOCIATES INC/CT | 388,238 | 9,333,000 | 0.23% | ||
| 41 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 367,022 | 8,823,000 | 0.22% | ||
| 42 | BANK OF AMERICA CORP /DE/ | 353,272 | 8,492,000 | 0.21% | ||
| 43 | OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 347,767 | 8,360,000 | 0.21% | ||
| 44 | VIRTUS CAPITAL ADVISERS, LLC | 339,263 | 8,156,000 | 0.20% | ||
| 45 | Nationwide Fund Advisors | 329,950 | 7,932,000 | 0.20% | ||
| 46 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 325,184 | 7,818,000 | 0.19% | ||
| 47 | AMUNDI ASSET MANAGEMENT US, INC. | 309,752 | 7,446,000 | 0.18% | ||
| 48 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 299,230 | 7,193,000 | 0.18% | ||
| 49 | Vigilant Capital Management, LLC | 292,193 | 7,024,000 | 0.17% | ||
| 50 | MANNING & NAPIER ADVISORS LLC | 282,200 | 6,783,000 | 0.17% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
