| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Artal Group S.A. | 87,460,875 | 2,011,600,000 | 49.90% | ||
| 2 | PRICE T ROWE ASSOCIATES INC /MD/ | 7,999,310 | 183,984,000 | 4.56% | ||
| 3 | VANGUARD GROUP INC | 6,762,650 | 155,541,000 | 3.86% | ||
| 4 | Neuberger Berman Group LLC | 4,914,387 | 113,031,000 | 2.80% | ||
| 5 | GOLDMAN SACHS GROUP INC | 3,528,793 | 81,162,000 | 2.01% | ||
| 6 | Clearbridge Investments, LLC | 3,523,195 | 81,033,000 | 2.01% | ||
| 7 | Bank of New York Mellon Corp | 3,482,949 | 80,108,000 | 1.99% | ||
| 8 | Artisan Partners Limited Partnership | 3,278,067 | 75,396,000 | 1.87% | ||
| 9 | BlackRock Finance, Inc. | 3,136,708 | 72,145,000 | 1.79% | ||
| 10 | WADDELL & REED FINANCIAL INC | 2,972,343 | 68,364,000 | 1.70% | ||
| 11 | Capital Research Global Investors | 2,899,910 | 66,698,000 | 1.65% | ||
| 12 | WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 2,446,262 | 56,264,000 | 1.40% | ||
| 13 | AMERICAN CENTURY COMPANIES INC | 2,381,528 | 54,775,000 | 1.36% | ||
| 14 | RENAISSANCE TECHNOLOGIES LLC | 2,226,700 | 51,214,000 | 1.27% | ||
| 15 | Hitchwood Capital Management LP | 2,205,743 | 50,732,000 | 1.26% | ||
| 16 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 2,066,507 | 47,530,000 | 1.18% | ||
| 17 | AMERIPRISE FINANCIAL INC | 1,729,731 | 39,784,000 | 0.99% | ||
| 18 | TimesSquare Capital Management, LLC | 1,632,800 | 37,554,000 | 0.93% | ||
| 19 | EATON VANCE MANAGEMENT | 1,521,304 | 34,990,000 | 0.87% | ||
| 20 | WELLS FARGO & COMPANY/MN | 1,414,921 | 32,543,000 | 0.81% | ||
| 21 | FRONTIER CAPITAL MANAGEMENT CO LLC | 1,354,928 | 31,163,000 | 0.77% | ||
| 22 | VOYA INVESTMENT MANAGEMENT LLC | 1,178,590 | 27,108,000 | 0.67% | ||
| 23 | NORGES BANK | 1,146,641 | 26,373,000 | 0.65% | ||
| 24 | MACKENZIE FINANCIAL CORP | 1,056,711 | 24,304,000 | 0.60% | ||
| 25 | FEDERATED HERMES, INC. | 1,050,483 | 24,161,000 | 0.60% | ||
| 26 | Echo Street Capital Management LLC | 979,671 | 22,532,000 | 0.56% | ||
| 27 | FIRST TRUST ADVISORS LP | 845,656 | 19,450,000 | 0.48% | ||
| 28 | Invesco Ltd. | 828,492 | 19,055,000 | 0.47% | ||
| 29 | STATE STREET CORP | 797,459 | 18,344,000 | 0.46% | ||
| 30 | DIMENSIONAL FUND ADVISORS LP | 786,099 | 18,080,000 | 0.45% | ||
| 31 | GEODE CAPITAL MANAGEMENT, LLC | 756,173 | 17,391,000 | 0.43% | ||
| 32 | FMR LLC | 720,950 | 16,582,000 | 0.41% | ||
| 33 | Connor, Clark & Lunn Investment Management Ltd. | 708,100 | 16,286,000 | 0.40% | ||
| 34 | ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 622,371 | 14,315,000 | 0.36% | ||
| 35 | PRIMECAP MANAGEMENT CO/CA/ | 548,200 | 12,609,000 | 0.31% | ||
| 36 | Allianz Asset Management GmbH | 499,411 | 11,486,000 | 0.28% | ||
| 37 | ACADIAN ASSET MANAGEMENT LLC | 497,829 | 11,449,000 | 0.28% | ||
| 38 | HALSEY ASSOCIATES INC/CT | 478,187 | 10,998,000 | 0.27% | ||
| 39 | NORTHERN TRUST CORP | 430,383 | 9,899,000 | 0.25% | ||
| 40 | BOSTON ADVISORS LLC | 404,605 | 9,306,000 | 0.23% | ||
| 41 | PRUDENTIAL FINANCIAL INC | 377,600 | 8,685,000 | 0.22% | ||
| 42 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 359,227 | 8,262,221 | 0.20% | ||
| 43 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 347,005 | 7,982,000 | 0.20% | ||
| 44 | MORGAN STANLEY | 345,472 | 7,946,000 | 0.20% | ||
| 45 | VIRTUS CAPITAL ADVISERS, LLC | 335,450 | 7,715,000 | 0.19% | ||
| 46 | Vigilant Capital Management, LLC | 329,843 | 7,586,000 | 0.19% | ||
| 47 | Nationwide Fund Advisors | 328,780 | 7,562,000 | 0.19% | ||
| 48 | AMUNDI ASSET MANAGEMENT US, INC. | 308,429 | 7,094,000 | 0.18% | ||
| 49 | TIAA CREF INVESTMENT MANAGEMENT LLC | 304,324 | 6,999,000 | 0.17% | ||
| 50 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 299,420 | 6,887,000 | 0.17% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
