| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | MPM ASSET MANAGEMENT LLC | 5,681,544 | 112,949,000 | 36.39% | ||
| 2 | FMR LLC | 3,125,339 | 62,132,000 | 20.02% | ||
| 3 | Abingworth LLP | 2,080,595 | 41,362,000 | 13.33% | ||
| 4 | FRANKLIN RESOURCES INC | 615,200 | 12,231,000 | 3.94% | ||
| 5 | ALLIANCEBERNSTEIN L.P. | 596,519 | 11,859,000 | 3.82% | ||
| 6 | MILLENNIUM MANAGEMENT LLC | 556,655 | 11,066,000 | 3.57% | ||
| 7 | Rock Springs Capital Management LP | 522,500 | 10,387,000 | 3.35% | ||
| 8 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 246,929 | 4,909,000 | 1.58% | ||
| 9 | Pier Capital, LLC | 246,641 | 4,903,000 | 1.58% | ||
| 10 | VANGUARD GROUP INC | 199,802 | 3,972,000 | 1.28% | ||
| 11 | BlackRock Fund Advisors | 191,923 | 3,815,000 | 1.23% | ||
| 12 | CREDIT SUISSE AG/ | 169,756 | 3,375,000 | 1.09% | ||
| 13 | BlackRock Institutional Trust Company, N.A. | 166,296 | 3,306,000 | 1.07% | ||
| 14 | WELLINGTON MANAGEMENT GROUP LLP | 156,150 | 3,104,000 | 1.00% | ||
| 15 | JPMORGAN CHASE & CO | 152,300 | 3,027,000 | 0.98% | ||
| 16 | Invesco Ltd. | 146,776 | 2,917,000 | 0.94% | ||
| 17 | PUTNAM INVESTMENTS LLC | 96,351 | 1,915,000 | 0.62% | ||
| 18 | Allianz Asset Management GmbH | 75,317 | 1,497,000 | 0.48% | ||
| 19 | STATE STREET CORP | 69,338 | 1,380,000 | 0.44% | ||
| 20 | Ghost Tree Capital, LLC | 65,000 | 1,292,000 | 0.42% | ||
| 21 | COMMERZBANK AKTIENGESELLSCHAFT /FI | 52,008 | 1,034,000 | 0.33% | ||
| 22 | GLG LLC | 51,606 | 1,026,000 | 0.33% | ||
| 23 | GEODE CAPITAL MANAGEMENT, LLC | 40,385 | 802,000 | 0.26% | ||
| 24 | BLACKROCK ADVISORS LLC | 39,578 | 787,000 | 0.25% | ||
| 25 | PANAGORA ASSET MANAGEMENT INC | 33,464 | 665,000 | 0.21% | ||
| 26 | FRED ALGER MANAGEMENT, LLC | 33,150 | 659,000 | 0.21% | ||
| 27 | NORTHERN TRUST CORP | 24,696 | 491,000 | 0.16% | ||
| 28 | BlackRock Investment Management, LLC | 24,537 | 488,000 | 0.16% | ||
| 29 | FEDERATED HERMES, INC. | 21,000 | 417,000 | 0.13% | ||
| 30 | TIAA CREF INVESTMENT MANAGEMENT LLC | 20,761 | 413,000 | 0.13% | ||
| 31 | BlackRock Group LTD | 17,523 | 348,000 | 0.11% | ||
| 32 | GOLDMAN SACHS GROUP INC | 17,067 | 339,000 | 0.11% | ||
| 33 | Bank of New York Mellon Corp | 16,656 | 331,000 | 0.11% | ||
| 34 | RENAISSANCE TECHNOLOGIES LLC | 15,250 | 303,000 | 0.10% | ||
| 35 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 13,300 | 264,000 | 0.09% | ||
| 36 | Tower Research Capital LLC (TRC) | 8,922 | 177,000 | 0.06% | ||
| 37 | TEACHERS ADVISORS, LLC | 7,572 | 151,000 | 0.05% | ||
| 38 | DEUTSCHE BANK AG\ | 3,748 | 73,000 | 0.02% | ||
| 39 | STRS OHIO | 2,400 | 47,000 | 0.02% | ||
| 40 | UBS Group AG | 1,677 | 33,000 | 0.01% | ||
| 41 | Nationwide Fund Advisors | 1,546 | 31,000 | 0.01% | ||
| 42 | MORGAN STANLEY | 1,385 | 28,000 | 0.01% | ||
| 43 | BNP PARIBAS FINANCIAL MARKETS | 1,358 | 26,997 | 0.01% | ||
| 44 | MAZAMA CAPITAL MANAGEMENT INC | 966 | 19,000 | 0.01% | ||
| 45 | BARCLAYS PLC | 610 | 12,000 | 0.00% | ||
| 46 | ROYAL BANK OF CANADA | 300 | 6,000 | 0.00% | ||
| 47 | BlackRock Japan Co. Ltd | 134 | 3,000 | 0.00% | ||
| 48 | WELLS FARGO & COMPANY/MN | 30 | 1,000 | 0.00% | ||
| 49 | CITIGROUP INC | 1 | 0 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
