| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | MPM ASSET MANAGEMENT LLC | 5,681,544 | 111,188,000 | 36.56% | ||
| 2 | FMR LLC | 3,126,325 | 61,182,000 | 20.12% | ||
| 3 | Abingworth LLP | 2,080,595 | 40,696,000 | 13.38% | ||
| 4 | ALLIANCEBERNSTEIN L.P. | 619,500 | 12,316,000 | 4.05% | ||
| 5 | FRANKLIN RESOURCES INC | 609,240 | 11,922,000 | 3.92% | ||
| 6 | Rock Springs Capital Management LP | 487,500 | 9,540,000 | 3.14% | ||
| 7 | BlackRock Fund Advisors | 477,759 | 9,350,000 | 3.07% | ||
| 8 | MILLENNIUM MANAGEMENT LLC | 311,300 | 6,092,000 | 2.00% | ||
| 9 | Pier Capital, LLC | 281,017 | 5,500,000 | 1.81% | ||
| 10 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 245,178 | 4,798,000 | 1.58% | ||
| 11 | VANGUARD GROUP INC | 222,952 | 4,363,000 | 1.43% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 191,450 | 3,747,000 | 1.23% | ||
| 13 | Invesco Ltd. | 160,328 | 3,137,000 | 1.03% | ||
| 14 | JPMORGAN CHASE & CO | 133,475 | 2,612,000 | 0.86% | ||
| 15 | WELLINGTON MANAGEMENT GROUP LLP | 106,070 | 2,076,000 | 0.68% | ||
| 16 | Allianz Asset Management GmbH | 96,953 | 1,897,000 | 0.62% | ||
| 17 | STATE STREET CORP | 92,526 | 1,813,000 | 0.60% | ||
| 18 | NORTHERN TRUST CORP | 84,855 | 1,661,000 | 0.55% | ||
| 19 | PUTNAM INVESTMENTS LLC | 82,300 | 1,611,000 | 0.53% | ||
| 20 | GEODE CAPITAL MANAGEMENT, LLC | 46,655 | 913,000 | 0.30% | ||
| 21 | BLACKROCK ADVISORS LLC | 38,826 | 760,000 | 0.25% | ||
| 22 | TIAA CREF INVESTMENT MANAGEMENT LLC | 37,403 | 732,000 | 0.24% | ||
| 23 | Bank of New York Mellon Corp | 35,243 | 689,000 | 0.23% | ||
| 24 | ALPS ADVISORS INC | 31,534 | 617,000 | 0.20% | ||
| 25 | BlackRock Investment Management, LLC | 25,190 | 493,000 | 0.16% | ||
| 26 | CITADEL ADVISORS LLC | 22,817 | 447,000 | 0.15% | ||
| 27 | FEDERATED HERMES, INC. | 21,000 | 411,000 | 0.14% | ||
| 28 | ProShare Advisors LLC | 20,317 | 398,000 | 0.13% | ||
| 29 | FRED ALGER MANAGEMENT, LLC | 18,950 | 371,000 | 0.12% | ||
| 30 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 15,023 | 294,000 | 0.10% | ||
| 31 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 13,517 | 265,000 | 0.09% | ||
| 32 | GOLDMAN SACHS GROUP INC | 13,015 | 255,000 | 0.08% | ||
| 33 | Spark Investment Management LLC | 12,900 | 252,000 | 0.08% | ||
| 34 | TEACHERS ADVISORS, LLC | 12,079 | 236,000 | 0.08% | ||
| 35 | Swiss National Bank | 11,300 | 221,000 | 0.07% | ||
| 36 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 10,000 | 196,000 | 0.06% | ||
| 37 | BlackRock Group LTD | 6,692 | 131,000 | 0.04% | ||
| 38 | NEW YORK STATE COMMON RETIREMENT FUND | 6,500 | 127,000 | 0.04% | ||
| 39 | CITIGROUP INC | 5,508 | 108,000 | 0.04% | ||
| 40 | VAN ECK ASSOCIATES CORP | 5,477 | 107,000 | 0.04% | ||
| 41 | WELLS FARGO & COMPANY/MN | 4,357 | 85,000 | 0.03% | ||
| 42 | Nationwide Fund Advisors | 4,368 | 85,000 | 0.03% | ||
| 43 | Psagot Value Holdings Ltd. | 4,116 | 81,000 | 0.03% | ||
| 44 | BANK OF AMERICA CORP /DE/ | 4,163 | 81,000 | 0.03% | ||
| 45 | ROYAL BANK OF CANADA | 3,000 | 59,000 | 0.02% | ||
| 46 | STRS OHIO | 2,400 | 46,000 | 0.02% | ||
| 47 | DEUTSCHE BANK AG\ | 2,098 | 40,000 | 0.01% | ||
| 48 | MORGAN STANLEY | 1,347 | 26,000 | 0.01% | ||
| 49 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 1,325 | 26,000 | 0.01% | ||
| 50 | BARCLAYS PLC | 1,066 | 21,000 | 0.01% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
