| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | MPM ASSET MANAGEMENT LLC | 5,681,544 | 52,043,000 | 32.73% | ||
| 2 | FMR LLC | 3,177,099 | 29,102,000 | 18.30% | ||
| 3 | Abingworth LLP | 2,080,595 | 19,037,000 | 11.97% | ||
| 4 | WELLINGTON MANAGEMENT GROUP LLP | 1,245,265 | 11,406,000 | 7.17% | ||
| 5 | FRANKLIN RESOURCES INC | 807,440 | 7,396,000 | 4.65% | ||
| 6 | BlackRock Fund Advisors | 499,143 | 4,572,000 | 2.88% | ||
| 7 | Rock Springs Capital Management LP | 492,500 | 4,511,000 | 2.84% | ||
| 8 | VANGUARD GROUP INC | 339,218 | 3,107,000 | 1.95% | ||
| 9 | ALLIANCEBERNSTEIN L.P. | 337,587 | 3,092,000 | 1.94% | ||
| 10 | Invesco Ltd. | 253,927 | 2,326,000 | 1.46% | ||
| 11 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 248,351 | 2,275,000 | 1.43% | ||
| 12 | J. Goldman & Co LP | 246,077 | 2,254,000 | 1.42% | ||
| 13 | SPHERA FUNDS MANAGEMENT LTD. | 230,649 | 2,113,000 | 1.33% | ||
| 14 | BlackRock Institutional Trust Company, N.A. | 188,796 | 1,729,000 | 1.09% | ||
| 15 | Pier Capital, LLC | 159,474 | 1,461,000 | 0.92% | ||
| 16 | JPMORGAN CHASE & CO | 131,825 | 1,207,000 | 0.76% | ||
| 17 | TFS CAPITAL LLC | 111,842 | 1,024,000 | 0.64% | ||
| 18 | Allianz Asset Management GmbH | 93,228 | 854,000 | 0.54% | ||
| 19 | STATE STREET CORP | 92,278 | 844,000 | 0.53% | ||
| 20 | PUTNAM INVESTMENTS LLC | 86,466 | 792,000 | 0.50% | ||
| 21 | NORTHERN TRUST CORP | 85,322 | 781,000 | 0.49% | ||
| 22 | Ghost Tree Capital, LLC | 75,000 | 687,000 | 0.43% | ||
| 23 | MILLENNIUM MANAGEMENT LLC | 58,438 | 535,000 | 0.34% | ||
| 24 | GEODE CAPITAL MANAGEMENT, LLC | 55,693 | 510,000 | 0.32% | ||
| 25 | FIDUCIARY TRUST INTERNATIONAL LLC | 54,131 | 496,000 | 0.31% | ||
| 26 | Bank of New York Mellon Corp | 45,160 | 414,000 | 0.26% | ||
| 27 | FEDERATED HERMES, INC. | 40,000 | 366,000 | 0.23% | ||
| 28 | BLACKROCK ADVISORS LLC | 39,163 | 359,000 | 0.23% | ||
| 29 | MORGAN STANLEY | 37,691 | 345,000 | 0.22% | ||
| 30 | ALPS ADVISORS INC | 26,920 | 247,000 | 0.16% | ||
| 31 | BlackRock Investment Management, LLC | 25,735 | 236,000 | 0.15% | ||
| 32 | BLAIR WILLIAM & CO/IL | 21,940 | 200,000 | 0.13% | ||
| 33 | TIAA CREF INVESTMENT MANAGEMENT LLC | 21,710 | 199,000 | 0.13% | ||
| 34 | Opaleye Management Inc. | 20,000 | 183,000 | 0.12% | ||
| 35 | Rathbones Group PLC | 18,550 | 170,000 | 0.11% | ||
| 36 | ProShare Advisors LLC | 18,483 | 169,000 | 0.11% | ||
| 37 | GOLDMAN SACHS GROUP INC | 17,407 | 159,000 | 0.10% | ||
| 38 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 15,646 | 143,000 | 0.09% | ||
| 39 | Paloma Partners Management Co | 15,338 | 140,000 | 0.09% | ||
| 40 | Swiss National Bank | 14,600 | 128,000 | 0.08% | ||
| 41 | TEACHERS ADVISORS, LLC | 12,079 | 111,000 | 0.07% | ||
| 42 | Dynamic Technology Lab Private Ltd | 11,657 | 106,000 | 0.07% | ||
| 43 | CREDIT SUISSE AG/ | 11,548 | 106,000 | 0.07% | ||
| 44 | DekaBank Deutsche Girozentrale | 11,500 | 99,000 | 0.06% | ||
| 45 | Quantitative Systematic Strategies LLC | 10,845 | 94,000 | 0.06% | ||
| 46 | CITADEL ADVISORS LLC | 10,266 | 94,000 | 0.06% | ||
| 47 | JACOBS LEVY EQUITY MANAGEMENT, INC | 10,300 | 94,000 | 0.06% | ||
| 48 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 10,000 | 92,000 | 0.06% | ||
| 49 | CITIGROUP INC | 9,068 | 84,000 | 0.05% | ||
| 50 | BlackRock Group LTD | 8,852 | 81,000 | 0.05% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
