| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 4,574,292 | 72,549,000 | 30.37% | ||
| 2 | PERCEPTIVE ADVISORS LLC | 1,297,468 | 20,577,000 | 8.61% | ||
| 3 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,193,811 | 18,934,000 | 7.93% | ||
| 4 | VANGUARD GROUP INC | 835,024 | 13,244,000 | 5.54% | ||
| 5 | JANUS HENDERSON INVESTORS US LLC | 778,457 | 12,347,000 | 5.17% | ||
| 6 | PFM Health Sciences, LP | 742,986 | 11,784,000 | 4.93% | ||
| 7 | BAKER BROS. ADVISORS LP | 600,000 | 9,516,000 | 3.98% | ||
| 8 | GOLDMAN SACHS GROUP INC | 500,000 | 7,930,000 | 3.32% | Call | |
| 9 | FORESITE CAPITAL MANAGEMENT III, LLC | 497,000 | 7,882,000 | 3.30% | ||
| 10 | WELLINGTON MANAGEMENT GROUP LLP | 422,556 | 6,702,000 | 2.81% | ||
| 11 | Iguana Healthcare Management, LLC | 250,000 | 3,965,000 | 1.66% | ||
| 12 | JENNISON ASSOCIATES LLC | 237,317 | 3,764,000 | 1.58% | ||
| 13 | Avoro Capital Advisors LLC | 208,086 | 3,300,000 | 1.38% | ||
| 14 | RTW INVESTMENTS, LP | 190,981 | 3,029,000 | 1.27% | ||
| 15 | JPMORGAN CHASE & CO | 186,000 | 2,950,000 | 1.23% | ||
| 16 | VHCP MANAGEMENT II, LLC | 170,312 | 2,701,000 | 1.13% | ||
| 17 | BlackRock Fund Advisors | 167,182 | 2,652,000 | 1.11% | ||
| 18 | EVENTIDE ASSET MANAGEMENT, LLC | 165,000 | 2,617,000 | 1.10% | ||
| 19 | DRIEHAUS CAPITAL MANAGEMENT LLC | 145,794 | 2,312,000 | 0.97% | ||
| 20 | SABBY MANAGEMENT, LLC | 137,000 | 2,173,000 | 0.91% | ||
| 21 | UBS Group AG | 132,209 | 2,097,000 | 0.88% | ||
| 22 | GOLDMAN SACHS GROUP INC | 128,859 | 2,044,000 | 0.86% | ||
| 23 | Point72 Asset Management, L.P. | 112,300 | 1,781,000 | 0.75% | ||
| 24 | CASDIN CAPITAL, LLC | 105,000 | 1,665,000 | 0.70% | ||
| 25 | STATE STREET CORP | 93,872 | 1,491,000 | 0.62% | ||
| 26 | Spark Investment Management LLC | 90,600 | 1,436,000 | 0.60% | ||
| 27 | Asset Management One Co., Ltd. | 89,659 | 1,342,000 | 0.56% | ||
| 28 | Rock Springs Capital Management LP | 78,000 | 1,237,000 | 0.52% | ||
| 29 | NORTHERN TRUST CORP | 75,884 | 1,204,000 | 0.50% | ||
| 30 | BlackRock Institutional Trust Company, N.A. | 75,157 | 1,192,000 | 0.50% | ||
| 31 | VHCP Management, LLC | 72,990 | 1,158,000 | 0.48% | ||
| 32 | DSC Advisors, L.P. | 65,000 | 1,031,000 | 0.43% | ||
| 33 | A.R.T. Advisors, LLC | 56,400 | 894,000 | 0.37% | ||
| 34 | GEODE CAPITAL MANAGEMENT, LLC | 53,433 | 847,000 | 0.35% | ||
| 35 | TFS CAPITAL LLC | 40,343 | 640,000 | 0.27% | ||
| 36 | MORGAN STANLEY | 37,279 | 591,000 | 0.25% | ||
| 37 | BALYASNY ASSET MANAGEMENT L.P. | 30,300 | 481,000 | 0.20% | ||
| 38 | Jefferies Group LLC | 30,000 | 476,000 | 0.20% | Call | |
| 39 | Bank of New York Mellon Corp | 29,960 | 475,000 | 0.20% | ||
| 40 | JACOBS LEVY EQUITY MANAGEMENT, INC | 28,300 | 449,000 | 0.19% | ||
| 41 | EcoR1 Capital, LLC | 28,032 | 445,000 | 0.19% | ||
| 42 | FT OPTIONS LLC | 26,711 | 424,000 | 0.18% | ||
| 43 | BlackRock Investment Management, LLC | 23,841 | 378,000 | 0.16% | ||
| 44 | TIAA CREF INVESTMENT MANAGEMENT LLC | 22,013 | 349,000 | 0.15% | ||
| 45 | Fernwood Investment Management, LLC | 19,950 | 316,000 | 0.13% | ||
| 46 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 19,754 | 314,000 | 0.13% | ||
| 47 | Jupiter Investment Management Ltd | 18,806 | 298,000 | 0.12% | ||
| 48 | CREDIT SUISSE AG/ | 18,371 | 291,000 | 0.12% | ||
| 49 | Partner Investment Management, L.P. | 16,848 | 267,000 | 0.11% | ||
| 50 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 16,600 | 263,000 | 0.11% | Call |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
