| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 5,533,461 | 91,800,000 | 23.48% | ||
| 2 | PERCEPTIVE ADVISORS LLC | 2,207,668 | 36,625,000 | 9.37% | ||
| 3 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,733,828 | 28,764,000 | 7.36% | ||
| 4 | WELLINGTON MANAGEMENT GROUP LLP | 1,620,046 | 26,877,000 | 6.87% | ||
| 5 | VANGUARD GROUP INC | 1,278,464 | 21,209,000 | 5.42% | ||
| 6 | JANUS HENDERSON INVESTORS US LLC | 1,249,686 | 20,732,000 | 5.30% | ||
| 7 | PFM Health Sciences, LP | 1,028,867 | 17,069,000 | 4.37% | ||
| 8 | SECTORAL ASSET MANAGEMENT INC | 987,224 | 16,378,000 | 4.19% | ||
| 9 | Avoro Capital Advisors LLC | 963,646 | 15,987,000 | 4.09% | ||
| 10 | FORESITE CAPITAL MANAGEMENT III, LLC | 690,269 | 11,452,000 | 2.93% | ||
| 11 | CASDIN CAPITAL, LLC | 430,000 | 7,134,000 | 1.82% | ||
| 12 | BlackRock Fund Advisors | 332,665 | 5,519,000 | 1.41% | ||
| 13 | BLACKROCK ADVISORS LLC | 323,090 | 5,360,000 | 1.37% | ||
| 14 | Iguana Healthcare Management, LLC | 300,000 | 4,977,000 | 1.27% | ||
| 15 | SABBY MANAGEMENT, LLC | 254,029 | 4,214,000 | 1.08% | ||
| 16 | JENNISON ASSOCIATES LLC | 237,172 | 3,935,000 | 1.01% | ||
| 17 | STATE STREET CORP | 179,026 | 2,971,000 | 0.76% | ||
| 18 | JPMORGAN CHASE & CO | 176,855 | 2,935,000 | 0.75% | ||
| 19 | BlackRock Group LTD | 175,072 | 2,904,000 | 0.74% | ||
| 20 | VHCP MANAGEMENT II, LLC | 170,312 | 2,825,000 | 0.72% | ||
| 21 | EVENTIDE ASSET MANAGEMENT, LLC | 165,000 | 2,737,000 | 0.70% | ||
| 22 | NORTHERN TRUST CORP | 155,565 | 2,581,000 | 0.66% | ||
| 23 | Spark Investment Management LLC | 154,000 | 2,554,000 | 0.65% | ||
| 24 | Opaleye Management Inc. | 152,000 | 2,522,000 | 0.64% | ||
| 25 | DRIEHAUS CAPITAL MANAGEMENT LLC | 144,912 | 2,404,000 | 0.61% | ||
| 26 | BlackRock Institutional Trust Company, N.A. | 142,197 | 2,359,000 | 0.60% | ||
| 27 | Asset Management One Co., Ltd. | 143,191 | 2,305,000 | 0.59% | ||
| 28 | MILLENNIUM MANAGEMENT LLC | 134,115 | 2,225,000 | 0.57% | ||
| 29 | UBS Group AG | 128,813 | 2,137,000 | 0.55% | ||
| 30 | Artal Group S.A. | 125,000 | 2,074,000 | 0.53% | ||
| 31 | Tekla Capital Management LLC | 125,000 | 2,074,000 | 0.53% | ||
| 32 | Laurion Capital Management LP | 105,000 | 1,742,000 | 0.45% | ||
| 33 | FNY Managed Accounts LLC | 100,700 | 1,670,613 | 0.43% | ||
| 34 | Rock Springs Capital Management LP | 98,000 | 1,626,000 | 0.42% | ||
| 35 | RTW INVESTMENTS, LP | 97,138 | 1,612,000 | 0.41% | ||
| 36 | HIGHLAND CAPITAL MANAGEMENT LP | 82,200 | 1,363,000 | 0.35% | ||
| 37 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 80,900 | 1,342,000 | 0.34% | Put | |
| 38 | SCHONFELD STRATEGIC ADVISORS LLC | 77,912 | 1,293,000 | 0.33% | ||
| 39 | VHCP Management, LLC | 72,990 | 1,211,000 | 0.31% | ||
| 40 | MORGAN STANLEY | 72,872 | 1,209,000 | 0.31% | ||
| 41 | BlackRock Investment Management, LLC | 70,327 | 1,167,000 | 0.30% | ||
| 42 | GOLDMAN SACHS GROUP INC | 68,529 | 1,137,000 | 0.29% | ||
| 43 | LMR Partners LLP | 63,531 | 1,054,000 | 0.27% | ||
| 44 | A.R.T. Advisors, LLC | 63,180 | 1,048,000 | 0.27% | ||
| 45 | GEODE CAPITAL MANAGEMENT, LLC | 62,715 | 1,040,000 | 0.27% | ||
| 46 | J. Goldman & Co LP | 62,100 | 1,030,000 | 0.26% | ||
| 47 | NORGES BANK | 60,000 | 995,000 | 0.25% | ||
| 48 | THRIVENT FINANCIAL FOR LUTHERANS | 51,470 | 854,000 | 0.22% | ||
| 49 | OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 50,000 | 830,000 | 0.21% | ||
| 50 | MILLENNIUM MANAGEMENT LLC | 50,000 | 830,000 | 0.21% | Call |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
