| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Third Rock Ventures, LLC | 14,760,900 | 622,320,000 | 55.62% | ||
| 2 | FMR LLC | 4,414,433 | 186,112,000 | 16.63% | ||
| 3 | PERCEPTIVE ADVISORS LLC | 921,800 | 38,863,000 | 3.47% | ||
| 4 | DEERFIELD MANAGEMENT COMPANY, L.P. | 890,620 | 37,549,000 | 3.36% | ||
| 5 | PFM Health Sciences, LP | 758,816 | 31,992,000 | 2.86% | ||
| 6 | WELLINGTON MANAGEMENT GROUP LLP | 685,714 | 28,339,000 | 2.53% | ||
| 7 | RA CAPITAL MANAGEMENT, L.P. | 457,142 | 19,273,000 | 1.72% | ||
| 8 | JENNISON ASSOCIATES LLC | 369,531 | 15,579,000 | 1.39% | ||
| 9 | SABBY MANAGEMENT, LLC | 342,857 | 14,455,000 | 1.29% | ||
| 10 | RS INVESTMENT MANAGEMENT CO LLC | 317,800 | 13,398,000 | 1.20% | ||
| 11 | Redmile Group, LLC | 262,892 | 11,084,000 | 0.99% | ||
| 12 | DRIEHAUS CAPITAL MANAGEMENT LLC | 243,399 | 10,262,000 | 0.92% | ||
| 13 | JPMORGAN CHASE & CO | 213,575 | 9,005,000 | 0.80% | ||
| 14 | BAKER BROS. ADVISORS LP | 200,000 | 8,432,000 | 0.75% | ||
| 15 | BLACKROCK ADVISORS LLC | 192,691 | 8,124,000 | 0.73% | ||
| 16 | BlackRock Fund Advisors | 164,767 | 6,947,000 | 0.62% | ||
| 17 | LORD, ABBETT & CO. LLC | 161,577 | 6,812,000 | 0.61% | ||
| 18 | BlackRock Group LTD | 116,400 | 4,907,000 | 0.44% | ||
| 19 | RTW INVESTMENTS, LP | 92,399 | 3,896,000 | 0.35% | ||
| 20 | MORGAN STANLEY | 86,057 | 3,628,000 | 0.32% | ||
| 21 | STATE STREET CORP | 75,233 | 3,170,000 | 0.28% | ||
| 22 | Asset Management One Co., Ltd. | 79,148 | 3,158,000 | 0.28% | ||
| 23 | MILLENNIUM MANAGEMENT LLC | 72,168 | 3,043,000 | 0.27% | ||
| 24 | Iguana Healthcare Management, LLC | 65,000 | 2,740,000 | 0.24% | ||
| 25 | BlackRock Institutional Trust Company, N.A. | 63,147 | 2,662,000 | 0.24% | ||
| 26 | Rock Springs Capital Management LP | 60,000 | 2,530,000 | 0.23% | ||
| 27 | VANGUARD GROUP INC | 48,719 | 2,054,000 | 0.18% | ||
| 28 | PUTNAM INVESTMENTS LLC | 43,162 | 1,820,000 | 0.16% | ||
| 29 | LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 42,200 | 1,779,000 | 0.16% | ||
| 30 | GEODE CAPITAL MANAGEMENT, LLC | 41,351 | 1,743,000 | 0.16% | ||
| 31 | BlackRock Investment Management, LLC | 35,095 | 1,480,000 | 0.13% | ||
| 32 | BlackRock Finance, Inc. | 31,700 | 1,336,000 | 0.12% | ||
| 33 | SOROS FUND MANAGEMENT LLC | 21,000 | 885,000 | 0.08% | ||
| 34 | TIAA CREF INVESTMENT MANAGEMENT LLC | 20,605 | 869,000 | 0.08% | ||
| 35 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 20,200 | 852,000 | 0.08% | ||
| 36 | Partner Investment Management, L.P. | 17,892 | 754,000 | 0.07% | ||
| 37 | FRED ALGER MANAGEMENT, LLC | 17,850 | 753,000 | 0.07% | ||
| 38 | ALLIANCEBERNSTEIN L.P. | 17,516 | 738,000 | 0.07% | ||
| 39 | Bank of New York Mellon Corp | 16,185 | 683,000 | 0.06% | ||
| 40 | NORTHERN TRUST CORP | 15,996 | 674,000 | 0.06% | ||
| 41 | EVENTIDE ASSET MANAGEMENT, LLC | 15,479 | 653,000 | 0.06% | ||
| 42 | CREDIT SUISSE AG/ | 14,971 | 631,000 | 0.06% | ||
| 43 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 12,600 | 531,000 | 0.05% | ||
| 44 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 10,912 | 460,000 | 0.04% | ||
| 45 | TUDOR INVESTMENT CORP ET AL | 8,200 | 346,000 | 0.03% | ||
| 46 | TEACHERS ADVISORS, LLC | 6,986 | 295,000 | 0.03% | ||
| 47 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 6,040 | 255,000 | 0.02% | ||
| 48 | GOLDMAN SACHS GROUP INC | 5,999 | 253,000 | 0.02% | ||
| 49 | BANK OF MONTREAL /CAN/ | 4,000 | 169,000 | 0.02% | ||
| 50 | Tower Research Capital LLC (TRC) | 2,330 | 99,000 | 0.01% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
