| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 5,597,467 | 80,883,000 | 21.95% | ||
| 2 | PERCEPTIVE ADVISORS LLC | 3,128,978 | 45,213,000 | 12.27% | ||
| 3 | WELLINGTON MANAGEMENT GROUP LLP | 2,095,129 | 30,275,000 | 8.21% | ||
| 4 | VANGUARD GROUP INC | 1,809,614 | 26,148,000 | 7.09% | ||
| 5 | SECTORAL ASSET MANAGEMENT INC | 1,125,801 | 16,268,000 | 4.41% | ||
| 6 | JANUS HENDERSON INVESTORS US LLC | 1,073,338 | 15,512,000 | 4.21% | ||
| 7 | BlackRock Fund Advisors | 1,010,270 | 14,598,000 | 3.96% | ||
| 8 | GREAT POINT PARTNERS LLC | 1,000,000 | 14,450,000 | 3.92% | ||
| 9 | Avoro Capital Advisors LLC | 995,838 | 14,390,000 | 3.90% | ||
| 10 | MARSHALL WACE, LLP | 724,024 | 10,462,000 | 2.84% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 536,582 | 7,754,000 | 2.10% | ||
| 12 | Tekla Capital Management LLC | 381,300 | 5,510,000 | 1.50% | ||
| 13 | BLACKROCK ADVISORS LLC | 352,185 | 5,089,000 | 1.38% | ||
| 14 | PRICE T ROWE ASSOCIATES INC /MD/ | 342,573 | 4,950,000 | 1.34% | ||
| 15 | Redmile Group, LLC | 316,400 | 4,572,000 | 1.24% | ||
| 16 | CASDIN CAPITAL, LLC | 304,000 | 4,393,000 | 1.19% | ||
| 17 | PRUDENTIAL FINANCIAL INC | 298,176 | 4,308,000 | 1.17% | ||
| 18 | STATE STREET CORP | 289,984 | 4,174,000 | 1.13% | ||
| 19 | Artal Group S.A. | 246,054 | 3,555,000 | 0.96% | ||
| 20 | NORTHERN TRUST CORP | 228,608 | 3,303,000 | 0.90% | ||
| 21 | BlackRock Group LTD | 186,405 | 2,694,000 | 0.73% | ||
| 22 | Century Capital Management, LLC | 179,601 | 2,595,000 | 0.70% | ||
| 23 | JPMORGAN CHASE & CO | 175,825 | 2,540,000 | 0.69% | ||
| 24 | Iguana Healthcare Management, LLC | 175,000 | 2,529,000 | 0.69% | ||
| 25 | DEERFIELD MANAGEMENT COMPANY, L.P. | 171,428 | 2,477,000 | 0.67% | ||
| 26 | EVENTIDE ASSET MANAGEMENT, LLC | 165,000 | 2,384,000 | 0.65% | ||
| 27 | GEODE CAPITAL MANAGEMENT, LLC | 153,169 | 2,213,000 | 0.60% | ||
| 28 | OXFORD ASSET MANAGEMENT LLP | 140,845 | 2,035,000 | 0.55% | ||
| 29 | MORGAN STANLEY | 139,549 | 2,016,000 | 0.55% | ||
| 30 | SPHERA FUNDS MANAGEMENT LTD. | 125,000 | 1,806,000 | 0.49% | ||
| 31 | Rock Springs Capital Management LP | 96,500 | 1,394,000 | 0.38% | ||
| 32 | WELLS FARGO & COMPANY/MN | 96,205 | 1,391,000 | 0.38% | ||
| 33 | HARBOURVEST PARTNERS LLC | 93,960 | 1,358,000 | 0.37% | ||
| 34 | CREDIT SUISSE AG/ | 93,576 | 1,352,000 | 0.37% | ||
| 35 | TIAA CREF INVESTMENT MANAGEMENT LLC | 92,934 | 1,343,000 | 0.36% | ||
| 36 | BlackRock Investment Management, LLC | 86,180 | 1,245,000 | 0.34% | ||
| 37 | Bank of New York Mellon Corp | 77,796 | 1,124,000 | 0.30% | ||
| 38 | Candriam S.C.A. | 77,000 | 1,113,000 | 0.30% | ||
| 39 | MOORE CAPITAL MANAGEMENT, LP | 75,000 | 1,084,000 | 0.29% | ||
| 40 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 66,422 | 960,000 | 0.26% | ||
| 41 | FORESITE CAPITAL MANAGEMENT III, LLC | 63,627 | 919,000 | 0.25% | ||
| 42 | NEXTHERA CAPITAL LP | 60,000 | 867,000 | 0.24% | ||
| 43 | Fernwood Investment Management, LLC | 57,484 | 831,000 | 0.23% | ||
| 44 | FIRST MIDWEST BANK TRUST DIVISION | 56,125 | 811,000 | 0.22% | ||
| 45 | BlackRock Finance, Inc. | 54,839 | 792,000 | 0.21% | ||
| 46 | THRIVENT FINANCIAL FOR LUTHERANS | 51,470 | 744,000 | 0.20% | ||
| 47 | ABERDEEN ASSET MANAGEMENT PLC/UK | 46,293 | 669,000 | 0.18% | ||
| 48 | GOLDMAN SACHS GROUP INC | 39,650 | 573,000 | 0.16% | ||
| 49 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 36,300 | 525,000 | 0.14% | Put | |
| 50 | DEUTSCHE BANK AG\ | 36,551 | 525,000 | 0.14% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
