| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 5,592,811 | 128,914,000 | 26.50% | ||
| 2 | PERCEPTIVE ADVISORS LLC | 2,334,168 | 53,802,000 | 11.06% | ||
| 3 | WELLINGTON MANAGEMENT GROUP LLP | 2,165,511 | 49,915,000 | 10.26% | ||
| 4 | VANGUARD GROUP INC | 1,474,200 | 33,981,000 | 6.98% | ||
| 5 | JANUS HENDERSON INVESTORS US LLC | 1,216,905 | 28,050,000 | 5.77% | ||
| 6 | SECTORAL ASSET MANAGEMENT INC | 1,031,449 | 23,775,000 | 4.89% | ||
| 7 | Avoro Capital Advisors LLC | 869,263 | 20,037,000 | 4.12% | ||
| 8 | FORESITE CAPITAL MANAGEMENT III, LLC | 455,590 | 10,501,000 | 2.16% | ||
| 9 | BlackRock Fund Advisors | 426,591 | 9,833,000 | 2.02% | ||
| 10 | DRIEHAUS CAPITAL MANAGEMENT LLC | 374,108 | 8,623,000 | 1.77% | ||
| 11 | BLACKROCK ADVISORS LLC | 338,196 | 7,795,000 | 1.60% | ||
| 12 | Iguana Healthcare Management, LLC | 325,000 | 7,491,000 | 1.54% | ||
| 13 | BlackRock Institutional Trust Company, N.A. | 314,491 | 7,249,000 | 1.49% | ||
| 14 | STATE STREET CORP | 285,960 | 6,593,000 | 1.36% | ||
| 15 | CASDIN CAPITAL, LLC | 240,000 | 5,532,000 | 1.14% | ||
| 16 | NORTHERN TRUST CORP | 220,148 | 5,075,000 | 1.04% | ||
| 17 | Opaleye Management Inc. | 200,000 | 4,610,000 | 0.95% | ||
| 18 | JPMORGAN CHASE & CO | 185,305 | 4,272,000 | 0.88% | ||
| 19 | BlackRock Group LTD | 174,002 | 4,010,000 | 0.82% | ||
| 20 | DEERFIELD MANAGEMENT COMPANY, L.P. | 171,428 | 3,951,000 | 0.81% | ||
| 21 | EVENTIDE ASSET MANAGEMENT, LLC | 165,000 | 3,803,000 | 0.78% | ||
| 22 | GEODE CAPITAL MANAGEMENT, LLC | 134,467 | 3,099,000 | 0.64% | ||
| 23 | PRUDENTIAL FINANCIAL INC | 130,525 | 3,009,000 | 0.62% | ||
| 24 | Tekla Capital Management LLC | 125,000 | 2,881,000 | 0.59% | ||
| 25 | Asset Management One Co., Ltd. | 130,374 | 2,667,000 | 0.55% | ||
| 26 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 114,700 | 2,644,000 | 0.54% | Call | |
| 27 | RENAISSANCE TECHNOLOGIES LLC | 101,200 | 2,333,000 | 0.48% | ||
| 28 | Artal Group S.A. | 100,000 | 2,305,000 | 0.47% | ||
| 29 | Rock Springs Capital Management LP | 98,000 | 2,259,000 | 0.46% | ||
| 30 | RTW INVESTMENTS, LP | 95,714 | 2,206,000 | 0.45% | ||
| 31 | Century Capital Management, LLC | 95,041 | 2,191,000 | 0.45% | ||
| 32 | BlackRock Investment Management, LLC | 84,648 | 1,951,000 | 0.40% | ||
| 33 | D. E. Shaw & Co., Inc. | 82,374 | 1,899,000 | 0.39% | ||
| 34 | DEUTSCHE BANK AG\ | 76,317 | 1,757,000 | 0.36% | ||
| 35 | Bank of New York Mellon Corp | 71,275 | 1,642,000 | 0.34% | ||
| 36 | FIRST MIDWEST BANK TRUST DIVISION | 68,825 | 1,586,000 | 0.33% | ||
| 37 | Spark Investment Management LLC | 64,400 | 1,484,000 | 0.31% | ||
| 38 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 62,726 | 1,446,000 | 0.30% | ||
| 39 | TIAA CREF INVESTMENT MANAGEMENT LLC | 62,651 | 1,444,000 | 0.30% | ||
| 40 | Candriam S.C.A. | 60,000 | 1,383,000 | 0.28% | ||
| 41 | THRIVENT FINANCIAL FOR LUTHERANS | 51,470 | 1,187,000 | 0.24% | ||
| 42 | DIALECTIC CAPITAL MANAGEMENT, LP | 51,000 | 1,176,000 | 0.24% | ||
| 43 | BlackRock Finance, Inc. | 49,739 | 1,147,000 | 0.24% | ||
| 44 | NORGES BANK | 48,600 | 1,070,000 | 0.22% | ||
| 45 | Fernwood Investment Management, LLC | 40,000 | 922,000 | 0.19% | ||
| 46 | OXFORD ASSET MANAGEMENT LLP | 38,645 | 891,000 | 0.18% | ||
| 47 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 34,990 | 807,000 | 0.17% | ||
| 48 | MARCUS CAPITAL, LLC | 30,100 | 694,000 | 0.14% | ||
| 49 | ALLIANCEBERNSTEIN L.P. | 28,500 | 657,000 | 0.14% | ||
| 50 | CITADEL ADVISORS LLC | 28,127 | 648,000 | 0.13% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
