| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 5,759,471 | 212,236,000 | 20.99% | ||
| 2 | PERCEPTIVE ADVISORS LLC | 3,858,978 | 142,203,000 | 14.07% | ||
| 3 | BlackRock Finance, Inc. | 2,618,847 | 96,503,000 | 9.55% | ||
| 4 | VANGUARD GROUP INC | 2,535,980 | 93,451,000 | 9.24% | ||
| 5 | WELLINGTON MANAGEMENT GROUP LLP | 2,321,123 | 85,534,000 | 8.46% | ||
| 6 | ORBIMED ADVISORS LLC | 1,084,500 | 39,964,000 | 3.95% | ||
| 7 | Redmile Group, LLC | 934,343 | 34,431,000 | 3.41% | ||
| 8 | CITADEL ADVISORS LLC | 837,252 | 30,852,000 | 3.05% | ||
| 9 | JANUS HENDERSON INVESTORS US LLC | 806,283 | 29,710,000 | 2.94% | ||
| 10 | STATE STREET CORP | 672,728 | 24,788,000 | 2.45% | ||
| 11 | LORD, ABBETT & CO. LLC | 539,944 | 19,897,000 | 1.97% | ||
| 12 | SECTORAL ASSET MANAGEMENT INC | 345,582 | 12,735,000 | 1.26% | ||
| 13 | MORGAN STANLEY | 334,872 | 12,340,000 | 1.22% | ||
| 14 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 324,200 | 11,947,000 | 1.18% | Call | |
| 15 | GREAT POINT PARTNERS LLC | 300,000 | 11,055,000 | 1.09% | ||
| 16 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 296,900 | 10,941,000 | 1.08% | Put | |
| 17 | NORTHERN TRUST CORP | 256,114 | 9,439,000 | 0.93% | ||
| 18 | GEODE CAPITAL MANAGEMENT, LLC | 244,667 | 9,015,000 | 0.89% | ||
| 19 | JPMORGAN CHASE & CO | 224,207 | 8,262,000 | 0.82% | ||
| 20 | Artal Group S.A. | 175,000 | 6,449,000 | 0.64% | ||
| 21 | Tekla Capital Management LLC | 172,500 | 6,357,000 | 0.63% | ||
| 22 | EVENTIDE ASSET MANAGEMENT, LLC | 165,000 | 6,080,000 | 0.60% | ||
| 23 | TEACHERS ADVISORS, LLC | 156,195 | 5,756,000 | 0.57% | ||
| 24 | DRIEHAUS CAPITAL MANAGEMENT LLC | 145,582 | 5,365,000 | 0.53% | ||
| 25 | Bank of New York Mellon Corp | 139,389 | 5,137,000 | 0.51% | ||
| 26 | TIAA CREF INVESTMENT MANAGEMENT LLC | 130,606 | 4,813,000 | 0.48% | ||
| 27 | WELLS FARGO & COMPANY/MN | 120,568 | 4,443,000 | 0.44% | ||
| 28 | Century Capital Management, LLC | 119,947 | 4,420,000 | 0.44% | ||
| 29 | OXFORD ASSET MANAGEMENT LLP | 118,495 | 4,367,000 | 0.43% | ||
| 30 | York Capital Management Global Advisors, LLC | 115,000 | 4,238,000 | 0.42% | ||
| 31 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 110,805 | 4,084,000 | 0.40% | ||
| 32 | GOLDMAN SACHS GROUP INC | 101,881 | 3,754,000 | 0.37% | ||
| 33 | BARCLAYS PLC | 97,380 | 3,589,000 | 0.36% | ||
| 34 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 95,230 | 3,509,000 | 0.35% | ||
| 35 | CREDIT SUISSE AG/ | 91,115 | 3,358,000 | 0.33% | ||
| 36 | DEUTSCHE BANK AG\ | 75,912 | 2,794,000 | 0.28% | ||
| 37 | PRUDENTIAL FINANCIAL INC | 75,246 | 2,773,000 | 0.27% | ||
| 38 | INTERNATIONAL BIOTECHNOLOGY TRUST PLC | 58,000 | 2,134,000 | 0.21% | ||
| 39 | NATIXIS | 54,815 | 2,020,000 | 0.20% | ||
| 40 | GROUP ONE TRADING LLC | 51,035 | 1,881,000 | 0.19% | ||
| 41 | ING GROEP NV | 43,920 | 1,618,000 | 0.16% | ||
| 42 | MILLENNIUM MANAGEMENT LLC | 43,404 | 1,599,000 | 0.16% | ||
| 43 | AMERIPRISE FINANCIAL INC | 40,972 | 1,510,000 | 0.15% | ||
| 44 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 39,490 | 1,455,000 | 0.14% | ||
| 45 | BARCLAYS PLC | 38,300 | 1,411,000 | 0.14% | Call | |
| 46 | ALPS ADVISORS INC | 36,492 | 1,345,000 | 0.13% | ||
| 47 | CITADEL ADVISORS LLC | 33,500 | 1,234,000 | 0.12% | Call | |
| 48 | CITADEL ADVISORS LLC | 33,200 | 1,223,000 | 0.12% | Put | |
| 49 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 30,659 | 1,130,000 | 0.11% | ||
| 50 | THRIVENT FINANCIAL FOR LUTHERANS | 30,400 | 1,120,000 | 0.11% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
