| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Capital World Investors | 3,002,044 | 85,648,000 | 7.09% | ||
| 2 | FMR LLC | 2,665,700 | 76,052,000 | 6.29% | ||
| 3 | LORD, ABBETT & CO. LLC | 2,522,165 | 71,957,000 | 5.95% | ||
| 4 | Visium Asset Management, LP | 2,448,867 | 69,867,000 | 5.78% | ||
| 5 | Point72 Asset Management, L.P. | 2,319,887 | 66,186,000 | 5.48% | ||
| 6 | Aisling Capital LLC | 2,103,528 | 60,014,000 | 4.97% | ||
| 7 | EAGLE ASSET MANAGEMENT INC | 1,600,825 | 45,671,000 | 3.78% | ||
| 8 | VANGUARD GROUP INC | 1,240,999 | 35,406,000 | 2.93% | ||
| 9 | RS INVESTMENT MANAGEMENT CO LLC | 1,181,996 | 33,722,000 | 2.79% | ||
| 10 | MILLENNIUM MANAGEMENT LLC | 1,092,691 | 31,174,000 | 2.58% | ||
| 11 | RIVERBRIDGE PARTNERS LLC | 1,006,869 | 28,726,000 | 2.38% | ||
| 12 | NEXT CENTURY GROWTH INVESTORS LLC | 929,346 | 26,514,000 | 2.19% | ||
| 13 | PointState Capital LP | 915,100 | 26,108,000 | 2.16% | ||
| 14 | BlackRock Fund Advisors | 894,782 | 25,528,000 | 2.11% | ||
| 15 | BlackRock Institutional Trust Company, N.A. | 838,896 | 23,934,000 | 1.98% | ||
| 16 | Granahan Investment Management, LLC | 834,383 | 23,805,000 | 1.97% | ||
| 17 | Redmile Group, LLC | 709,426 | 20,240,000 | 1.67% | ||
| 18 | CITADEL ADVISORS LLC | 666,308 | 19,010,000 | 1.57% | ||
| 19 | STATE STREET CORP | 605,551 | 17,283,000 | 1.43% | ||
| 20 | Palo Alto Investors LP | 573,636 | 16,366,000 | 1.35% | ||
| 21 | FULLER & THALER ASSET MANAGEMENT, INC. | 548,697 | 15,654,000 | 1.30% | ||
| 22 | NORTHERN TRUST CORP | 537,764 | 15,343,000 | 1.27% | ||
| 23 | DEUTSCHE BANK AG\ | 536,061 | 15,292,000 | 1.27% | ||
| 24 | PFM Health Sciences, LP | 513,884 | 14,661,000 | 1.21% | ||
| 25 | COLUMBIA PARTNERS L.L.C. INVESTMENT MANAGEMENT | 490,165 | 13,984,000 | 1.16% | ||
| 26 | BLAIR WILLIAM & CO/IL | 475,481 | 13,565,000 | 1.12% | ||
| 27 | Polar Capital LLP | 414,747 | 11,833,000 | 0.98% | ||
| 28 | DRILL CRAIG A | 409,844 | 11,693,000 | 0.97% | ||
| 29 | WELLS FARGO & COMPANY/MN | 404,376 | 11,537,000 | 0.95% | ||
| 30 | TWO SIGMA INVESTMENTS, LP | 343,229 | 9,792,000 | 0.81% | ||
| 31 | Provident Investment Management, Inc. | 335,650 | 9,576,000 | 0.79% | ||
| 32 | AXA S.A. | 330,000 | 9,415,000 | 0.78% | ||
| 33 | Cupps Capital Management, LLC | 297,032 | 8,474,000 | 0.70% | ||
| 34 | HighTower Advisors, LLC | 289,917 | 8,274,000 | 0.68% | ||
| 35 | WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 280,756 | 8,010,000 | 0.66% | ||
| 36 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 277,780 | 7,925,000 | 0.66% | ||
| 37 | Ghost Tree Capital, LLC | 275,000 | 7,846,000 | 0.65% | ||
| 38 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 268,562 | 7,662,000 | 0.63% | ||
| 39 | Nichols Asset Management LLC | 251,578 | 7,178,000 | 0.59% | ||
| 40 | Pier Capital, LLC | 248,228 | 7,082,000 | 0.59% | ||
| 41 | QS Investors, LLC | 247,889 | 7,072,000 | 0.59% | ||
| 42 | PRICE T ROWE ASSOCIATES INC /MD/ | 246,831 | 7,042,000 | 0.58% | ||
| 43 | Bank of New York Mellon Corp | 232,398 | 6,631,000 | 0.55% | ||
| 44 | GEODE CAPITAL MANAGEMENT, LLC | 212,579 | 6,064,000 | 0.50% | ||
| 45 | RUSSELL FRANK CO/ | 211,197 | 6,044,000 | 0.50% | ||
| 46 | MORGAN STANLEY | 200,476 | 5,720,000 | 0.47% | ||
| 47 | AMERIPRISE FINANCIAL INC | 186,676 | 5,326,000 | 0.44% | ||
| 48 | Numeric Investors LLC | 171,380 | 4,889,000 | 0.40% | ||
| 49 | COLUMBUS CIRCLE INVESTORS | 169,895 | 4,847,000 | 0.40% | ||
| 50 | MIG Capital, LLC | 165,466 | 4,721,000 | 0.39% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
