| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 5,477,727 | 94,600,000 | 28.53% | ||
| 2 | BVF INC/IL | 1,804,675 | 31,167,000 | 9.40% | ||
| 3 | PERCEPTIVE ADVISORS LLC | 1,530,659 | 26,434,000 | 7.97% | ||
| 4 | BlackRock Finance, Inc. | 1,011,984 | 17,476,000 | 5.27% | ||
| 5 | DEERFIELD MANAGEMENT COMPANY, L.P. | 943,433 | 16,293,000 | 4.91% | ||
| 6 | VANGUARD GROUP INC | 823,531 | 14,223,000 | 4.29% | ||
| 7 | EcoR1 Capital, LLC | 794,969 | 13,729,000 | 4.14% | ||
| 8 | Redmile Group, LLC | 681,892 | 11,776,000 | 3.55% | ||
| 9 | Tekla Capital Management LLC | 530,092 | 9,155,000 | 2.76% | ||
| 10 | Opaleye Management Inc. | 340,000 | 5,871,000 | 1.77% | ||
| 11 | FRANKLIN RESOURCES INC | 333,500 | 5,760,000 | 1.74% | ||
| 12 | DRIEHAUS CAPITAL MANAGEMENT LLC | 294,694 | 5,089,000 | 1.53% | ||
| 13 | VHCP MANAGEMENT II, LLC | 288,915 | 4,990,000 | 1.50% | ||
| 14 | STATE STREET CORP | 280,973 | 4,852,000 | 1.46% | ||
| 15 | RENAISSANCE TECHNOLOGIES LLC | 234,800 | 4,055,000 | 1.22% | ||
| 16 | NORTHERN TRUST CORP | 231,984 | 4,006,000 | 1.21% | ||
| 17 | Cormorant Asset Management, LP | 230,000 | 3,972,000 | 1.20% | ||
| 18 | GEODE CAPITAL MANAGEMENT, LLC | 208,710 | 3,604,000 | 1.09% | ||
| 19 | Candriam S.C.A. | 195,000 | 3,368,000 | 1.02% | ||
| 20 | Private Advisor Group, LLC | 197,177 | 3,356,000 | 1.01% | ||
| 21 | JPMORGAN CHASE & CO | 185,778 | 3,208,000 | 0.97% | ||
| 22 | CASDIN CAPITAL, LLC | 177,500 | 3,065,000 | 0.92% | ||
| 23 | MILLENNIUM MANAGEMENT LLC | 167,690 | 2,896,000 | 0.87% | ||
| 24 | EVENTIDE ASSET MANAGEMENT, LLC | 150,000 | 2,591,000 | 0.78% | ||
| 25 | SPHERA FUNDS MANAGEMENT LTD. | 150,000 | 2,591,000 | 0.78% | ||
| 26 | PRICE T ROWE ASSOCIATES INC /MD/ | 148,305 | 2,561,000 | 0.77% | ||
| 27 | Montecito Bank & Trust | 146,544 | 2,531,000 | 0.76% | ||
| 28 | Spark Investment Management LLC | 101,700 | 1,756,000 | 0.53% | ||
| 29 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 100,091 | 1,729,000 | 0.52% | ||
| 30 | Bank of New York Mellon Corp | 86,458 | 1,493,000 | 0.45% | ||
| 31 | BANK OF AMERICA CORP /DE/ | 78,223 | 1,351,000 | 0.41% | ||
| 32 | Vident Investment Advisory, LLC | 75,924 | 1,311,000 | 0.40% | ||
| 33 | Iguana Healthcare Management, LLC | 75,000 | 1,295,000 | 0.39% | ||
| 34 | PUTNAM INVESTMENTS LLC | 74,819 | 1,292,000 | 0.39% | ||
| 35 | LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 70,943 | 1,225,000 | 0.37% | ||
| 36 | REGENTS OF THE UNIVERSITY OF CALIFORNIA | 70,584 | 1,219,000 | 0.37% | ||
| 37 | Trexquant Investment LP | 60,979 | 1,053,000 | 0.32% | ||
| 38 | TIAA CREF INVESTMENT MANAGEMENT LLC | 59,761 | 1,032,000 | 0.31% | ||
| 39 | MORGAN STANLEY | 53,084 | 916,000 | 0.28% | ||
| 40 | MONASHEE INVESTMENT MANAGEMENT LLC | 46,224 | 798,000 | 0.24% | PRN | |
| 41 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 40,230 | 695,000 | 0.21% | ||
| 42 | CRAWFORD LAKE CAPITAL MANAGEMENT, LLC | 35,000 | 604,000 | 0.18% | ||
| 43 | TEACHERS ADVISORS, LLC | 34,961 | 604,000 | 0.18% | ||
| 44 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 34,627 | 598,000 | 0.18% | ||
| 45 | ALLIANCEBERNSTEIN L.P. | 34,600 | 598,000 | 0.18% | ||
| 46 | OXFORD ASSET MANAGEMENT LLP | 31,665 | 547,000 | 0.16% | ||
| 47 | Invesco Ltd. | 30,925 | 534,000 | 0.16% | ||
| 48 | PRUDENTIAL FINANCIAL INC | 28,070 | 485,000 | 0.15% | ||
| 49 | DEUTSCHE BANK AG\ | 27,968 | 482,000 | 0.15% | ||
| 50 | Swiss National Bank | 26,800 | 463,000 | 0.14% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
